Platelet-Rich Plasma Inhibits Mechanically Induced Injury in Chondrocytes

Xie, Xuetao; Ulici, Veronica; Alexander, Peter G.; Jiang, Yangzi; Zhang, Changqing; Tuan, Rocky S.

doi:10.1016/j.arthro.2015.01.007

Cited by 23 publications

(10 citation statements)

References 33 publications

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“…2,3 In vitro data have demonstrated that PRP has a protective and anabolic effect on chondrocytes and tenocytes. [4][5][6][7] PRP injections are used to treat osteoarthritis (OA) and tendinosis, although highquality studies supporting these indications are limited. [8][9][10][11][12][13][14] Cellular and GF contents of PRP are highly variable due to several processing and physiologic variables.…”

Section: Introductionmentioning

confidence: 99%

High Intensity Interval Exercise Increases Platelet and Transforming Growth Factor‐β Yield in Platelet‐Rich Plasma

Baria

Miller

Borchers

et al. 2020

PM&R

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Background: Platelet-rich plasma (PRP) is an emerging orthobiologic treatment for musculoskeletal conditions like osteoarthritis. Two studies have demonstrated the influence of longer duration exercise on PRP composition, but no study has ever explored the impact of high intensity interval exercise (HIIE) on PRP content. Objective: To quantify cellular and growth factor content changes in PRP after 4 minutes of HIIE. Design: Controlled laboratory pilot study. Setting: Academic sports medicine center. Participants: Ten healthy volunteers (5 male, 5 female). Intervention: Volunteers had PRP prepared from 15 mL of whole blood using a single spin, plasma-based system (autologous conditioned plasma [ACP]) immediately before and after 4 minutes of HIIE on a stationary exercise bike (Tabata protocol). Main Outcome Measure: The PRP was sent for complete blood counts and enzyme-linked immunosorbent assay (ELISA) to quantify transforming growth factor (TGF)-β, platelet-derived growth factor (PDGF), insulin-like growth factor (IGF)-1, and vascular endothelial growth factor (VEGF). Results: Mean platelet count in PRP increased from 367.4 AE 57.5 k/μL to 497.7 AE 93.3 k/μL after 4 minutes of HIIE (P < .001). TGFβ also increased from 8237.2 AE 7676.5 pg/mL to 21 535.7 AE 4062.6 pg/mL postexercise (P = .004). The other cellular components (leukocytes, red blood cells, and mean platelet volume) and growth factors (PDGF, IGF-1, and VEGF) were not significantly changed. Conclusions: A short 4-minute bout of HIIE significantly increased the total platelet count and TGF-β concentration in PRP.

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Section: Introductionmentioning

confidence: 99%

High Intensity Interval Exercise Increases Platelet and Transforming Growth Factor‐β Yield in Platelet‐Rich Plasma

Baria

Miller

Borchers

et al. 2020

PM&R

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“…The use of PRP under ultrasound guidance, in the treatment of degenerative processes (34) and arthritic knee and hip, is efficient in terms of reduction of pain and recovery of functionality (35,36,37,38,39). The platelet gel exerts anti-inflammatory action related to the chemotactic activity towards cells of inflammation and promotes a true tissue regeneration due to the activation of growth factors (40).…”

Section: When and Howmentioning

confidence: 99%

Anaesthetics, steroids and platelet-rich plasma (PRP) in ultrasound-guided musculoskeletal procedures

Barile

Marra

Mariani

et al. 2016

BJR

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This review aims to evaluate the role of anaesthetics, steroids and platelet-rich plasma (PRP) employed with ultrasound-guided injection in the management of musculoskeletal pathology of the extremities. Ultrasound-guided injection represents an interesting and minimally invasive solution for the treatment of tendon and joint inflammatory or degenerative diseases. The availability of a variety of new drugs such as hyaluronic acid and PRP provides expansion of the indications and therapeutic possibilities. The clinical results obtained in terms of pain reduction and functional recovery suggest that the use of infiltrative procedures can be a good therapeutic alternative in degenerative and inflammatory joint diseases.

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“…Так чи інакше, субстратом для хрящового відновлення виступають меншою мірою власне хондроцити, а більшою -мультипотентні мезенхімальні стовбурові клітини. Хоча відомо про виражений хондрогенний потенціал ще двох груп клітин (синовіоцитів та адипоцитів), у цьому випадку їхнє значення для репарації другорядне, оскільки для виявлення вказаного потенціалу необхідне чітке дотримання певних умов [1,10,12].…”

Section: вступunclassified

Regeneration of full-length layers cartilage in experimental under the impaction platelet rich plasma

Vernygorodskyi¹,

Fishchenko²,

Rybinskyi³

2018

ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS

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Platelet-Rich Plasma Inhibits Mechanically Induced Injury in Chondrocytes

Cited by 23 publications

References 33 publications

High Intensity Interval Exercise Increases Platelet and Transforming Growth Factor‐β Yield in Platelet‐Rich Plasma

High Intensity Interval Exercise Increases Platelet and Transforming Growth Factor‐β Yield in Platelet‐Rich Plasma

Anaesthetics, steroids and platelet-rich plasma (PRP) in ultrasound-guided musculoskeletal procedures

Regeneration of full-length layers cartilage in experimental under the impaction platelet rich plasma

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