Pleurotus ferulae water extract enhances the maturation and function of murine bone marrow-derived dendritic cells through TLR4 signaling pathway

Li, Jinyao; Wang, Xinhui; Wang, Weilan; Luo, Jiaojiao; Aipire, Adila; Zhang, Fuchun

doi:10.1016/j.vaccine.2015.02.063

Cited by 30 publications

(25 citation statements)

References 45 publications

(82 reference statements)

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“…Many studies including ours have shown that herbal medicine extracts or its components can enhance antitumor immune responses through promoting the activation status of DCs28293233. In this study, we observed that GUWE improved the maturation and cytokine production of DCs, especially IL-12 production.…”

Section: Discussionsupporting

confidence: 54%

“…Our previous study showed that Pleurotus ferulae water extract could promote DC maturation via TLR4 signaling pathway28. Here, we also investigated whether GUWE promotes DC maturation via TLR4 signaling pathway.…”

Section: Resultsmentioning

confidence: 88%

“…Our previous studies showed that PFWE could enhance the maturation and function of DCs, and the antitumor efficacy of HPV DC-based vaccine2829. Here, we prepared the HPV DC-based vaccine as the following: GUWE treated DCs were pulsed with HPV-16 E6/E7 peptides (GUWE-HPV-DCs).…”

Section: Resultsmentioning

confidence: 99%

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Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine

Aipire

Yuan

et al. 2017

Sci Rep

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Licorice has been used as herbal medicine and natural sweetener. Here, we prepared Glycyrrhiza uralensis water extract (GUWE) and investigated the effect of GUWE on the maturation and function of dendritic cells (DCs) and its adjuvant effect on DC-based vaccine. We observed that GUWE dose-dependently promoted DC maturation and cytokine secretion through TLR4 signaling pathway. The capacity of DC to stimulate allogenic splenocyte proliferation was also enhanced by GUWE treatment. Compared with control group, GUWE treated DCs pulsed with human papillomavirus (HPV)-16 E6/E7 peptides significantly inhibited the tumor growth in both early and late therapeutic groups. In early therapeutic group, the frequencies of induced regulatory T cells (iTregs: CD4+CD25−Fopx3+) and CD4+ and CD8+ T cells were significantly decreased and increased, respectively. HPV-16-specific CD8+ T cell responses were significantly induced and negatively correlated with iTreg frequencies and tumor weight. These results indicated the immunoregulatory activities of licorice.

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Section: Discussionsupporting

confidence: 54%

Section: Resultsmentioning

confidence: 88%

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Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine

Aipire

Yuan

et al. 2017

Sci Rep

Self Cite

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“…B-chain of Korean mistletoe lectin could promote the maturation of DCs to increase the expressions of co-stimulatory molecules (CD40, CD80, CD86), MHC II and the secretions of cytokines , which is mediated by TLR4 . Our study showed that Pleurotus ferulae water extract increased the expression of CD40, CD80, CD86 and MHC II on murine bone marrow-derived DCs (BM-DCs) and the production of IL-6, IL-12 and TNF-α through TLR4 signaling pathway, and enhanced the proliferation of allogenic CD8 þ T cells and the capacity of antigen presenting to autologous CD8 þ T cells (Li et al, 2015).…”

Section: Introductionmentioning

confidence: 66%

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

Zhang

2015

Journal of Ethnopharmacology

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“…Likewise, Li et al . showed that Pleurotus ferulae , an edible mushroom with both substantial nutritional value and pharmacological properties [62], enhanced the function and maturation of murine bone marrow-derived dendritic cells through TLR4 signaling [63]. Shibata et al .…”

Section: Tlr Dysregulationmentioning

confidence: 99%

Modulation of Toll-like receptor signaling in innate immunity by natural products

Chen

2016

International Immunopharmacology

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For centuries, natural products and their derivatives have provided a rich source of compounds for the development of new immunotherapies in the treatment of human disease. Many of these compounds are currently undergoing clinical trials, particularly as anti-oxidative, anti-microbial, and anti-cancer agents. However, the function and mechanism of natural products in how they interact with our immune system has yet to be extensively explored. Natural immune modulators may provide the key to control and ultimately defeat disorders affecting the immune system. They can either up- or down-regulate the immune response with few adverse side effects. In this review, we summarize the recent advancements made in utilizing natural products for immunomodulation and their important molecular targets, members of the Toll-like receptor (TLR) family, in the innate immune system.

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Pleurotus ferulae water extract enhances the maturation and function of murine bone marrow-derived dendritic cells through TLR4 signaling pathway

Cited by 30 publications

References 45 publications

Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine

Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

Modulation of Toll-like receptor signaling in innate immunity by natural products

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