Platelet-Rich Plasma

Foster, Timothy E.; Puskas, Brian L.; Mandelbaum, Bert R.; Gerhardt, Michael B.; Rodeo, Scott A.

doi:10.1177/0363546509349921

Cited by 1,085 publications

(448 citation statements)

References 80 publications

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“…Today, in the field of general surgery, its benefits have been shown in pathologies such as perianal fistulas, hidradenitissuppurativa, liver injury, anastomotic leak and acute abdomen 7,12 . The conviction in literature with respect to PRP, in general, is of the same leaning.…”

Section: Discussionmentioning

confidence: 99%

“…Autologous Platelet-rich plasma (PRP), recently, has become popular as a treatment modality in the areas of orthopedic and trauma surgery, spinal surgery, plastic-reconstructive surgery, oral and maxillofacial-dental surgery, ophthalmological surgery, heart by-pass surgery and burns [7][8][9] . It contains the growth factors; platelet-derived growth factor (PDGF), epidermal growth factor,fibroblast growth factor(FGF), transforming growth factor-β(TGF-β), insulin-like growth factor (IGF-I, IGF-II), endothelial cell growth factor and vascular endothelial growth factor (VEGF).…”

Section: Introductionmentioning

confidence: 99%

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Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis

et al. 2016

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PURPOSE:To evaluate the effects of platelet rich plasma (PRP) on the healing of fascia wherein peritonitis has been created. METHODS:Twenty eight Wistar Albino rats were divided into four groups. Only a primary fascial repair following laparotomy was performed on Group 1, a primary fascial repair performed and PRP treatment applied following laparotomy on Group 2, and a fecal peritonitis created following laparotomy and a primary fascial repair carried out on Group 3. A fecal peritonitis was created following laparotomy and primary fascial repair and PRP treatment on the fascia was carried out on Group 4. RESULTS:TNF-α was found to be significantly lower in the control group (Group 1). It was detected at the highest level in the group in which fecal peritonitis was created and PRP applied (Group 4). TGF-β was determined as being significantly higher only in Group 4. Histopathologically, the differences between the groups in terms of cell infiltration and collagen deposition were not found to be significant. CONCLUSION:When platelet rich plasma was given histologically and biochemicaly as wound healing parameters cellular infiltration, collagen accumulation, and tissue hydroxyiproline levels were not increased but neovascularization, fibroblast activation and TNF Alfa levels were increased and PRP accelerated wound healing.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis

et al. 2016

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“…в публика-циях описано применение PRP в целях лечения переломов костей, трофических язв различной этиологии, а также в пластической хирургии и косметологии для омоложения кожи и лечения волос [1,8]. Впоследствии в мировой литерату-ре появились сообщения о ее использовании и в ортопедо-травматологической практике, причем сначала в спортивной травматологии [10][11][12][13].…”

Section: история и основные направления применения богатой тромбоцитаunclassified

“…Взаимосвязь путей гемоциркуляции в костной ткани проявляется не только в местных нутри-тивных процессах и поддержании общего мине-рального равновесия внутренней среды орга-низма, но и непосредственно в физиологической регенерации костной ткани [7,13,31].…”

Section: история и основные направления применения богатой тромбоцитаunclassified

“…Один из них -TGF-1, как доказано многими специалистами по клеточ-ным технологиям, и морфогенетические белки кости модулируют клеточную пролиферацию и дифференцировку малодифференцированных клеток в остеобласты, увеличивают синтез вне-клеточного матрикса кости и ингибируют его деградацию [2, 13,28,42,43]. К основным типам костных морфогенетических белков, участвую-щих в регуляции сращения переломов, по дан-ным исследований, опубликованных зарубежны-ми авторами в 2012-2014 гг., относятся: BMP2 -оказывающий воздействие на образование хряща и кости и играющий основную роль в дифферен-цировке остеобластов, BMP3 -действующий на образование самой кости, BMP7 -служащий основой для дифференцировки остеобластов, и BMP8a -принимающий самое активное участие в развитии кости и хряща [24,44,45].…”

Section: история и основные направления применения богатой тромбоцитаunclassified

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The use of platelet rich plasma in diseases and injuries of the musculoskeletal system

Malygina¹,

Borovkova²,

Sakharova³

et al. 2017

Transplantologiâ (Mosk.)

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Intra-Articular Platelet-Rich Plasma Injection After Anterior Cruciate Ligament Reconstruction

Ye,

Chen,

Qiao

et al. 2024

JAMA Netw Open

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ImportancePlatelet-rich plasma (PRP) has been considered a promising treatment for musculoskeletal disorders. The effects of PRP on clinical outcomes of anterior cruciate ligament reconstruction (ACLR) are controversial.ObjectiveTo compare subjective outcomes and graft maturity in patients undergoing ACLR with and without postoperative intra-articular PRP injection.Design, Setting, and ParticipantsThis surgeon- and investigator-masked randomized clinical trial included patients treated at a national medical center in China who were aged 16 to 45 years and scheduled to undergo ACLR. Participants were enrolled between March 21, 2021, and August 18, 2022, and followed up for 12 months, with the last participant completing follow-up on August 28, 2023.InterventionsParticipants were randomized 1:1 to the PRP group (n = 60), which received 3 doses of postoperative intra-articular PRP injection at monthly intervals, or to the control group (n = 60), which did not receive postoperative PRP injection. Both groups had the same follow-up schedule.Main Outcomes and MeasuresThe primary outcome was the mean score for 4 subscales of the Knee Injury and Osteoarthritis Outcome Score (KOOS4) (range, 0-100, with higher scores indicating better knee function and fewer symptoms) at 12 months postoperatively. Secondary outcomes were patient-reported outcomes, graft maturity (on magnetic resonance imaging), and physical examinations at 3, 6, and 12 months.ResultsAmong the 120 randomized participants (mean [SD] age, 29.0 [8.0] years; 84 males [70%]), 114 (95%) were available for the primary outcome analysis. The mean KOOS4 scores at 12 months were 78.3 (SD, 12.0; 95% CI, 75.2-81.4) in the PRP group and 76.8 (SD, 11.9; 95% CI, 73.7-79.9) in the control group (adjusted mean between-group difference, 2.0; 95% CI, −2.3 to 6.3; P = .36). Secondary outcomes were not statistically significantly different between the 2 groups except for sports and recreation level and graft maturity at 6 months. Intervention-related adverse events included pain at the injection site and knee swelling after injection.Conclusions and RelevanceIn this randomized clinical trial among patients undergoing ACLR, the addition of postoperative intra-articular PRP injection did not result in superior improvement of knee symptoms and function at 12 months compared with no postoperative injection. Further studies are required to determine appropriate indications for PRP in musculoskeletal disorders.Trial RegistrationChinese Clinical Trial Registry Identifier: ChiCTR2000040262

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Platelet-Rich Plasma

Cited by 1,085 publications

References 80 publications

Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis

Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis

The use of platelet rich plasma in diseases and injuries of the musculoskeletal system

Intra-Articular Platelet-Rich Plasma Injection After Anterior Cruciate Ligament Reconstruction

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