Platelets rich plasma versus minoxidil 5% in treatment of alopecia areata: A trichoscopic evaluation

Taieb, Moustafa A El; Ibrahim, Hassan; Nada, Essam; Al-Din, Mai Seif

doi:10.1111/dth.12437

Cited by 90 publications

(95 citation statements)

References 34 publications

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“…The role of trichoscopy in the therapeutic monitoring of alopecia areata was also emphasized . Hegde et al .…”

Section: Trichoscopy In Monitoring Treatment Efficacy Of Alopecia Areatamentioning

confidence: 99%

“…reported a reduction in exclamation mark hairs, black dots, yellow dots and broken hairs combined with an increased number of short vellus hairs and new vessels in patients with alopecia areata treated with diphenylcyclopropenone. According to El Taieb et al ., patients with alopecia areata treated with 5% minoxidil solution presented an increased number of short vellus hairs and decreased number of yellow dots. However, an increased number of fully pigmented hairs and the reduction in short vellus hairs and yellow dots were reported in patients treated with platelet‐rich plasma.…”

Section: Trichoscopy In Monitoring Treatment Efficacy Of Alopecia Areatamentioning

confidence: 99%

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Trichoscopy of alopecia areata: An update

Waśkiel

Rakowska

Sikora

et al. 2018

The Journal of Dermatology

113

100

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The diagnosis of alopecia areata is usually based on clinical manifestations. However, there are several hair and scalp disorders that share similar clinical features with alopecia areata, such as tinea capitis, trichotillomania or traction alopecia. Trichoscopy as a fast, non-invasive and easy-to-perform technique may help to identify subtle details and establish the correct diagnosis. The aim of this review is to present the spectrum of trichoscopic findings in alopecia areata. A systematic review of the published work was performed by searching the PubMed, Scopus and EBSCO databases, complemented by a thorough hand search of reference lists. Of 427 articles retrieved, 30 studies were eligible for quantitative analysis. The reported features of alopecia areata were: yellow dots (6-100% patients), short vellus hairs (34-100%), black dots (0-84%), broken hairs (0-71%) and exclamation mark hairs (12-71%). Tapered hairs (5-81%) were reported in few studies, but a relatively high frequency of this finding in alopecia areata may indicate their important role in the differential diagnosis of hair loss. Rarely reported features, which include upright regrowing hairs (11-96%), pigtail (circle) hairs (4-61%) and Pohl-Pinkus constrictions (2-10%), may also be helpful in the diagnosis of alopecia areata. There is no pathognomonic trichoscopic marker for alopecia areata and the most common trichoscopic features are not the most specific. Therefore, the diagnosis should be based on the coexistence of several trichoscopic findings, not on the presence of a single feature.

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“…The role of trichoscopy in the therapeutic monitoring of alopecia areata was also emphasized . Hegde et al .…”

Section: Trichoscopy In Monitoring Treatment Efficacy Of Alopecia Areatamentioning

confidence: 99%

Section: Trichoscopy In Monitoring Treatment Efficacy Of Alopecia Areatamentioning

confidence: 99%

Trichoscopy of alopecia areata: An update

Waśkiel

Rakowska

Sikora

et al. 2018

The Journal of Dermatology

113

100

View full text Add to dashboard Cite

show abstract

“…Contrasted with TrA and placebo, PRP showed more effective on the treatment of AA . Another study to evaluate the efficacy of PRP versus topical minoxidil 5% in the treatment of AA with 90 patients was carried out recently . While they both have significant improvements in hair growth, the PRP‐treated ones had earlier new hair regrowth and better new hair quality than the other two groups.…”

Section: Application Of Prpmentioning

confidence: 99%

Applications and efficacy of platelet‐rich plasma in dermatology: A clinical review

Zhang

Park

Zhou

et al. 2018

J of Cosmetic Dermatology

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The platelet-rich plasma (PRP) has been studied in bone-related applications for accelerating healing, and the proliferation and regeneration of tissue. Now the dermatological indications increase rapidly in recent years. We have reviewed clinical trials, comparative trials, and meta-analysis of PRP on dermatology through key words and reorganized them into facial rejuvenation, hair, scar, vitiligo, and synergistic effect with fractional CO , with a conclusion that PRP has significant improvements in dermatology. But the lack of RCTs and the limit of samples cannot provide sufficient enough evidence for general clinical applications. More RCTs are needed for the increasing demand of new dermatologic therapeutics, and we need adequate samples urgently to make the results more persuasive.

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“…For example, an intra‐control half head treatment study on AGA patients using PRP and placebo showed a statistically significant improvement in the number of anagen hairs in the target area and in total hair density post‐treatment . Pilot studies have also evaluated the efficacy of PRP for treating alopecia areata and were found to improve hair growth . Recent reviews of PRP for the treatment of hair loss conclude that, though clearly still in a nascent stage, the use of PRP for alopecia is promising and the side effects are relatively limited …”

Section: Introductionmentioning

confidence: 99%

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Siah

Guo

Chu

et al. 2020

Experimental Dermatology

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Background Platelet‐rich plasma (PRP), processed from autologous peripheral blood, is used to treat androgenetic alopecia (AGA). Objective To determine the efficacy of PRP for hair growth promotion in AGA patients in a randomized, blinded, placebo‐controlled, pilot clinical trial (NCT02074943). Methods The efficacy of an 8 week, five session, PRP treatment course was determined by measuring hair density and hair caliber changes in 10 AGA affected patients. For each PRP sample, the concentrations of selected growth factors were determined using a multiplex assay system. The clinical results were then correlated with the growth factor concentrations in PRP. Results At 16 weeks, 8 weeks after the last PRP injection, treated areas exhibited increased mean hair density (+12.76%) over baseline compared to placebo (+0.99%). Mean hair caliber decreased in both treated and placebo regions (−16.22% and −19.46%, respectively). Serial analysis of PRP significant variability in concentrations between patients. Overall, there was a positive correlation between GDNF concentration and hair density (P = .004). Trends, though not statistically significant, were also observed for FGF2 and VEGF. Limitations Small sample size and lack of comparative cohorts receiving protocol variations limit confidence in the study data. Conclusions This small pilot clinical trial suggests PRP treatment may be beneficial for AGA. However, the variable hair growth responses between patients indicate there is a significant opportunity to improve PRP therapy protocols for hair growth promotion. The variability in growth factor concentration in PRP suggests standardization of growth factors postprocessing might improve hair growth responses.

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Platelets rich plasma versus minoxidil 5% in treatment of alopecia areata: A trichoscopic evaluation

Cited by 90 publications

References 34 publications

Trichoscopy of alopecia areata: An update

Trichoscopy of alopecia areata: An update

Applications and efficacy of platelet‐rich plasma in dermatology: A clinical review

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

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