Plumbagin caged silver nanoparticle stabilized collagen scaffold for wound dressing

Duraipandy, Natarajan; Lakra, Rachita; Srivatsan, Kunnavakkam Vinjimur; Usha, R.; Korrapati, Purna Sai; Kiran, Manikantan Syamala

doi:10.1039/c4tb01791a

Cited by 46 publications

(36 citation statements)

References 57 publications

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“…The use of functional analogs or conjugation with therapeutic compounds could solve such problems. Nano-biotechnological intervention has proven to be effective in increasing the physicochemical properties of molecules [36]. Nano-silver has been reported to exhibit different and enhanced physicochemical properties compared to bulk silver.…”

Section: Introductionmentioning

confidence: 99%

Effect of curcumin caged silver nanoparticle on collagen stabilization for biomedical applications

Srivatsan

Duraipandy

Begum

et al. 2015

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

Effect of curcumin caged silver nanoparticle on collagen stabilization for biomedical applications

Srivatsan

Duraipandy

Begum

et al. 2015

International Journal of Biological Macromolecules

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“…Antibacterial and pro-wound healing activities in the PBG crosslinked collagen scaffold suggest the importance of nanobiotechnology for the development of biomaterials for tissue engineering applications [88].…”

Section: Nanofibersmentioning

confidence: 99%

Silver Nanomaterials for Wound Dressing Applications

et al. 2020

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Silver nanoparticles (AgNPs) have recently become very attractive for the scientific community due to their broad spectrum of applications in the biomedical field. The main advantages of AgNPs include a simple method of synthesis, a simple way to change their morphology and high surface area to volume ratio. Much research has been carried out over the years to evaluate their possible effectivity against microbial organisms. The most important factors which influence the effectivity of AgNPs against microorganisms are the method of their preparation and the type of application. When incorporated into fabric wound dressings and other textiles, AgNPs have shown significant antibacterial activity against both Gram-positive and Gram-negative bacteria and inhibited biofilm formation. In this review, the different routes of synthesizing AgNPs with controlled size and geometry including chemical, green, irradiation and thermal synthesis, as well as the different types of application of AgNPs for wound dressings such as membrane immobilization, topical application, preparation of nanofibers and hydrogels, and the mechanism behind their antimicrobial activity, have been discussed elaborately.

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“…The presence of high surface properties and surface area at nanoscale level makes the nanomaterials a preferred substrate for conjugating biomolecules . Conjugation of the therapeutic molecule with nanoparticle does not alter essential therapeutic properties of conjugates rather it brings in the cumulative physicochemical properties of both the bioactive molecule as well as the nanoparticles to which it is conjugated …”

Section: Introductionmentioning

confidence: 99%

Targeting Pyruvate Kinase M2, β Catenin Signaling by Juglone Silver Nano Framework for Selective Cancer Cell Death

et al. 2018

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The modern biomedical nanotechnology necessitates functionalized nanoparticles for targeted action on diseased cells with excellent physico chemical properties. The present study revealed the potential of fabricating juglone silver nano framework for selective cancer cell death by altering the redox states in the cancer cell and selectively inhibiting its growth and proliferation. Conjugation of Juglone with silver nanoparticle reduced the toxicity against normal cells and specifically only inhibited the proliferation of cancer cells. The mechanism of the selective cytotoxic and apoptotic effect on cancer cell was due to down‐regulation of NADPH oxidase 4, Hypoxia‐inducible factor 1α and subdued Pyruvate kinase M2 by arresting Wnt/β catenin signaling through ROS dependent caspase‐3 pathway. Collectively, our findings epitomized that functionalization of nanoparticle gives up a new perspective for adding‐in and tuning the therapeutic values by altering the redox states in cancer cells. Implications of this study opens up a new horizon in modern biomedicine for tuning therapeutic entities to meet the needs of practical applications in complex biological systems.

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Plumbagin caged silver nanoparticle stabilized collagen scaffold for wound dressing

Abstract: Wound dressing material based on nano-biotechnological intervention by caging plumbagin on silver nanoparticle (PCSN) as a multi-site cross-linking agent of collagen scaffolds with potent anti-microbial and wound healing activity.

Cited by 46 publications

References 57 publications

Effect of curcumin caged silver nanoparticle on collagen stabilization for biomedical applications

Effect of curcumin caged silver nanoparticle on collagen stabilization for biomedical applications

Silver Nanomaterials for Wound Dressing Applications

Targeting Pyruvate Kinase M2, β Catenin Signaling by Juglone Silver Nano Framework for Selective Cancer Cell Death

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