Pleomorphic Dermal Sarcoma: A Clinical and Histopathologic Emulator of Atypical Fibroxanthoma, but Different Biologic Behavior

Carletti, Michael; Nguyen, Daniel A.; Malouf, Peter; Ingersoll, Zachary; Hosler, Gregory A.; Weis, Stephen E.

doi:10.36518/2689-0216.1334

Cited by 4 publications

(1 citation statement)

References 14 publications

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“… 2 , 3 , 12 Notably, AFX/PDS are diagnoses of exclusion, requiring broad lineage-specific immunohistochemical analysis to exclude other malignant, poorly differentiated tumors such as squamous cell cancer and melanoma, among others. 13 This underscores the importance of IHC in supplementing diagnosis, especially in distinguishing PDS/AFX from other spindle cell lesions. However, currently, there are no reliable discriminatory immunomarkers that distinguish AFX from PDS.…”

Section: Discussionmentioning

confidence: 92%

Pleomorphic Dermal Sarcoma With Metastasis to the Lung: A Case Report

Shafi

Bechtel

Plaza

2023

The American Journal of Dermatopathology

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Atypical fibroxanthoma and pleomorphic dermal sarcoma (PDS) are dermal malignant mesenchymal tumors that lie at the ends of the same disease spectrum. Clinically indistinguishable from atypical fibroxanthoma, PDS has a more aggressive course with significantly higher rate of local recurrence and metastases. Histological findings that favor a PDS include subcutaneous invasion, tumor necrosis, lymphovascular invasion, and/or perineural infiltration. Herein, we report a case of PDS with metastasis to the lung. Our report highlights the risk of local recurrence and metastatic spread in this cutaneous tumor and the importance of distinguishing this entity from its less aggressive counterpart.

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