PLCE1 rs2274223 Polymorphism and Susceptibility to Esophageal Cancer: a Meta-analysis

Abstract

Purpose: To investigate and study the relationship between the PLCE1 rs2274223 gene polymorphism and susceptibility to esophageal cancer by meta-analysis. Materials and Methods: The literature was searched in Wanfang, CNKI, PubMed, CBM, Web of Science, MEDLINE, EMBASE, Springer, Elsevier and Cochrane databases from the date of January 1 st 2004 to April 1 st 2014 to collect case-control studies on the PLCE1 polymorphism and susceptibility to esophageal cancer. For the population genotype distributions of both esophagus cancer and control groups, their odds ratios (ORs) and 95% confidence intervals (CIs) were taken as effect indexes. Disqualified studies were excluded. Odds ratios of PLCE1 rs2274223 genotype distributions in the group of patients with esophageal cancer and the group of healthy control were calculated. The metaanalysis software, RevMan5.0, was applied for heterogeneity test, pooled OR and 95% confidence intervals. Sensitivity analysis and publication bias were also explored. Results: A total of twelve case-control studies were included, covering a total of 9, 912 esophageal cancer cases and 13, 023 controls were included. The pooled odds ratio of PLCE1 rs2274223 genotype GA vs AA was 1.29 (95%CI=1.17~1.43), p<0.01, GG vs AA was 1.65 (95%CI=1.32~2.05), p<0.01, GG/GA vs AA was 1.30 (95%CI=1.16~1.46), p<0.01 and GG vs GA/AA was 1.48 (95%CI=1.22~1.80), p<0.01. The PLCE1 rs2274223 polymorphism was thus associated with risk of esophageal cancer in all genetic models. In the stratified analysis by ethnicity, and source of controls, no significantly increased risk was observed for white persons. There was no obvious publication bias detected. Conclusions: This meta-analysis showed there was a significantly association between PLCE1 rs2274223 polymorphism and esophageal cancer in yellow race populations. Due to some minor limitations, our findings should be confirmed in further studies.

Single Nucleotide Polymorphisms in PLCE1 for Cancer Risk of Different Types: A Meta-Analysis

“…The above findings were consistent with those reported by Umar (58), but slightly different from the findings of Xue et al (14), which suggested that rs2274223 polymorphism was not associated with susceptibility to gastric cancer. The results based on the esophageal cancer subgroup were consistent with the results of Wang et al (59) and Guo et al (60). Moreover, the results of the stratified analysis indicated that the rs2274223 polymorphism was associated with cancer susceptibility in Asians but not in Caucasians, consistent with the findings of Umar et al (58).…”

Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta‐analysis and genome‐wide association studies

“…For 51 SNPs identified by meta‐analysis, 38 SNPs had statistically significant association with EC or ESCC susceptibility . Meta‐analysis results showed that there were 27 SNPs associated with increased EC or ESCC risk, whereas 11 SNPs decreased the risk of EC or ESCC risk.…”

PLCE1Promotes the Invasion and Migration of Esophageal Cancer Cells by Up-Regulating the PKCα/NF-κB Pathway

“…Gu, et al 14 found that PLCE1 rs2274223 could be used to predict the risk of esophageal cancer. Also, Guo, et al 15 revealed that PLCE1 rs2274223 polymorphism is associated with esophageal cancer. Study has also shown that PLCE1 regulates cell growth, proliferation, and differentiation and affects cytoskeleton change, cell movement, cell apoptosis, tumor growth and development, and other biological behaviors.…”