Platinum complexes inhibit HER-2 enriched and triple-negative breast cancer cells metabolism to suppress growth, stemness and migration by targeting PKM/LDHA and CCND1/BCL2/ATG3 signaling pathways

Inhibition of SREBP-mediated lipid biosynthesis and activation of multiple anticancer mechanisms by platinum complexes: Ascribe possibilities of new antitumor strategies

“…We investigated many salicylaldimine type of ligands derived metal complexes and checked their anticancer properties. [43][44][45][46][47][48][49][50][51] The anticancer properties of all those complexes were comparable to cisplatin. Among them the most effective class of complexes observed was the SNO donor salicylaldimine ligand derived Pt(II) complexes.…”

“…C1 crystallized in monoclinic while C3 in triclinic crystal system where Pt(II) adopted square planner environment. In both of these crystals the coordinated functions were SNO atoms of main salicylaldimine ligand in which O atom was covalently bonded while SN were coordinate covalently bonded to Pt(II) metal [43]. The fourth coordinate of Pt(II) was completed by N donor atom of co-ligand pyridine that was coordinate covalently bonded to metal (Figure 4 and 5).…”

“…Each complex (C1-C8) was prepared from the precursor complex (PC1-PC8) [43], the ancillary chloride ligand was abstracted using AgBF4 in acetonitrile and successively treated with excess pyridine (coligand) to get C1-C8 in excellent isolated yields. These complexes were structurally characterized by 1 H, 13 C NMR, UV-vis and FT-IR spectroscopy and HR-ESI mass spectrometry (ESI Figure S1-S33).…”

“…Among them the most effective class of complexes observed was the SNO donor salicylaldimine ligand derived Pt(II) complexes. [43,44] We are further working on their modifications to search other related isomers those could be easily synthesized and show enhance anticancer effect as compared to already used platinum anticancer drugs.…”

“…We recently reported platinum anticancer complexes [43] with potent anticancer activities, in this study these complexes were further modified with co-ligand pyridine. This modification further increased the anticancer potentials of these complexes.…”