Plexiform schwannoma: a clinicopathologic overview with emphasis on the head and neck region

Berg, Jena C.; Scheithauer, Bernd W.; Spinner, Robert J.; Allen, Carl M.; Koutlas, Ioannis G.

doi:10.1016/j.humpath.2007.10.029

Cited by 118 publications

(128 citation statements)

References 9 publications

Supporting

Mentioning

109

Contrasting

Unclassified

Order By: Relevance

“…Plexiform (multinodular) schwannoma is a distinct variant of schwannoma. Representing approximately 4% of all schwannomas, approximately one-quarter arise in the head and neck region [41] and 5% each in the setting of neurofibromatosis type II and schwannomatosis. Histologically, they feature Antoni A and B patterns, Verocay bodies, ectatic and hyalinized vessels, and they are completely surrounded by a perineurial capsule.…”

Section: Differential Diagnosismentioning

confidence: 99%

Palisaded Encapsulated (“Solitary Circumscribed”) Neuroma of the Oral Cavity: A Review of 55 Cases

Koutlas

Scheithauer

2010

Head and Neck Pathol

Self Cite

View full text Add to dashboard Cite

We describe the clinicopathologic characteristics of 55 oral palisaded encapsulated (solitary circumscribed) neuromas (PEN/SCN). Fifty-five cases of PEN/SCN in 54 patients were reviewed. Lesions were categorized according to their histologic pattern, partial or complete encapsulation, presence of Verocay bodies and presence of a parent peripheral nerve. In 13 selected cases immunohistochemical evaluation for neuronal markers (S-100, GFAP, NFP, EMA) was performed. When immunoreaction with EMA was weak, claudin-1 and glut-1 stains were utilized. Thirty-eight patients were men and 16 were women. Mean patient age was 48 years (SD: +/-14). The vast majority involved the masticatory (palate and gingiva) mucosa (76.4%) followed by the labial mucosa, the tongue and buccal mucosa. Recurrence was recorded in only one case. Histologically, 34 lesions had a lobular pattern, 10 were plexiform, 7 fungating and 4 multilobular. Stroma was limited, but focal myxoid changes were seen at the periphery of the lobules. Only one predominantly myxoid lesion was encountered. The number of intralesional axons varied, but the ratio of Schwann cells to axons was generally less than 1:2. Most lesions (89%) were only partially surrounded by perineurium. Tumor cells were S-100 positive and GFAP negative. The parent nerve was identified in 50% of the cases. Overlying epithelium was generally atrophic. Peritumoral connective tissue was generally unremarkable, but chronic inflammation was present in five cases. PEN/SCN is a relatively common peripheral nerve sheath tumor. Generally, its diagnosis is simple. GFAP may be of help to distinguish PEN/SCN from other peripheral nerve sheath tumors (schwannoma, neurofibroma, traumatic neuroma) in cases where histomorphologic features may be confusing. Finally, pathologists should be aware of the occurrence of plexiform and multilobular PEN/SCN variants, to avoid misinterpretation as plexiform neurofibroma or schwannoma.

show abstract

Section: Differential Diagnosismentioning

confidence: 99%

Palisaded Encapsulated (“Solitary Circumscribed”) Neuroma of the Oral Cavity: A Review of 55 Cases

Koutlas

Scheithauer

2010

Head and Neck Pathol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Conventional and plexiform schwannomas often arise in superficial soft tissues, particularly of the head and neck region, which is rich in superficially situated peripheral nerves [17].…”

Section: Discussionmentioning

confidence: 99%

“…The degenerative changes frequently seen in large longlasting lesions include hemorrhage, infarction, cyst formation, and dystrophic calcification [17].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic analysis of 7 cases of oral schwannoma and review of the literature

Santos

Freitas

Pinto

et al. 2010

Annals of Diagnostic Pathology

View full text Add to dashboard Cite

Schwannomas, also known as neurilemmomas, are uncommon neoplasms apparently derived from Schwann cells. The growth of these tumors causes displacement and compression of the nerve of origin. Schwannomas are usually solitary lesions but can be multiple when associated with neurofibromatosis. Anti-S100 protein is the most widely used antibody for the identification of this neoplasm. Surgical excision is the treatment of choice for schwannomas, with few and controversial reports of recurrence or malignant transformation. The present article reports 7 additional cases of oral schwannoma, and the literature is reviewed regarding clinicopathologic features, immunohistochemical findings, differential diagnosis, and therapeutic management of this benign neural tumor. Crown

show abstract

“…Most plexiform schwannomas are solitary, sporadically occurring tumors. Plexiform schwannomas typically arise from superficial tissues (79%), occurring most commonly in the head and neck region (23%) and in 15% of cutaneous schwannomas [2]. In the male genital neoplasms, there have been two cases of benign intratesticular schwannoma reported in the published literature, including one report of an unusual plexiform variant growth of testicular schwannoma [3].…”

mentioning

confidence: 99%

“…The rate of local recurrence is extremely low after com plete resection with free surgical margins [10]. Recurrence may happen when excised incompletely [2]. Local resection is the treatment of choice for penile schwannomas and regular follow-up is suggested.…”

mentioning

confidence: 99%

An infrequent plexiform variant of schwannoma of the glans penis: a rare finding

Lin¹,

Wu²,

Lin³

et al. 2010

Asian J Androl

View full text Add to dashboard Cite

Plexiform schwannoma: a clinicopathologic overview with emphasis on the head and neck region

Cited by 118 publications

References 9 publications

Palisaded Encapsulated (“Solitary Circumscribed”) Neuroma of the Oral Cavity: A Review of 55 Cases

Palisaded Encapsulated (“Solitary Circumscribed”) Neuroma of the Oral Cavity: A Review of 55 Cases

Clinicopathologic analysis of 7 cases of oral schwannoma and review of the literature

An infrequent plexiform variant of schwannoma of the glans penis: a rare finding

Contact Info

Product

Resources

About