Platelets and diabetes mellitus

Santilli, Francesca; Simeone, Paola; Liani, Rossella; Davı̀, Giovanni

doi:10.1016/j.prostaglandins.2015.05.002

Cited by 97 publications

(80 citation statements)

References 143 publications

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“…It is well known that platelets from diabetic patients are hyperreactive [2, 4]. Thus, the present study showed that platelet stimulation induced more marked elevation of platelet P-selectin expression, suggesting intensified platelet secretion upon activation.…”

Section: Discussionsupporting

confidence: 65%

“…Type 2 diabetes mellitus (T2DM) is associated with a high risk of cardiovascular complications due to diabetic angiopathy [1, 2]. The development of diabetic angiopathy and atherosclerosis involves multiple mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…Platelets from T2DM patients are hyperactive [2, 4]. There are more circulating activated platelets and platelet-leukocyte aggregates in T2DM patients [4, 5].…”

Section: Introductionmentioning

confidence: 99%

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Unaltered Angiogenesis-Regulating Activities of Platelets in Mild Type 2 Diabetes Mellitus despite a Marked Platelet Hyperreactivity

et al. 2016

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Type 2 diabetes mellitus (T2DM) is associated with platelet dysfunction and impaired angiogenesis. Aim of the study is to investigate if platelet dysfunction might hamper platelet angiogenic activities in T2DM patients. Sixteen T2DM patients and gender/age-matched non-diabetic controls were studied. Flow cytometry and endothelial colony forming cell (ECFC) tube formation on matrigel were used to assess platelet reactivity and angiogenic activity, respectively. Thrombin receptor PAR1-activating peptide (PAR1-AP) induced higher platelet P-selectin expression, and evoked more rapid and intense platelet annexin V binding in T2DM patients, seen as a more rapid increase of annexin V+ platelets (24.3±6.4% vs 12.6±3.8% in control at 2 min) and a higher elevation (30.9±5.1% vs 24.3±3.0% at 8 min). However, PAR1-AP and PAR4-AP induced similar releases of angiogenic regulators from platelets, and both stimuli evoked platelet release of platelet angiogenic regulators to similar extents in T2DM and control subjects. Thus, PAR1-stimulated platelet releasate (PAR1-PR) and PAR4-PR similarly enhanced capillary-like network/tube formation of ECFCs, and the enhancements did not differ between T2DM and control subjects. Direct supplementation of platelets to ECFCs at the ratio of 1:200 enhanced ECFC tube formation even more markedly, leading to approximately 100% increases of the total branch points of ECFC tube formation, for which the enhancements were also similar between patients and controls. In conclusion, platelets from T2DM subjects are hyperreactive. Platelet activation induced by high doses of PAR1-AP, however, results in similar releases of angiogenic regulators in mild T2DM and control subjects. Platelets from T2DM and control subjects also demonstrate similar enhancements on ECFC angiogenic activities.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

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Unaltered Angiogenesis-Regulating Activities of Platelets in Mild Type 2 Diabetes Mellitus despite a Marked Platelet Hyperreactivity

et al. 2016

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“…Dyslipidemia, obesity and systemic inflammation associated with T2DM may also contribute to platelet hyperreactivity. A clinical study of platelet inhibition in 157 cardiovascular disease patients treated with the platelet inhibitor clopidogrel, revealed a lower response to the drug in DM patients and in patients with high BMI (≥25 kg/m 2 ) and a significant interaction between DM and elevated plasma fibrinogen [53,54,55]. Fibrinogen mediates platelet plug formation and stabilizes clots through polymerization of fibrin produced by thrombin cleavage of fibrinogen that are elevated in DM patients [37,52].…”

Section: A Role For Platelets In the Pathology Of Diabetes-inducedmentioning

confidence: 99%

Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation

Jagadapillai

Rane

Lin

et al. 2016

IJMS

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Diabetes is strongly associated with systemic inflammation and oxidative stress, but its effect on pulmonary vascular disease and lung function has often been disregarded. Several studies identified restrictive lung disease and fibrotic changes in diabetic patients and in animal models of diabetes. While microvascular dysfunction is a well-known complication of diabetes, the mechanisms leading to diabetes-induced lung injury have largely been disregarded. We described the potential involvement of diabetes-induced platelet-endothelial interactions in perpetuating vascular inflammation and oxidative injury leading to fibrotic changes in the lung. Changes in nitric oxide synthase (NOS) activation and decreased NO bioavailability in the diabetic lung increase platelet activation and vascular injury and may account for platelet hyperreactivity reported in diabetic patients. Additionally, the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway has been reported to mediate pancreatic islet damage, and is implicated in the onset of diabetes, inflammation and vascular injury. Many growth factors and diabetes-induced agonists act via the JAK/STAT pathway. Other studies reported the contribution of the JAK/STAT pathway to the regulation of the pulmonary fibrotic process but the role of this pathway in the development of diabetic lung fibrosis has not been considered. These observations may open new therapeutic perspectives for modulating multiple pathways to mitigate diabetes onset or its pulmonary consequences.

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“…49 Platelet activation plays a key role in athero-thrombosis in T2DM and increased in vivo platelet activation with enhanced thromboxane biosynthesis has been reported in patients with impairment of glucose metabolism even in the earlier stages of disease and in the preclinical phases. 50 In healthy subjects, without DM, the induction of acute hyperglycaemia can lead to increased platelet reactivity and platelet activation as evidenced by increased markers such as soluble P-selectin and CD40-ligand. 35,38 Exposure of platelets to hyperosmolar solutions may also lead to increased reactivity, suggesting that hyperglycaemia may have a direct osmotic effect.…”

Section: Markers Of Blood Coagulation Plasma Plateletsmentioning

confidence: 99%

Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

Agu

2018

JMH

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Background: The WHO defined ‘diabetes mellitus’ (DM) as a metabolic disorder characterised by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from the defect in insulin secretion, or inaction, or both. When not identified early and controlled, acute and chronic life-threatening consequences may result. Identifying DM early for treatment and management, as well as clinically monitoring recovery and improvement during treatment, involves the assessments of biomarkers. The types, choice, sensitivity and descriptive information trends of these biomarkers are very important. Aim: Some prognostic biomarkers and parameters that this review identified include glycated haemoglobin, white blood cells, mean neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, total leukocytes and neutrophils, plasma low-density lipoprotein, high-density lipoprotein and very low-density lipoprotein, platelet, fibrinogen, D-dimer and C-reactive proteins. Results: These parameters display increases in DM, while red blood cell, haemoglobin concentration, activated partial thromboplastin time, prothrombin time and partial thromboplastin time are decreased. Conclusion: With sound knowledge of the variations of these markers and parameters, observed reversal during treatment and management of DM and its complications can be better monitored, and guided decisions can be made.

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Platelets and diabetes mellitus

Cited by 97 publications

References 143 publications

Unaltered Angiogenesis-Regulating Activities of Platelets in Mild Type 2 Diabetes Mellitus despite a Marked Platelet Hyperreactivity

Unaltered Angiogenesis-Regulating Activities of Platelets in Mild Type 2 Diabetes Mellitus despite a Marked Platelet Hyperreactivity

Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation

Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

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