Platelet transfusion reactions do not occur more often in recipients transfused with apheresis versus buffy coat platelet concentrates

Cserti‐Gazdewich, Christine; Escorcia, Alioska; Pendergrast, Jacob; Lieberman, Lani; Skeate, Robert; Lin, Yulia; Callum, Jeannie

doi:10.1111/trf.13884

Cited by 4 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our adult dose platelet concentrates are predominantly buffy coat pools (four whole blood donor derived) with single donor apheresis platelets. The ratio delivered to our centre by Canadian Blood Services is presently 10:1, which has been rising from previous ratios (3:1) over the last several years [1].…”

Section: Canadamentioning

confidence: 95%

International Forum on Transfusion Practices in Haematopoietic Stem‐Cell Transplantation: Responses

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Canadamentioning

confidence: 95%

International Forum on Transfusion Practices in Haematopoietic Stem‐Cell Transplantation: Responses

et al. 2021

View full text Add to dashboard Cite

show abstract

“…At the UHN, 3-5% of blood product recipients suffer transfusion reactions, suggesting a steadfast reporting rate. 58,59 Inpatients and outpatients across various healthcare settings are included, and each enrolled patient undergoes protocol-defined multi-dimensional biomarker sampling within 24 hours of the TR onset in accordance with timing-related resources, while all enrolees undergo systematic chart abstractions for data fields pre-specified in the case report form. Eligible CRTRs are those occurring within 12 hours of a transfusion, and are defined as having either of the following: hypoxic desaturation, and/or cardio/pulmonary distress, as characterized by at least 2 of: subjective difficulty breathing or chest pain, and/or objective signs including: (any one or more of): tachypnea, increased work of breathing, new or worsened adventitious breath sounds, new or worsened tracheal fluid outputs, cardiovascular changes of significance (tachycardia, hyper-or hypotension, jugular or central venous pressure rises, or cutaneous signs of shock/hypoperfusion).…”

Section: Study Population and Sampling Methodsmentioning

confidence: 99%

The transfusion-associated dyspnea prospective observation and laboratory assessment study: a protocol for investigating and disambiguating cardiopulmonary and high-grade febrile transfusion reactions in adults

McVey

Saeed²,

Siddiqui³

et al. 2023

Int J Clin Trials

View full text Add to dashboard Cite

Background: Cardiorespiratory transfusion reactions drive most transfusion-related morbidity and mortality. Transfusion-associated circulatory overload and transfusion-related acute lung injury have established causes, important impacts, mitigation options, and revised definitions, while non-conforming CRTRs fall into a category known as transfusion-associated dyspnea. Though procedures to investigate high-risk febrile transfusion reactions are typically rooted in detecting incompatibility or bacterial contamination, a common standard for examining CRTRs is lacking. CRTRs are further challenged by charting limitations, confounding (or enhanced susceptibility) by comorbidities, and/or overlapping insults. Deeper profiling of CRTRs could improve categorizations, reveal best-value diagnostics, and decipher the nature of (and/or minimize) reactions coded as TAD. Methods: The primary objective of this multi-center study is to reduce uncertainty in final conclusions drawn on CRTRs (cases), defined by dyspnea with objective disturbances and/or significant hemodynamic insults, with/without fever (±F). HRFTRs (controls) represent higher-grade F (T≥39°C or chills/rigors or lower-grade F (≥38°C by +Δ1°C) with non-respiratory effects). Patients (goal: 200) consent to additional sampling (≤24h post-TR) to identify contributing factors in case/control presentations, and in diagnostic groups (TRALI, TACO±F, TAD). Mechanistic axes of interest are cardiorenal, hemolytic, leukoagglutinating, biolipid, vasoactive, and inflammatory. Secondary goals include elucidation of real-life “insult-multiplicity” in CRTRs, tests of greatest yield, and distinguishing features in TRALI/TACO/TAD. Conclusions: A deep systematic CRTR probe may not only reduce diagnostic uncertainty but frame biomarker performance and pathologic signatures in definition-specific CRTRs. The re-classifiability or biology of TAD may be better understood. High-quality, mechanistic, true-to-quantity hemovigilance better exposes burdens and management options. Trial Registration: The trial is registered with ClinicalTrials.gov. with registry number NCT04267029.

show abstract

“…All blood components, which were provided by Canadian Blood Services, have been subject to universal prestorage LR since 1999. LR RBCs have saline‐adenine‐glucose‐mannitol (SAGM) added, whereas adult‐dose PLT concentrates either comprise buffy coat‐derived pools (of four) or apheresis products; pathogen‐inactivation or additive solutions are not yet features of this supply …”

Section: Methodsmentioning

confidence: 99%

Feeling the burn: the significant burden of febrile nonhemolytic transfusion reactions

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

Platelet transfusion reactions do not occur more often in recipients transfused with apheresis versus buffy coat platelet concentrates

Cited by 4 publications

References 4 publications

International Forum on Transfusion Practices in Haematopoietic Stem‐Cell Transplantation: Responses

International Forum on Transfusion Practices in Haematopoietic Stem‐Cell Transplantation: Responses

The transfusion-associated dyspnea prospective observation and laboratory assessment study: a protocol for investigating and disambiguating cardiopulmonary and high-grade febrile transfusion reactions in adults

Feeling the burn: the significant burden of febrile nonhemolytic transfusion reactions

Contact Info

Product

Resources

About