Platinum nanoparticle is a useful scavenger of superoxide anion and hydrogen peroxide

Kajita, Masashi; Hikosaka, Keisuke; Iitsuka, Mayumi; Kanayama, Atsuhiro; Toshima, Naoki; Miyamoto, Yusei

doi:10.1080/10715760601169679

Cited by 277 publications

(227 citation statements)

References 38 publications

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“…Antioxidant therapy is therefore considered an effective medical treatment for aging. It has been shown that nano-Pt can function as a strong, stable reducing catalyst that efficiently quenches ROS (16). Since the use of platinum as a food additive has been approved, commercial products supplemented with nano-Pt have been marketed in Japan as antioxidants (17).…”

Section: Discussionmentioning

confidence: 99%

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Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells

et al. 2011

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Abstract.Recent research has shown that platinum nanoparticles (nano-Pt) efficiently quench reactive oxygen species (ROS) as a reducing catalyst. ROS have been suggested to regulate receptor activator of NF-κB ligand (RANKL)-stimulated osteoclast differentiation. In the present study, we examined the direct effects of platinum nano-Pt on RANKL-induced osteoclast differentiation of murine pre-osteoclastic RAW 264.7 cells. The effect of the nano-Pt on the number of osteoclasts was measured and their effect on the mRNA expression for osteoclast differentiation was assayed using real-time PCR. Nano-Pt appeared to have a ROS-scavenging activity. Nano-Pt decreased the number of osteoclasts (2+ nuclei) and large osteoclasts (8+ nuclei) in a dose-dependent manner without affecting cell viability. In addition, this agent significantly blocked RANKL-induced mRNA expression of osteoclastic differentiation genes such as c-fms, NFATc1, NFATc2, and DC-STAMP as well as that of osteoclast-specific marker genes including MMP-9, Cath-K, CLC7, ATP6i, CTR, and TRAP. Although nano-Pt attenuated expression of the ROS-producing NOXfamily oxidases, Nox1 and Nox4, they up-regulated expression of Nox2, the major Nox enzyme in macrophages. These findings suggest that the nano-Pt inhibit RANKL-stimulated osteoclast differentiation via their ROS scavenging property. The use of nano-Pt as scavengers of ROS that is generated by RANKL may be a novel and innovative therapy for bone diseases.

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Section: Discussionmentioning

confidence: 99%

“…Platinum nanoparticles (nano-Pt) have attracted attention in recent years due to the fact that they have been shown to scavenge ROS persistently and catalytically (16). Nano-Pt are colloids of nano-sized particles of platinum, which are added to health foods or cosmetics due to their antioxidation and anti-aging properties (17).…”

Section: Introductionmentioning

confidence: 99%

Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells

et al. 2011

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“…The dismutation catalysis takes place by making use of the Os VIII =Os VII redox couple: Os VIII is reduced by superoxide with a bimolecular rate constant of k ¼ 2.6Â10 9 M À1 s À1 , and the resulting Os VII is oxidized back to Os VIII by superoxide, with a bimolecular rate constant of 1.0Â10 9 M À1 s À1 . Finally, the potential of Pt nanoparticles as SOD mimics has been reported in extending the life span of Caenorhabditis elegans (168,173). The effect at 0.5 mM only, but lack of it at 0.1 and 1 mM concentrations, raises concerns.…”

Section: Other Compoundsmentioning

confidence: 99%

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

Batinić‐Haberle

Rebouças

Spasojević

2010

Antioxidants & Redox Signaling

470

689

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Oxidative stress has become widely viewed as an underlying condition in a number of diseases, such as ischemia-reperfusion disorders, central nervous system disorders, cardiovascular conditions, cancer, and diabetes. Thus, natural and synthetic antioxidants have been actively sought. Superoxide dismutase is a first line of defense against oxidative stress under physiological and pathological conditions. Therefore, the development of therapeutics aimed at mimicking superoxide dismutase was a natural maneuver. Metalloporphyrins, as well as Mn cyclic polyamines, Mn salen derivatives and nitroxides were all originally developed as SOD mimics. The same thermodynamic and electrostatic properties that make them potent SOD mimics may allow them to reduce other reactive species such as peroxynitrite, peroxynitrite-derived CO 3 _ À , peroxyl radical, and less efficiently H 2 O 2 . By doing so SOD mimics can decrease both primary and secondary oxidative events, the latter arising from the inhibition of cellular transcriptional activity. To better judge the therapeutic potential and the advantage of one over the other type of compound, comparative studies of different classes of drugs in the same cellular and=or animal models are needed. We here provide a comprehensive overview of the chemical properties and some in vivo effects observed with various classes of compounds with a special emphasis on porphyrin-based compounds. Antioxid. Redox Signal. 13, 877-918.

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“…Recent studies have demonstrated that metal nanoparticles are potential antioxidants. Bimetallic nanoparticles consisting of gold and platinum are effective in quenching reactive oxygen species (ROS), including hydrogen peroxide (H 2 O 2 ) and the superoxide anion radical (O 2 À ), in a dose-dependent manner, 4) and gold nanoparticles enhance the antioxidant activity of vitamin E. 5) In addition nanoparticles of gold and platinum have been found to catalyze oxidation of NADH to NAD. 6,7) ROS have been implicated in bone metabolism.…”

Section: Gold Nanoparticles Inhibited the Receptor Activator Of Nuclementioning

confidence: 99%

Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

Sul¹,

Kim²,

Kyung³

et al. 2010

Bioscience, Biotechnology, and Biochemistry

105

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Platinum nanoparticle is a useful scavenger of superoxide anion and hydrogen peroxide

Cited by 277 publications

References 38 publications

Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells

Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

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