Platinum(II) and palladium(II) complexes with dithiocarbamates and amines: synthesis, characterization and cell assay

Faraglia, G.; Fregona, Dolores; Sitran, S.; Giovagnini, Lorena; Marzano, Cristina; Baccichetti, F.; Casellato, U.; Graziani, R.

doi:10.1016/s0162-0134(00)00133-1

Cited by 120 publications

(24 citation statements)

References 33 publications

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“…A series of Pd(II) complexes with tertbutylsarcosinedithiocarbamate [76], ethylsarcosinedithiocarbamate and 2-/3-picoline [77], dithiocarbamates and various amines [78] were developed as antitumor agents with low nephrotoxicity. Thermogravimetric analysis was used for the characterization of these compounds.…”

Section: Metal Complexes Of Sulfur Compoundsmentioning

confidence: 99%

Thermal Analysis of Sulfur and Selenium Compounds with Multiple Applications, Including Anticancer Drugs

Plano¹,

Palop²,

Sanmartín³

2013

Applications of Calorimetry in a Wide Context - Differential Scanning Calorimetry, Isothermal Titration Calorimetry and Microca

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Section: Metal Complexes Of Sulfur Compoundsmentioning

confidence: 99%

Thermal Analysis of Sulfur and Selenium Compounds with Multiple Applications, Including Anticancer Drugs

Plano¹,

Palop²,

Sanmartín³

2013

Applications of Calorimetry in a Wide Context - Differential Scanning Calorimetry, Isothermal Titration Calorimetry and Microca

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“…[Pd(ESDT)Cl] n was previously examined for its cytotoxic properties in human leukaemia and adenocarcinoma cell lines (Faraglia et al 2001); it exhibited a significant cytotoxic effect very similar to that of cisplatin.…”

Section: Biological Assaymentioning

confidence: 99%

Synthesis of a palladium(II)-dithiocarbamate complex: biological assay and nephrotoxicity in rats

Trevisan

Marzano

Cristofori

et al. 2002

Archives of Toxicology

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A new palladium(II)-dithiocarbamate complex, [Pd(ESDT)Cl](n), was synthesised and its chemical characteristics are discussed. This complex was examined for its cytotoxic properties in human tumour cell lines; for comparison, the cytotoxicity of cisplatin was evaluated under the same experimental conditions. In particular, Pd(II)-complex cytotoxicity on ovarian carcinoma C13 cells, resistant to cisplatin, showed that there seemed to be no cross-resistance between [Pd(ESDT)Cl](n) and cisplatin. The effects on the kidney were also studied. Biochemical investigation on urinary parameters showed that the effects after a single injection are similar to those of cisplatin, with an increase of urinary proteins and enzyme excretion in urine, and a significant decrease of glutamine synthetase activity in the renal tissue. In addition, the Pd(II)-complex caused a significant decrease of p-aminohippuric acid uptake in renal cortical slices relative to cisplatin. On the other hand, histopathological findings showed that the effects of the Pd(II)-complex are more severe and diffuse than the damage caused by cisplatin. Biochemical and histopathological findings show that the Pd(II)-complex affects the pars recta and pars convoluta, in contrast to cisplatin, which only affects the pars recta.

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“…Thiosemicarbazones having ONS coordinating sites are important in coordination chemistry due to their strong bonding ability with transition metals (Alomar, Khan, Allain, & Bouet, ; Rayati, Sadeghzadeh, & Khavasi, ; Siddiki et al, ; Vieites et al, ). Researchers have focused on Pt(II) and Pd(II) complexes containing N and S donors due to metal based drugs exhibiting significant anticancer activity with lower toxicity and adverse effects (Faraglia et al, ; Salam, Affan, Arafat, Saha, & Nasrin, ).…”

Section: Introductionmentioning

confidence: 99%

“…Pd(II) complexes containing N and S donors due to metal based drugs exhibiting significant anticancer activity with lower toxicity and adverse effects (Faraglia et al, 2001;Salam, Affan, Arafat, Saha, & Nasrin, 2013).…”

mentioning

confidence: 99%

Schiff base‐nickel, palladium, and platinum complexes derived from N‐cyclohexyl hydrazine carbothioamide and 3‐hydroxy‐4‐methoxybenzaldehyde: Selective antiproliferative and proapoptotic effects against colorectal carcinoma

Arafath

Al‐Suede

Adam

et al. 2019

Drug Development Research

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The bidentate N‐cyclohexyl‐2‐(3‐hydroxy‐4‐methoxybenzylidene)hydrazine‐1‐carbothioamide Schiff base ligand (HL) was coordinated to divalent nickel, palladium and platinum ions to form square planar complexes. The nickel and palladium complexes, [NiL2], [PdL2] form square planar complexes with 2:1 ligand to metal ratio. The platinum complex, [PtL(dmso)Cl] formed a square planar complex with 1:1 ligand to metal ratio. Platinum undergoes in situ reaction with DMSO before complexing with the ligand in solution. The cytotoxicity of HL, [NiL2], [PdL2], and [PtL(dmso)Cl] were evaluated against human colon cancer cell line (HCT‐116), human cervical cancer (Hela) cell line, melanoma (B16F10) cells, and human normal endothelial cell lines (Eahy926) by MTT assay. The [NiL2] complex displayed selective cytotoxic effect against the HCT 116 cancer cell line with IC50 of 7.9 ± 0.2 μM. However, HL, [PdL2], and [PtL(dmso)Cl] only exhibited moderate cytotoxic activity with IC50 = 75.9 ± 2.4, 100.0 ± 1.8, and 101.0 ± 3.6 μM, respectively. The potent cytotoxicity of [NiL2] was characterized using Hoechst and Rhodamine assays. The nickel complex, [NiL2], caused remarkable nuclear condensation and reduction in mitochondrial membrane potential. In addition, molecular docking studies confirms that [NiL2] possesses significant binding efficiency with Tyrosine kinase. Altogether, the results revealed that [NiL2] exhibits cytotoxicity against the cancer cells via Tyrosine kinase‐induced proapoptosis pathway. This study demonstrates that the [NiL2] complex could be a promising therapeutic agent against colorectal carcinoma.

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Platinum(II) and palladium(II) complexes with dithiocarbamates and amines: synthesis, characterization and cell assay

Cited by 120 publications

References 33 publications

Thermal Analysis of Sulfur and Selenium Compounds with Multiple Applications, Including Anticancer Drugs

Thermal Analysis of Sulfur and Selenium Compounds with Multiple Applications, Including Anticancer Drugs

Synthesis of a palladium(II)-dithiocarbamate complex: biological assay and nephrotoxicity in rats

Schiff base‐nickel, palladium, and platinum complexes derived from N‐cyclohexyl hydrazine carbothioamide and 3‐hydroxy‐4‐methoxybenzaldehyde: Selective antiproliferative and proapoptotic effects against colorectal carcinoma

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