PLGA nanoparticles as chlorhexidine-delivery carrier to resin-dentin adhesive interface

Priyadarshini, Balasankar Meera; Kakran, Mitali; Lu, Thong Beng; Handral, Harish K; Dubey, Nileshkumar; Fawzy, A.

doi:10.1016/j.dental.2017.04.015

Cited by 48 publications

(39 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We compared our results with the literature to explain our drug release kinetic. As reported in [33], we guess that the polymer-drug interaction might be responsible for the steady state of CHX release observed after several days of elution [38]. When the drug content increases, the amount of the drug not linked to the polymer could increase, and would thus be released during the first days.…”

Section: In Vitro Chx Releasementioning

confidence: 60%

Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants

et al. 2020

View full text Add to dashboard Cite

To prevent the uncontrolled development of a pathogenic biofilm around a dental implant, an antimicrobial drug-release electrospun membrane, set up between the implant and the gingival tissue, was developed by taking several technical, industrial and regulatory specifications into account. The membrane formulation is made of a blend of poly(l-lactic–co–gycolic acid) (PLGA, 85:15) and poly(l-lactic acide–co–ɛ-caprolactone) (PLC, 70:30) copolymers with chlorhexidine diacetate (CHX) complexed with β-cyclodextrin (CD). The amount of residual solvent, the mechanical properties and the drug release kinetics were tuned by the copolymers’ ratio, between 30% and 100% of PLC, and a CHX loading up to 20% w/w. The membranes were sterilized by γ-irradiation without significant property changes. The fiber′s diameter was between 600 nm and 3 µm, depending on the membrane composition and the electrospinning parameters. CHX was released in vitro over 10 days and the bacterial inhibitory concentration, 80 µg·mL−1, was reached within eight days. The optimal membrane, PGLA/PLC/CHX-CD (60%/40%/4%), exhibited a breaking strain of 50%, allowing its safe handling. This membrane and a membrane without CHX-CD were implanted subcutaneous in a rat model. The cell penetration remained low. The next step will be to increase the porosity of the membrane to improve the dynamic cell penetration and tissue remodeling.

show abstract

Section: In Vitro Chx Releasementioning

confidence: 60%

Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Chlorhexidine is still widely used in the DDS modified resin [95,96]. Nanoparticles, sphere, capsules, etc were designed as carriers.…”

Section: Dds For Secondary Cariesmentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

View full text Add to dashboard Cite

The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

show abstract

“…CHX loaded PLGA NPs in aqueous solution can penetrate and inltrate via dentinal tubules up to 10 mm depth, which have a close association with the resin tags aer binding resin inltration. 180 Gutiérrez et al assessed the impact of adding copper NPs (Cu NPs) at various concentrations into a two-step etch-andrinse (2 ER) adhesive on the anti-microbial activities (AMA), copper release (CR), degree of conversion (DC), water sorption (WS), solubility (SO), immediate (IM), ultimate tensile strength (UTS), 1 year resin dentin bond strength (mTBS), and nano-leakage (NL). The addition of Cu NPs presented AMA towards the adhesives at each concentration.…”

Section: Nano-materials For Restorationmentioning

confidence: 99%