Platelet-Rich Plasma (PRP) in Breast Cancer Patients: An Application Analysis of 163 Sentinel Lymph Node Biopsies

Eichler, Christian; Baucks, C; Üner, J.; Pahmeyer, Caroline; Ratiu, Dominik; Gruettner, Berthold; Malter, Wolfram; Warm, M.

doi:10.1155/2020/3432987

Cited by 10 publications

(9 citation statements)

References 20 publications

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“…At present, PRP has been used clinically in many fields such as orthopedic surgery, gynecology, and orthopedics. However, there are few studies on the combined use of TKA and PRP in knee joint therapy [ 19 ]. Accordingly, this study discusses the influence of the combined treatment through a series of indexes such as bone metabolism parameters and limb recovery function, with the view of providing ideas and references for the clinical treatment of traumatic knee arthritis.…”

Section: Introductionmentioning

confidence: 99%

Application Value of Total Knee Arthroplasty plus Platelet-Rich Plasma Therapy in Traumatic Arthritis of the Knee

Zhang

Nie²

2022

Computational and Mathematical Methods in Medicine

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Purpose. This work is aimed at determining the application value of platelet-rich plasma (PRP) therapy plus total knee arthroplasty (TKA) in traumatic arthritis (TA) of the knee. Methods. A retrospective study was conducted on 78 cases of TA of the knee admitted between March 2021 and January 2022 to the Quanzhou First Hospital Affiliated to Fujian Medical University. Based on different treatment methods, 38 cases treated with TKA were assigned to the control group, and 40 cases intervened by PRP+TKA were included in the observation group. The operation time (OT), drainage volume (DV), total blood loss (TBL), incision inflammatory reaction rate, and grade A healing rate were recorded. Besides, preoperative and postoperative knee joint Hospital for Special Surgery (HSS) scores, knee joint pain assessed by visual analogue scale (VAS), knee joint range of motion (ROM), and bone metabolism parameters (osteocalcin (OST), total N-terminal propeptide of type I procollagen (tPINP), and β-isomerized C-terminal telopeptides (β-CTX)) were recorded. Results. The observation group showed reduced postoperative DV and TBL than the control group ( P < 0.05 ). The two cohorts differed insignificantly in OT, incision inflammatory response rate, and grade A healing rate ( P > 0.05 ). The observation group also had better improvement in the HSS score, pain VAS score, and knee ROM ( P < 0.05 ). And higher postoperative OST and tPINP levels while lower β-CTX were determined in the observation group ( P < 0.05 ). Conclusions. PRP+TKA can validly improve the levels of bone metabolism markers in patients with TA of the knee and promote their knee functional recovery, with favorable safety.

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Section: Introductionmentioning

confidence: 99%

Application Value of Total Knee Arthroplasty plus Platelet-Rich Plasma Therapy in Traumatic Arthritis of the Knee

Zhang

Nie²

2022

Computational and Mathematical Methods in Medicine

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“…Accordingly, we evaluated PRP in sentinel node biopsy procedures for breast cancer patients in terms of complication rates and oncological short-term follow-up. No increase in local recurrence rates and a decrease in complication rates were documented [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…No increased rate of local recurrence was observed during the 30-month follow-up. Lower complication rates were registered after the use of ACP ® (Autologous Conditioned Plasma)/PRP compared to the control group, although this difference was not significant [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Platelet-rich plasma (PRP) in oncological patients: long-term oncological outcome analysis of the treatment of subcutaneous venous access device scars in 89 breast cancer patients

Eichler

Üner

Thangarajah

et al. 2022

Arch Gynecol Obstet

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Purpose Platelet-rich plasma (PRP) is widely used product, and meta-analyses showed this product to be beneficial when applied to a wound area. This study group has already demonstrated increased patient satisfaction and lower complication rates in breast cancer patients who received PRP after removal of their subcutaneous venous access device. This work is a follow-up analysis focusing on oncologic safety. Currently, there is no long-term data on the use of PRP products in cancer patients available yet. Methods Between the years 2012–2016, venous access device removal was supported with the application of Arthrex ACP® (Autologous Conditioned Plasma)—a PRP product to improve the wound-healing process. All surgeries were performed in the breast cancer center of the municipal hospital of Cologne, Holweide, Germany. 35 patients received an application of Arthrex ACP® after port removal compared to the control group of 54 patients. Endpoints were local recurrence-free, distant recurrence-free as well as overall survival. Results Median follow-up was 45 months. No (0) adverse events were shown for cancer recurrence within the subcutaneous venous access device scar area. Thus, there seems to be no local oncogenic potential of the PRP product. All other endpoints as well as any-cause death numerically favor PRP use. Conclusion PRP products such as Arthrex ACP® seem to be oncological inert when applied after removal of subcutaneous access devices. This is the first study providing long-term data about overall survival, distant recurrence-free and local recurrence-free survival after applying PRP in high-risk cancer patients.

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“…17 Regarding the possible negative effects of growth factors on an area with a history of cancer, there are in vitro studies 20 that rule out the migration of stem cells or PRP to malignant cells, and clinical studies of the use of PRP in areas of radiated cancer, do not find neoplastic stimulation. 17,21,22…”

Section: Discussionmentioning

confidence: 99%

Platelet rich plasma, in the treatment of sexual disfunction afther pelvic radiotherapy for cancer

Melo¹

2022

OGIJ

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Pelvic radiotherapy in women with cancer is a cause of sexual dysfunction with consequent alteration in their quality of life. Currently there is no adequate therapeutic method to solve it. Platelet-rich (PRP) plasma has been shown to have reparative capacity in tissues that have suffered damage and improves their functionality. We present a case where it was possible to improve the rates of sexual function and vaginal health with the application of PRP. The use of PRP in patients with genital sequelae after radiotherapy is a promising therapeutic method, which requires further studies with an adequate number of patients.

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Platelet-Rich Plasma (PRP) in Breast Cancer Patients: An Application Analysis of 163 Sentinel Lymph Node Biopsies

Cited by 10 publications

References 20 publications

Application Value of Total Knee Arthroplasty plus Platelet-Rich Plasma Therapy in Traumatic Arthritis of the Knee

Application Value of Total Knee Arthroplasty plus Platelet-Rich Plasma Therapy in Traumatic Arthritis of the Knee

Platelet-rich plasma (PRP) in oncological patients: long-term oncological outcome analysis of the treatment of subcutaneous venous access device scars in 89 breast cancer patients

Platelet rich plasma, in the treatment of sexual disfunction afther pelvic radiotherapy for cancer

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