2024
DOI: 10.3389/fimmu.2023.1297354
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Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins

Svetlana P. Chapoval,
Hongjuan Gao,
Rachel Fanaroff
et al.

Abstract: We investigated the effect of global Plexin B1 deficiency on allergic airway responses to house dust mite (HDM) or ovalbumin (OVA). In the HDM model, there were higher Th2 cytokine levels in the BALF of Plexin B1 knock-out (KO) mice compared to wild type (WT), and tissue inflammation and mucus production were modestly enhanced. In the OVA model, Plexin B1 deficiency led to increases in lung inflammation, mucus production, and lung Th2 cytokines accompanied by dysregulated mucin gene expression without affectin… Show more

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