We propose a line of research for road freight logistics that may deliver novel enterprise information system (EIS) architectures, procedures, and novel ways of applying existing technology, with the direct objective of enabling and making more efficient a variation of an existing logistic scenario, which is presented to some extent in this position paper. We argue that the enabling and support of this setting via appropriately identified, tested, and practitioner-validated EIS functions may have the effect of increasing the load factors in palletized road freight, as well as allowing mass Just-in-time (JIT) transshipment from small scale suppliers and delivery to small scale end-customers. 388 Szirbik N. and Buijs P.. Discovering the EIS Architecture that Supports Hub-and-Spoke Freight Transportation Networks Operating in a Cross Dock Mode.