Platycodin D Impairs the Oncogenic Phenotypes of Esophageal Squamous Cell Carcinoma Cells by Elevating microRNA-4319

Abstract

To probe the action of platycodin D in the oncogenic phenotypes of esophageal squamous cell carcinoma cells and its possible mechanism. Esophageal squamous cell carcinoma cell line EC9706 was exposed to different doses of platycodin D (2.5, 5 or 10 μmol/l). Untreated cells were adopted as control group. After indicated transfection, functional analyses were carried out. The proliferation, migration and invasion of EC9706 cells were dose-dependently decreased by platycodin D. Moreover, platycodin D treatment dose-dependently increased microRNA-4319 levels in cells. MicroRNA-4319 rise impaired EC9706 cell proliferation, invasiveness and migration. Besides that, the inhibition of microRNA-4319 abolished the action of platycodin D in EC9706 cells. Platycodin D could impair cell proliferation, migration and invasion abilities in esophageal squamous cell carcinoma through elevating microRNA-4319.