Platelet serotonin levels in panic disorder

Balon, Richard; Pohl, Robert; Yeragani, V.; Rainey, John M.; Oxenkrug, Gregory F.

doi:10.1111/j.1600-0447.1987.tb02794.x

Cited by 20 publications

(9 citation statements)

References 12 publications

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“…Elevations (Giannini et al, 1983;Davis et al, 1985) as well as decreases (Evans et al, 1985) of plasma serotonin, and decreased urinary 5-HIAA (Giannini et al, 1983), have been reported in small groups of anxious individuals. Platelet serotonin uptake has been reported to be abnormal in panic patients (Norman et al, 1986), but platelet serotonin levels were normal (Balon et al, 1987). Finally, plasma HVA, a metabolite of dopamine, was not significantly elevated in panic patients (Roy-Byrne et al, 1986a); however, a bimodal distribution was observed, with the most anxious patients tending to have higher concentrations.…”

Section: Psychoendocrine Findingsmentioning

confidence: 93%

Systemic hormonal and physiological abnormalities in anxiety disorders

Cameron

Nesse

1988

Psychoneuroendocrinology

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Among the studies of systemic hormonal and physiological abnormalities associated with anxiety disorders, the most consistent and extensive findings suggest (a) peripheral adrenergic hyperactivity (including increases in norepinephrine but not epinephrine) and functional dysregulation, (b) increased incidence of mitral valve prolapse in panic patients, and (c) normal suppressibility of the hypothalamic-pituitary-adrenal cortical endocrine system with dexamethasone in panic patients. Other less-certain findings include (a) increased circulating concentrations of plasma ACTH and/or cortisol, and prolactin, in panic patients, (b) increased platelet monoamine oxidase activity in generalized anxiety and/or panic patients, (c) decreased gonadal axis activity in some anxious individuals, (d) decreased nighttime melatonin plasma concentrations in panic patients, and (e) peripheral alpha 2 and beta-adrenoreceptor down-regulation, with normal serotonin binding parameters. These findings, taken together, provide tentative support for dysfunction in adrenergic and GABAergic central nervous system mechanisms in people with anxiety disorders. Abnormal anxiety and normal stress both show evidence of adrenergic hyperactivity; however, there appear to be differences in hormonal profiles, especially the apparent lack of increase of epinephrine during panic attacks, as well as differences in the reactivity of the system, and in the "trigger" mechanisms which determine when the response occurs.

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Section: Psychoendocrine Findingsmentioning

confidence: 93%

Systemic hormonal and physiological abnormalities in anxiety disorders

Cameron

Nesse

1988

Psychoneuroendocrinology

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“…The literature regarding serotonergic function in anxiety disorders is in disagreement. In PD, platelet 5‐HT uptake has been reported to be abnormally elevated (146), normal (147) or abnormally reduced (148). Platelet imipramine binding (to a site related to the 5‐HT transporter site) did not differ in the PD group relative to those in the control group (149, 150).…”

Section: Serotonergic Function In Anxiety Disordersmentioning

confidence: 99%

Neuroanatomical circuits modulating fear and anxiety behaviors

Charney

2003

Acta Psychiatr Scand

249

155

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Objective: Our understanding of the neurobiology of anxiety disorders, although not complete, has advanced significantly with the development and application of genetic, neuroimaging and neurochemical approaches. Method: The neuroanatomical basis of anxiety disorders is reviewed with particular focus on the amygdala and the temporal and prefrontal cortex. The functional anatomical correlates of anxiety disorders such as panic disorder, specific phobias and post‐traumatic stress disorder are also discussed. Results: Functional neuroimaging studies in patients with anxiety disorders have shown neurophysiological abnormalities during symptom provocation tests, implicating the limbic, paralimbic and sensory association regions. The involvement of neurotransmitters such as serotonin and norepinephrine in depressive disorders is well established. Antidepressants that affect these neurotransmitter systems have also been shown to be useful in the treatment and management of patients with anxiety disorders. The role of serotonin and norepinephrine in the pathophysiology of anxiety disorders is reviewed. In addition, the involvement of the stress hormone corticotropin‐releasing hormone, the peptide cholecystokinin and the amino acid transmitter γ‐amino butyric acid in anxiety disorders is reviewed. Conclusion: The inconsistency in the results of biologic investigations of anxiety disorders highlights the importance of addressing the neurobiologic heterogeneity inherent within criteria‐based, psychiatric diagnoses. Understanding of this heterogeneity will be facilitated by the continued development and application of genetic, neuroimaging and neurochemical approaches that can refine anxiety disorder phenotypes and elucidate the genotypes associated with these disorders. Application of these experimental approaches will also facilitate research aimed at clarifying the mechanisms of anti‐anxiety therapies.

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“…Evans and coworkers [26] reported lowered plasma serotonin concentrations while Balon et a1 [27] found no difference in platelet serotonin concentrations between panic patients and controls. The present study has shown an abnormality of serotonin function in panic disorder.…”

Section: Discussionmentioning

confidence: 99%

Platelet Serotonin Uptake in Panic Disorder: Comparison with Normal Controls and the Effect of Treatment

Norman

Gregory

Judd

et al. 1988

Aust N Z J Psychiatry

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Platelet serotonin uptake was measured in 59 patients with panic attacks and compared to 26 controls. Scatchard analysis of the data showed that the maximal rate of uptake (Vmax) of serotonin was significantly higher in patients than controls. The affinity constant (Km) was not different. In a sub-group of 24 patients, benzodiazepine treatment did not alter the kinetics of platelet serotonin uptake. These findings suggest an abnormality in serotonergic function in patients with panic attacks. Insofar as the platelet is a model of central neuronal function they support serotonergic hyperactivity as a biochemical basis of panic attacks.

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Platelet serotonin levels in panic disorder

Abstract: Platelet serotonin levels were examined in 18 patients with panic disorder and compared to platelet serotonin levels of eight healthy controls. There was no statistically significant difference in the platelet serotonin levels between the two groups.

Cited by 20 publications

References 12 publications

Systemic hormonal and physiological abnormalities in anxiety disorders

Systemic hormonal and physiological abnormalities in anxiety disorders

Neuroanatomical circuits modulating fear and anxiety behaviors

Platelet Serotonin Uptake in Panic Disorder: Comparison with Normal Controls and the Effect of Treatment

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