Platinum Compounds: A Hope for Future Cancer Chemotherapy

Abstract

The discovery of cis-platin and its second and third generation analogues created a hope in cancer chemotherapy. Cis-platin and its second generation analogue carboplatin have been used for the treatment of some cancers from a long time. The third generation analogues have superior anti-cancer profiles for curing a few cancers. Unfortunately, certain side effects such as renal impairment, neurotoxicity and ototoxicity etc. are associated with these drugs. But, combination therapy makes these analogues more effective with fewer side effects. In addition, the results of some ongoing clinical trials will make the safety profile clear in near future. The present article describes the current status of cis-platin and its analogues in cancer chemotherapy. In addition, special emphasis has been made on cis-platin discovery, development of second (carboplatin, oxaliplatin, nedaplatin) and third (lobaplatin, heptalatin) generation analogues, comparison of their chemotherapies, mechanism of action, therapeutic status, recent developments and chronology. Moreover, attempts have been made to describe the future perspectives of these drugs in the cancer treatment.

Cytotoxicity of synthesized 1,4-naphthoquinone analogues on selected human cancer cell lines

“…[19][20][21] Although major advances have been made by researchers but the medical need is still largely unmet due to many factors; among which are the lack of selectivity of conventional drugs leading to toxicity, the metastatic spreading, and multi -drug resistance. [22][23][24][25][26][27] Novel and selective anticancer agents are urgently required due to problems associated with currently available anticancer drugs. The plant Euclea natalensis (A.…”

Protective Effect of Korean Red Ginseng on Cisplatin Ototoxicity: Is It Effective Enough?

“…Age-related hearing loss, noise-induced hearing loss, and ototoxicity has been shown to occur as a result of an apoptotic process [3][4][5][6][7] . KRG extracts, or its specific saponins, were shown to have antiapoptotic and antioxidant properties in various tissues both in vitro and in vivo [8] .…”

“…Ototoxicity could lead to language and speech disabilities in young children [1][2] . The mechanism of CDDP-induced ototoxicity is apoptosis, and outer hair cells, stria vascularis, and spiral ganglion neurons are mainly affected [3][4][5][6][7] .…”

Synthesis, Characterization, Electrochemical Behaviour, DNA Binding and Cleavage Studies of Substituted β-DiketimineCopper(II) and Zinc(II) Complexes

“…Cisplatin is one of the most potent antitumour drugs available for the therapeutic management of solid tumours, overian, lung, head, neck, and bladder cancers, etc. Despite wide application as a chemotherapeutic agent, cisplatin exhibits severe side effects, such as nephrotoxicity, neurotoxicity, ototoxicity, nausea, and emetogenicity, etc., which limit possibilities for gaining therapeutic benefits from dose intensification [5,6]. Thus, scientists are now engaged to explore the transition metal based complexes and other metal based complexes.…”