Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: possible role in sustained platelet activation

Gresele, Paolo; Falcinelli, Emanuela; Loffredo, Francesco; Cimmino, Giovanni; Corazzi, Teresa; Forte, L. A.; Guglielmini, Giuseppe; Momi, Stefania; Golino, Paolo

doi:10.1093/eurheartj/ehq390

Cited by 62 publications

(66 citation statements)

References 38 publications

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“…on May 10, 2018. by guest www.bloodjournal.org From count is widely recognized as a reliable biomarker of inflammation, 30 but PLTs have also been ascribed a role in inflammation due to the production and release of prostaglandins and other substances causing either vasodilation or vasoconstriction. [31][32][33][34] Our study has investigated whether the adherence to a Mediterranean-style diet is a determinant of PLT or WBC count in a healthy population. Our results show that a greater adherence to the MD, measured by 2 widely used dietary scores, is significantly associated with a reduction in either PLT or WBC count in multivariable models controlling for many possible confounders.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study

Bonaccio

Castelnuovo

Curtis

et al. 2014

Blood

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Key Points• Adherence to a Mediterranean diet is associated with reduced platelet and leukocyte counts.• The observed associations are partially explained by the high dietary fiber and antioxidant content of the Mediterranean diet.Platelet (PLT) and white blood cell (WBC) counts are 2 markers of inflammation and have been linked to the risk for cerebrovascular and coronary heart disease. A Mediterranean diet (MD) has been associated with reduced inflammation and mortality for major chronic diseases. We aimed at evaluating the association between the MD and both PLT and WBC counts. This cross-sectional analysis in a population-based cohort study included 14 586 healthy Italian citizens enrolled within the Moli-sani study. Adherence to MD was appraised by either the MD Score (MDS) or the Italian Mediterranean Index (IMI). PLT and WBC counts were both inversely related to MD adherence (MDS: P < .0001 and P 5 .008, respectively). As compared with those with poorer MD adherence, subjects with greater adherence had both reduced odds of being in the highest PLT-count group (MDS: odds ratio 5 0.50; 95% confidence interval, 0.31-0.80) and increased odds of being in the lowest WBC-count group (IMI: odds ratio 5 1.41; 95% confidence interval, 1.07-1.86). The association between WBC count and MDS disappeared when further adjusted for PLT count, whereas the association between PLT count and the MD was not affected by adjustment for WBCs. Food antioxidant and dietary fiber content modified the inverse association between MDS and WBC count and partially accounted for the association with PLTs.

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Section: Discussionmentioning

confidence: 99%

Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study

Bonaccio

Castelnuovo

Curtis

et al. 2014

Blood

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“…Conversely, poor antiplatelet drug response and HPR may be less critical in stable cardiovascular patients owing to lower endothelial thrombogenicity 32,33 and lower platelet activation status. 34 Specific assays may not be as sensitive as aggregation-based assays to the inflammation associated with acute ischemic events. The differences in platelet reactivity assessment between specific and aggregation-based assays are further supported by the marked heterogeneity evidenced in meta-analysis of studies using various platelet function assays.…”

Section: Discussionmentioning

confidence: 99%

Antiplatelet Drug Response Status Does Not Predict Recurrent Ischemic Events in Stable Cardiovascular Patients

et al. 2012

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for the Antiplatelet Drug Resistances and Ischemic Events (ADRIE) Study GroupBackground-The biological response to antiplatelet drugs has repeatedly been shown to predict the recurrence of major adverse cardiovascular events (MACEs). However, most studies involved coronary artery disease patients with recent vessel injury shortly after the initiation of antiplatelet therapy. Data on stable cardiovascular patients are scarce, and the added predictive value of specific assays (the vasodilator phosphoprotein assay for the clopidogrel response and serum thromboxane B2 for the aspirin response) and aggregation-based assays relative to common predictors has rarely been addressed. Methods and Results-Stable cardiovascular outpatients participating in the Antiplatelet Drug Resistances and IschemicEvents (ADRIE) study (nϭ771) were tested twice, at 2 separate visits, with specific and aggregation-based assays. Follow-up lasted 3 years, and Ͻ1% of patients were lost to follow-up. MACEs were adjudicated by an independent committee. Multivariate survival analyses included relevant variables identified in univariate analysis and platelet function test results. The C-index was used to express the prognostic value of various multivariate models. MACEs, the primary end point, occurred in 16% of patients. Hypertension, smoking, older age, and elevated low-density lipoprotein cholesterol were predictive of MACE recurrence, with a C-index of 0.63 (PϽ0.001). Neither the specific nor the aggregation-based assays added significant predictive value for the primary end point. Conclusions-Biological

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“…It is a fascinating shape with unusual symmetry named by the German mathematician Johannes Kepler in 1611. 7 It is even believed by some to be a sacred geometry with mystical properties. Although its vertices seem to have no order, in actuality, the vertices form the corners of a cube.…”

Section: Mmp-9 In Platelets: Maybe Maybe Notmentioning

confidence: 99%

Response: MMP-9 in platelets: maybe, maybe not

Falcinelli

Bury

Tolley

et al. 2011

Blood

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megakaryocyte and platelet lysates should take into consideration that the MMP-2, -3, and -9 activities may be significantly inhibited by calcium chelators and phosphotyrosine phosphatase inhibitors. More cautious use of these MMP inhibitors will provide useful insights to understand how cytoplasm and nuclear MMPs (F.M. and V.M., unpublished observations, October 2011) may be transferred from megakaryocytes to platelets in physio-pathologic conditions. Ferdinando Mannello

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Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: possible role in sustained platelet activation

Abstract: Matrix metalloproteinase-2 is released in the coronary circulation of ACS patients, derives in part from activated platelets, and may contribute to sustained intracoronary platelet activation.

Cited by 62 publications

References 38 publications

Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study

Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study

Antiplatelet Drug Response Status Does Not Predict Recurrent Ischemic Events in Stable Cardiovascular Patients

Response: MMP-9 in platelets: maybe, maybe not

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