2013
DOI: 10.1016/j.clinbiochem.2012.11.024
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Pleural fluid protein is inversely correlated with age in uncomplicated parapneumonic pleural effusions

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Cited by 7 publications
(5 citation statements)
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“…found that in patients with pleural effusion near pneumonia, anaerobic glycolysis metabolism was enhanced, lactic acid and butyric acid were increased, and the increased expression of hypoxanthine may be related to the formation of fibrin in the pleural cavity [ 31 ]. In addition, the pleural effusion around simple pneumonia and complex pneumonia can be distinguished by protein spectrum analysis, and the people who need active treatment or even surgical treatment can be predicted [ 32 , 33 ]. Through proteomics, Wu et al .…”
Section: Discussionmentioning
confidence: 99%
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“…found that in patients with pleural effusion near pneumonia, anaerobic glycolysis metabolism was enhanced, lactic acid and butyric acid were increased, and the increased expression of hypoxanthine may be related to the formation of fibrin in the pleural cavity [ 31 ]. In addition, the pleural effusion around simple pneumonia and complex pneumonia can be distinguished by protein spectrum analysis, and the people who need active treatment or even surgical treatment can be predicted [ 32 , 33 ]. Through proteomics, Wu et al .…”
Section: Discussionmentioning
confidence: 99%
“…This study also has some limitations, such as a small sample size and insufficient representativeness. And into the group of patients with standard need to be further refinement, such as pneumonia side pleural effusion patients of different ages there may be some difference between protein content [ 33 ], so in a follow-up study, we need to further increase the sample size, at the same time reduce the influence of some confounding factors, and look forward to the future we can have better results.…”
Section: Discussionmentioning
confidence: 99%
“…This is a novel finding and may relate to previous findings from our group showing that PF protein levels in a different clinical entity, complicated parapneumonic effusions, are inversely correlated with age. 34 As the alterations of PF physiology and pathophysiology with respect to age are scarcely studied this finding requires further investigation. Still its clinical value relates to the fact that in biomarker discovery age may have to be taken into account.…”
Section: Discussionmentioning
confidence: 99%
“…pneumonia, lung cancer, malignant pleural mesothelioma (MPM), pulmonary embolism] pleural effusions occur (excess accumulation of pleural fluid in the pleural cavity) [4]. Depending on the underlying pathology, protein, glucose, lactate dehydrogenase and pH pleural fluid levels vary; as is the case for cytokines and growth factors that are produced locally either by pleural mesothelial cells or by leucocytes [2][3][4][5][6][7][8]. Thus, the pleural mesothelial cells in pathophysiological conditions can encounter various biochemical environments that may influence their functions e.g.…”
Section: Introductionmentioning
confidence: 99%