Platelet rich plasma injection versus topical erythromycin 2% in treatment of acne vulgaris

Ibrahim, Zainab A.; Gheida, Shereen F.; El-Halaby, Amira R; Hassan, Arwa M.; Mohammed, Dareen A.

doi:10.1080/09546634.2020.1793884

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…A recent study by Ibrahim et al, 16 reported the improvement of active acne lesions after PRP injection. They clarified the strong anti‐inflammatory and the antibacterial effect of PRP in inflamed acne lesion which was confirmed by the histopathological examination.…”

Section: Discussionmentioning

confidence: 94%

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Evaluation of the efficacy and safety of platelet rich plasma injection in treatment of rosacea

Ghoz

Mohamed

Ibrahim

et al. 2021

Dermatologic Therapy

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Rosacea is a chronic relapsing inflammatory skin disease, with a high prevalence among adults. Treatment of rosacea is difficult, with high rate of recurrence. Due to the strong anti‐ inflammatory and antibacterial effects of platelet rich plasma (PRP), it was used in the medicine for treating many inflammatory diseases. To evaluate the role of PRP injection in treatment of rosacea. The study was carried on 40 patients with rosacea. They were treated by PRP injection in right side of the face (group A) and platelet poor plasma injection in left side (group B). They underwent one session every 2 weeks for 3 months (6 sessions). The patients were assessed clinically before and after treatment by the rosacea grading scale. Skin biopsies were taken to evaluate the clinical results. There was a statistically significant decrease in rosacea grading scale after treatment with PRP injection, 50% of the patients showed excellent improvement and 50% showed good improvement. The improvement was significantly better in group A than B. There was marked decrease in inflammatory cells by hematoxylin and eosin stain, and decrease in expression of nuclear factor kappa βeta after treatment with PRP. PRP was effective and safe technique in treatment of rosacea and alternative to other systemic modalities, especially if they are contraindicated.

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Section: Discussionmentioning

confidence: 94%

“…However, it could be suggested through the anti-inflammatory, the antibacterial and vasculogenic effect of PRP. However, other studies 15,16 were done to evaluate the role of PRP in other inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy and safety of platelet rich plasma injection in treatment of rosacea

Ghoz

Mohamed

Ibrahim

et al. 2021

Dermatologic Therapy

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“…The preparation of ICAM is a patent‐pending process referred to the Egyptian Atomic Energy Authority). Then, the depth of derma pen was increased to 1.5 mm moving all over the area until uniform pinpoint bleeding was seen. Side (B)—left side: PRP was prepared by the double spin methods as described by details by Ibrahim et al 11 0.5–1 ml of PRP was topically applied on the left side and increased the depth of derma pen to 1.5 mm moving all over the area until uniform pinpoint bleeding was noticed (this was taken as the end point).…”

Section: Methodsmentioning

confidence: 99%

Facial rejuvenation by microneedling with irradiated amniotic collagen matrix compared to platelet rich plasma

Basyoni

Mohammed

Radwan

et al. 2022

Dermatologic Therapy

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Many modalities are used for treatment of facial wrinkles, such as microneedling that enhances collagen production, and platelet-rich plasma (PRP) which contains concentrated levels of growth factors. The human amniotic membrane isolated from the placentae of donors (during elective cesarean sections) has high levels of growth factors that help in rejuvenation by improving the migration and proliferation of keratinocytes, fibroblasts and increased collagen synthesis. Was to confirm the efficacy of irradiated amniotic collagen matrix (IACM) versus platelet rich plasma (PRP) delivered via microneedling in facial rejuvenation. The present study included 20 patients with facial wrinkles divided into two groups using split face technique: Group A subjected to microneedling with topical IACM on the right side of the face. Group B subjected to microneedling with topical PRP on the left side of the face. Patients received six sessions 2 weeks apart. Photos by Antera camera and skin biopsies were taken to

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“…[43,44] Additionally, it has an antibacterial role through presence of plasma proteins in platelet-poor plasma fraction (e.g., fibrinogen, prothrombin and fibronectin) [43] and antimicrobial peptides such as hBD-2 in PRP concentrate in addition to leukocyte action of white blood cells improving papulopustular and nodulocystic lesions. [43,45,46] Therefore, PRP demonstrated significant reduction in bacterial growth after 8 hours with more reduction after 24 hours for Staphylococcus (S) aureus, S. epidermidis, methicillin-resistant S. aureus and C. acnes compared with the whole-blood control group. [47] Also, hepatocyte growth factor has both anti-fibrotic and…”

Section: Platelet-rich Plasma (Prp)mentioning

confidence: 98%

“…[55] Devices targeting C. acnes C. acnes, the main pathogenic element in acne vulgaris, is a gram-positive microaerophilic cutaneous bacterium that produces endogenous porphyrins (uroporphyrin, protoporphyrin and coproporphyrin III), absorbing light energy at the near UV and blue light spectrum [56] Consequently, reactive free radical species released, leading to bacterial destruction as the singlet oxygen that anti-inflammatory actions that are mediated by disruption of transcription factor nuclear factor kappa B signaling, which acts as an inflammatory regulator besides its anti-inflammatory effects on COX-1, 2 and prostaglandin E2 production. [45] Zhu et al, [48] studying the efficacy of PRP in adjunct with ablative erbium fractional laser for management of facial acne scars, found that the already present acne lesions were cured in addition to absence of wounds after laser resurfacing, indicating that PRP has an advantage in regulating inflammation, increasing healing by inhibiting C. acnes and accelerating re-epithelialization and collagen remodeling. Recently, Moftah et al [49] reported significant improvement of both non-inflammatory and inflammatory lesions in adolescents as well as post-adolescent patients after PRP therapy [Figure 1].…”

Section: Comedone Extractionmentioning

confidence: 99%

Non-pharmacologic treatment for acne vulgaris

Moftah

2022

CSDM

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Early rapid treatment of acne vulgaris is mandatory for improving the psychological behavior of acne patients and to avoid the occurrence of post acne scars that are still more frustrating and challenging condition in their treatment up till now. The current first line of treatment of acne vulgaris is the conventional pharmacological therapy including; keratolytics, topical or oral antibiotics, retinoids, and hormonal agents. Meanwhile, the use of this pharmacological therapy is not always beneficial because of poor compliance of the patients, occurrence of side effects of drugs and antibiotic resistance to Cutibacterium (C.) acne with high rate of recurrence. Therefore, non-pharmacological treatment is developed as safe and effective options for treating acne vulgaris. They are applied either as independent treatment modality, an adjunct to pharmacological therapy, or as maintenance therapy. There is no sufficient data on the classification of this treatment category. This review discusses the non-pharmacological therapy in management of acne vulgaris besides efficacy and safety of each type of treatment modality. The most commonly applied non-pharmacological therapies are diet control, counseling, dermocosmetics, comedo extraction, chemical peeling, cryotherapy, chemical peels, platelets rich plasma (PRP), botulinum neurotoxin A (BoNTA), light-based therapy and laser and photodynamic therapy (PDT). Regarding lasers and light sources, they can be subclassified according to their mechanism of action into devices targeting levels of C. acnes, function of the sebaceous unit, or both.

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Platelet rich plasma injection versus topical erythromycin 2% in treatment of acne vulgaris

Cited by 7 publications

References 21 publications

Evaluation of the efficacy and safety of platelet rich plasma injection in treatment of rosacea

Evaluation of the efficacy and safety of platelet rich plasma injection in treatment of rosacea

Facial rejuvenation by microneedling with irradiated amniotic collagen matrix compared to platelet rich plasma

Non-pharmacologic treatment for acne vulgaris

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