PLGA-graphene quantum dot nanocomposites targeted against αvβ3 integrin receptor for sorafenib delivery in angiogenesis

Rahiminezhad, Zahra; Tamaddon, Ali‐Mohammad; Dehshahri, Ali; Borandeh, Sedigheh; Abolmaali, Samira Sadat; Najafi, Haniyeh; Azarpira, Negar

doi:10.1016/j.bioadv.2022.212851

Cited by 10 publications

(11 citation statements)

References 59 publications

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“…The band around 1570 cm −1 in βCD‐PEI‐GQD confirmed secondary amide bond formation between GQD and free amines of βCD‐PEI [51] . The fluorescence spectra (Figure 3) for both GQD and βCD‐PEI‐GQD aqueous dispersions exhibit the excitation at 440 nm that leads to emission at 526 nm, which is consistent with other studies [42,52] . Moreover, the observed peaks were sharp and intense, confirming the size uniformity and homogeneity of these two compounds.…”

Section: Resultssupporting

confidence: 86%

“…[51] The fluorescence spectra (Figure 3) for both GQD and βCD-PEI-GQD aqueous dispersions exhibit the excitation at 440 nm that leads to emission at 526 nm, which is consistent with other studies. [42,52] Moreover, the observed peaks were sharp and intense, confirming the size uniformity and homogeneity of these two compounds. Furthermore, the higher fluorescence intensity of free GQD when compared to βCD-PEI-GQD nanocarrier indicated that GQD conjugation could reduce the intrinsic fluorescence property.…”

Section: Preparation Of βCd-pei-gqd Nanocarriersupporting

confidence: 52%

“…Graphene quantum dots (GQDs) are carbon-based nanomaterial with interesting properties such as non-cytotoxicity, high photoluminescence, and high chemical stability, employed in biological imaging and tracking with two different (green and red) emission colors. [42] Thus, GQD enables the nanocarriers to be tracked efficiently without needing to label them. [43] The intrinsic fluorescence of the GQDs can be employed to discriminate transfected and non-transfected cells, while the large surface of GQD can facilitate intracellular gene delivery of microRNAs.…”

Section: Chemistryselectmentioning

confidence: 99%

“…Consequently, trackable systems are of great importance to achieve this goal. Graphene quantum dots (GQDs) are carbon‐based nanomaterial with interesting properties such as non‐cytotoxicity, high photoluminescence, and high chemical stability, employed in biological imaging and tracking with two different (green and red) emission colors [42] . Thus, GQD enables the nanocarriers to be tracked efficiently without needing to label them [43] .…”

Section: Introductionmentioning

confidence: 99%

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Graphene Quantum Dot‐PEI‐Cyclodextrin Nanocarrier for Simultaneous miR21a Delivery and Cell Imaging in Cancer Therapy

et al. 2023

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Over‐expression of miR21 plays an important role in several cancers by promoting cancer cell proliferation, migration, invasion, and metastasis. Here, we attempted to prepare a beta cyclodextrin‐polyethyleneimine‐graphene quantum dot (βCD‐PEI‐GQD) nanocarrier for cellular delivery of miR21a. For this purpose, tosylated‐βCD and GQD were conjugated to branched PEI. The product was characterized by FTIR, 1H‐NMR, and fluorescence spectroscopy. The morphology, particle size distribution, and ζ‐potential of miR21a were examined by TEM and DLS following overnight incubation with βCD‐PEI‐GQD in aqueous media. The miR21 silencing was measured by stem‐loop RT‐PCR in HepG2 human hepatoma cell line. Cellular uptake and cell toxicity assays were determined by fluorescence microscopy and Trypan blue staining method, respectively. The formation of miR21a/CD‐PEI‐GQD Nanoplex with a decreased average size of 114 nm and a ζ‐potential (+36.1 mV) lower than CD‐PEI‐GQD nanocarrier by adding miR21a was confirmed at optimum C/P ratio =8.7. RT‐PCR revealed that miR21a/βCD‐PEI‐GQD Nanoplex significantly downregulated miR21 expression levels effectively. Overall, miR21a delivery using CD‐PEI‐GQD is presented as a novel trackable nanocarrier for cancer therapy.

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Section: Resultssupporting

confidence: 86%

Section: Preparation Of βCd-pei-gqd Nanocarriersupporting

confidence: 52%

Section: Chemistryselectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Graphene Quantum Dot‐PEI‐Cyclodextrin Nanocarrier for Simultaneous miR21a Delivery and Cell Imaging in Cancer Therapy

et al. 2023

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“…The properties and chemical structure of some chemically synthesized anticancer drugs. ○ Poor solubility and bioavailability ○ Systemic toxicity ○ Rapid metabolism by dihydropyramidine dehydrogenase [11][12][13][14] Irinotecan (a topoisomerase I inhibitor) ○ Instability at physiological medium ○ Poor solubility ○ Severe side effects [15][16][17][18] Sorafenib (a multi-kinase inhibitor) ○ Poor solubility and bioavailability ○ Systemic side effects [19][20][21] 10-Hydroxycamptothecin (a member of the enzyme topoisomerase I inhibitor)…”

Section: Introductionmentioning

confidence: 99%

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Falsafi

Wang

Ashaolu

et al. 2022

Adv Funct Materials

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Cancer is the second leading cause of death throughout the world. Nature‐inspired anticancer agents (NAAs) that are a gift of nature to humanity have been extensively utilized in the alleviation/prevention of the disease due to their numerous pharmacological activities. While the oral route is an ideal and common way of drug administration, the application of NAAs through the oral pathway has been extremely limited owing to their inherent features, e.g., poor solubility, gastrointestinal (GI) instability, and low bioavailability. With the development of nano‐driven encapsulation strategies, polymeric vehicles, especially those with natural origins, have demonstrated a potent platform, which can professionally shield versatile NAAs against GI barricades and safely deliver them to the site of action. In this review, the predicament of orally delivering NAAs and the encapsulation strategy solutions based on biopolymer matrices are summarized. Proof‐of‐concept in vitro/in vivo results are also discussed for oral delivery of these agents by various biopolymer vehicles, which can be found so far from the literature. Last but not the least, the challenges and new opportunities in the field are highlighted.

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Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Das,

Roy,

Saha

2024

Biotech & Bioengineering

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The carbon‐based nanostructures have led to the development of theranostic nanoplatforms for simultaneous diagnosis and therapy due to their effective cell membrane‐penetration ability, low degree of cytotoxicity, excellent pore volume, substantial chemical stability, and reactive surface. In the last few years, extensive efforts were made to design multifunctional nanoplatform strategies based on carbon nanostructures, involving multimodal imaging, controlled drug release capabilities, sensing in vitro, efficient drug loading capacity, and therapy. Carbon and graphene quantum dots (CQDs and GQDs) were the recent entrants, contingently being assessed for drug delivery and bioimaging. With the advancements, these quantum dots have ignited remarkable research interest and are now widely evaluated for diagnosis, bioimaging, sensing, and drug delivery applications. The last decade has witnessed their remarkable electrical, optical, and biocompatible properties since their inception. It is presumed that both of them have high potential as drug carriers and would serve as the next generation of approaches to address numerous unresolved therapeutic challenges. This review examined the recent advances of CQD and GQD based drug delivery applications, challenges, and future perspectives to pave the way for further studies in the future.

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PLGA-graphene quantum dot nanocomposites targeted against αvβ3 integrin receptor for sorafenib delivery in angiogenesis

Cited by 10 publications

References 59 publications

Graphene Quantum Dot‐PEI‐Cyclodextrin Nanocarrier for Simultaneous miR21a Delivery and Cell Imaging in Cancer Therapy

Graphene Quantum Dot‐PEI‐Cyclodextrin Nanocarrier for Simultaneous miR21a Delivery and Cell Imaging in Cancer Therapy

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

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