PLGA-based drug delivery system for combined therapy of cancer: research progress

Abstract

In recent years, PLGA micro/nano particle drug delivery systems has been widely used in cancer treatment. According to the unique properties of PLGA, carriers of various structures are designed to keep the function of drugs or bioactive substances, ensure the effective load of molecules and improve the bioavailability of drugs in diseased parts. PLGA is one of the earliest and most commonly used biodegradable materials. It is often used for functional modification with other polymers (such as polyethylene glycol and chitosan) or other molecules (such as aptamers and ligands) to deliver various small molecule drugs (such as DOX and DTX) and bioactive macromolecules (such as proteins and nucleic acids) to improve targeting, controlled release and therapeutic properties. In this paper, the preparation methods, physical and chemical properties and medical applications of PLGA micro/nano particles are discussed. We focused on the recent research progress of the PLGA-based drug carrier system in tumor combination therapy.

Delivery process and effective design of vectors for cancer therapy

“…[3][4][5] In addition, a key reason for the failure of chemotherapeutic drugs in cancer treatment is mainly the multidrug resistance of cancer. [6][7][8] For a long time, researchers have been exploring and developing a variety of therapeutic methods, and drug vectors are an important aspect of them 9 , because they can effectively prevent drug degradation, deliver drugs to pathological sites, reduce toxic side effects, and improve therapeutic effects. There is a continuous need to meet current cancer treatment requirements by developing new drug delivery systems.…”

Progress in the drug encapsulation of poly(lactic-co-glycolic acid) and folate-decorated poly(ethylene glycol)–poly(lactic-co-glycolic acid) conjugates for selective cancer treatment

“…Several comprehensive reviews have discussed the use of PLGA as a drug delivery system for cancer therapy. [10][11][12][13] Here, this current review focuses on giving an overview of the recent progress in PLGA-based conjugated systems for the treatment of different cancers. The drug encapsulation studies of PLGA and FA-PEG-PLGA conjugates have also been discussed based on their chemistries, functionalized copolymers, preparation methods, and the structural coordination between the drug and the conjugate.…”

Electrospun, Resorbable, Drug-Eluting, Nanofibrous Membranes Promote Healing of Allograft Tendons

“…The experimental data demonstrated that electrospun nanofibers improve and accelerate the process of healing and thus offer a promising solution to the management of wounds. Additionally, electrospun nanofiber mats possess distinct, extraordinary characteristics, including excessive surface areas, a light weight, a porous network structure, and good stiffness and tensile strength, as compared to traditional fibers [ 44 , 45 ]. The electrospinning process can also produce nanofibrous mats with various structural assemblies, including nonwoven mesh, aligned mesh, patterned mesh, etc.…”

“…The electrospinning process can also produce nanofibrous mats with various structural assemblies, including nonwoven mesh, aligned mesh, patterned mesh, etc. [ 44 , 46 , 47 , 48 ]. In our previous study, we developed doxycycline-incorporated nanofibers and investigated their influence on the repair of ruptured tendons [ 49 ].…”