Plexin D1: New Potential Biomarker for Cervical Cancer

Abstract

To explore possible role of Plexin D1 in cancer angiogenesis with special focus on cervical cancer. Twelve various normal tissues, 12 various tumor samples, and 59 different stages of cervical cancer samples on tissue microarrays were examined for the expression of Plexin D1. The findings of our study clearly indicate that Plexin D1 is strongly associated with cellular differentiation in the tissues investigated, and that expression is strongly dependent on the tumor histotype. In some tumor subtypes, the protein was detected at several-fold higher levels than was found in the corresponding normal tissues, while in others, expression was similar to normal tissues. Most significantly, strong expression was detected in the endothelial cells of the cervical cancer samples, yet no expression was seen in endothelial cells of normal cervical tissues, which suggests a potential role of Plexin D1 in cervical cancer-associated angiogenesis.Regarding the implications of Plexin D1 and its associations with cancer angiogenesis, it might be a potential cervical cancer biomarker if further studies confirm the present preliminary findings.

The phenotypic spectrum of Xia‐Gibbs syndrome

“…REV3L is the catalytic subunit of polymerase zeta and is implicated in genome stability and DNA translesion repair (Gan et al, ) and it is therefore conceivable that AHDC1 mutations may interfere with DNA repair. Previous work has shown the interaction of AHDC1 with Tax Interaction Protein 1 which was proposed to occur in vivo under DNA damaging conditions (Shalaby, Hampson, Oliver, & Hampson, ), supporting this model.…”

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

“…In addition to their known correlation with PDA survival, plexins also play a role in the development and progression of other cancer types. Specifically, PlxnD1 abundance is associated with high-grade primary and metastatic melanomas (8) as well as poorly differentiated cervical carcinoma tissues (9). By serving as a cellular receptor and signaling transducer for the class 3 semaphorin Sema3E, PlxnD1 promotes cancer cell invasiveness in multiple human tumor types and metastatic spreading in mouse models (10).…”

Semaphorin 3E Suppresses Tumor Cell Death Triggered by the Plexin D1 Dependence Receptor in Metastatic Breast Cancers

“…Abnormal expression levels of semaphorins and their receptors are commonly observed in cancers. For example, expression of the Plexin D1 receptor has been reported in tumor vasculature and in malignant cells in a wide range of human cancer types (Casazza et al, 2010;Roodink et al, 2005Roodink et al, , 2009Shalaby et al, 2012;Tseng et al, 2011). Expression levels of its Sema3E ligand appear to be positively correlated with increased metastatic disease in ovarian, melanoma, and colon cancers and with poor patient survival in colorectal and pancreatic cancers (Biankin et al, 2012;Casazza et al, 2010;Tseng et al, 2011).…”