Pluripotency and lineages in the mammalian blastocyst: An evolutionary view

Cañón, Susana; Fernandez-Tresguerres, Beatriz; Manzanares, Miguel

doi:10.4161/cc.10.11.15816

Cited by 6 publications

(2 citation statements)

References 44 publications

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“…As discussed below, even though these mechanisms are set in a different context in mammalian development, an understanding of the ancestral mechanism will give us deeper insight into this process in mammals (Cañon et al 2011; Sánchez-Sánchez et al 2011; Marandel et al 2012; Lee et al 2013). …”

Section: Phase 2—from Egg To Embryomentioning

confidence: 99%

Growing an Embryo from a Single Cell: A Hurdle in Animal Life: Figure 1.

O’Farrell

2015

Cold Spring Harb Perspect Biol

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A requirement that an animal be able to feed to grow constrains how a cell can grow into an animal, and it forces an alternation between growth (increase in mass) and proliferation (increase in cell number). A growth-only phase that transforms a stem cell of ordinary proportions into a huge cell, the oocyte, requires dramatic adaptations to help a nucleus direct a 105-fold expansion of cytoplasmic volume. Proliferation without growth transforms the huge egg into an embryo while still accommodating an impotent nucleus overwhelmed by the voluminous cytoplasm. This growth program characterizes animals that deposit their eggs externally, but it is changed in mammals and in endoparasites. In these organisms, development in a nutritive environment releases the growth constraint, but growth of cells before gastrulation requires a new program to sustain pluripotency during this growth.

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Section: Phase 2—from Egg To Embryomentioning

confidence: 99%

Growing an Embryo from a Single Cell: A Hurdle in Animal Life: Figure 1.

O’Farrell

2015

Cold Spring Harb Perspect Biol

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“…The feature of divergent developmental tracks in embryonic and extraembryonic entities in early embryos constitutes an important mechanism that arose during placental mammals’ evolution. This disparate organization of fetal development is essential and effective, since allocating extraembryonic tissue development at the onset of embryogenesis facilitates the eventual separation of the fetus and placenta at birth without complicating the design of the body plan [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Capturing Pluripotency and Beyond

Yeh

Huang

Chen

et al. 2021

Cells

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During the development of a multicellular organism, the specification of different cell lineages originates in a small group of pluripotent cells, the epiblasts, formed in the preimplantation embryo. The pluripotent epiblast is protected from premature differentiation until exposure to inductive cues in strictly controlled spatially and temporally organized patterns guiding fetus formation. Epiblasts cultured in vitro are embryonic stem cells (ESCs), which recapitulate the self-renewal and lineage specification properties of their endogenous counterparts. The characteristics of totipotency, although less understood than pluripotency, are becoming clearer. Recent studies have shown that a minor ESC subpopulation exhibits expanded developmental potential beyond pluripotency, displaying a characteristic reminiscent of two-cell embryo blastomeres (2CLCs). In addition, reprogramming both mouse and human ESCs in defined media can produce expanded/extended pluripotent stem cells (EPSCs) similar to but different from 2CLCs. Further, the molecular roadmaps driving the transition of various potency states have been clarified. These recent key findings will allow us to understand eutherian mammalian development by comparing the underlying differences between potency network components during development. Using the mouse as a paradigm and recent progress in human PSCs, we review the epiblast’s identity acquisition during embryogenesis and their ESC counterparts regarding their pluripotent fates and beyond.

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Pou5f1/oct4 in pluripotency control: Insights from zebrafish

Onichtchouk

2012

Genesis

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Summary: Gastrulation in vertebrates is a conserved process, which involves transition from cellular pluripotency to early precursors of ectoderm, mesoderm, and endoderm. Pluripotency control during this stage is far from being understood. Recent genetic and transcriptomic studies in zebrafish suggest that the core pluripotency transcription factors (TFs) Pou5f1 and TFs of the SoxB1 group are critically involved in large-scale temporal coordination of gene expression during gastrulation. A significant number of evolutionary conserved target genes of Pou5f1 in zebrafish are also involved in stem-cell circuit in mammalian ES cell cultures. Here, I will review the roles of Pou5f1 in development and discuss the evolutionary conservation of Pou5f1 functions and their relation to pluripotency control. genesis 50:75-85, 2012. V V C 2011 Wiley Periodicals, Inc.

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Pluripotency and lineages in the mammalian blastocyst: An evolutionary view

Cited by 6 publications

References 44 publications

Growing an Embryo from a Single Cell: A Hurdle in Animal Life: Figure 1.

Growing an Embryo from a Single Cell: A Hurdle in Animal Life: Figure 1.

Capturing Pluripotency and Beyond

Pou5f1/oct4 in pluripotency control: Insights from zebrafish

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