Platelet Serotonin is Decreased by Treatment with the Serotonin Reuptake Inhibiting Antidpressant Drug Fluoxetine

Abstract

7Panti-PDGF-BB and anti-bFGF were maintained a t levels approximately 10-fold higher than those required t o neutralise the mitogenic and chemotactic effects of 5 ng/ ml o f PDGF-BB, or bFGF in-vitro. Used singly, anti-PDGF IgG treatment (n=8) was associated with a 55.6% reduction i n intimal area and a 48.7% reduction i n intimal: medial area ratio; anti-bFGF IgG administration (n.8) caused a 55.6% reduction intimal area, and a 50.1% reduction i n intimal: medial area ratio. Treatment with a combination of these antibodies (n.9) resulted in a 89% reduction in intimal area (p<O.Ol), and a 94% reduction in intimal: medial area r a t i o (p<O.Ol). The l a t t e r was also associated with a significant increose I n intimal cell density compared t o control values (n.9) (14.2t1.6X103/mm2 v 7.8i0.8X103/mm2; p<O.Ol). Our results suggest that in t h i s particular model, PDGF-BB and bFGF are the principal factors controlling neointimal smooth muscle cell and extracellular matrix accumulation, and that these growth factors are probably operating via separate mechanisms.