Pleural Cavity Irrigation with Taurolidine during Lung Transplant May Reduce the Risk of Post-Operative Pleural Infection.

Whale, CI; McMorrow, Jason P.; Higton, A.; Fernandez, N Curbelos; Lawrence, Scott L.; Jary, C. L.; Chambers, Daniel C.; Gabbay, Eli; Musk, M.

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4611

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“…The use of Taurolidine to treat surgical infection in the operation room was first described in some anecdotal reports in the 1980s. Subsequently, Taurolidine has been most commonly used in locking solutions to prevent catheter-related bloodstream infection in fragile patients [4][5][6]. As far as we are aware, Taurolidine has not been used to treat a VAD driveline infection before.…”

Section: Discussionmentioning

confidence: 99%

Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine

Weichsel

Baldauf

Bonnemeier

et al. 2022

JCDD

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Ventricular assist devices (VADs) are used to provide mechanical circulatory support to patients with end-stage heart failure. The driveline connecting the external power source to the pump(s) of the intra-corporal VAD breaches the protective skin barrier and provides a track for microbes to invade the interior of the patient’s body. Driveline infection constitutes a major and potentially fatal vulnerability of VAD therapy. Driveline infection cannot traditionally be salvaged and requires the extraction of the entire VAD system. We report here the successful eradication of a VAD driveline infection with a taurolidine-containing antimicrobial solution used for preventing the infection of cardiac implantable electronic devices. If replicated in more cases, the novel treatment concept described here may provide a valuable alternative management strategy of salvage rather than explantation for VAD driveline infection.

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Section: Discussionmentioning

confidence: 99%