PM2.5 collected using cyclonic separation causes stronger biological responses than that collected using a conventional filtration method

Honda, Akira; Okuda, Tomoaki; Nagao, Megumi; Miyasaka, Natsuko; Tanaka, Michitaka; Takano, Hirohisa

doi:10.1016/j.envres.2020.110490

Cited by 16 publications

(5 citation statements)

References 36 publications

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“…However, its role in the entry of PM2.5 into the body is unclear. PM2.5 particle stimulation can induce increased expression of DEC205, a surface receptor present in APCs such as DCs and macrophages, which can influence the maturation of APCs ( Honda et al, 2021 ). However, Zheng et al (2020) showed that although PM2.5 increased the proportion of mature DCs, it did not enhance the response of lymphocytes, yet it could stimulate the Th17 phenotype.…”

Section: Primary Membranous Nephropathymentioning

confidence: 99%

“…As a particulate matter that can enter the alveoli, PM2.5’s significant impact on human immunity and epigenetics is not only related to the toxicity of its surface adsorption components. Akiko Honda et al (2021) avoided the contamination of PM2.5 ingredients by extracting materials through cyclone separation technology, thus analyzing the effect of PM2.5 as a powder itself on immune cells and factors. Compared with the organic components of PM2.5, it has a more noticeable impact on reducing cell viability and promoting the release of IL-6.…”

Section: Composition and Mechanism Of Particulate Matter 25mentioning

confidence: 99%

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MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy

Zhou

Dai²,

Jiang³

et al. 2022

Front. Pharmacol.

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Primary membranous nephropathy (PMN), is an autoimmune glomerular disease and the main reason of nephrotic syndrome in adults. Studies have confirmed that the incidence of PMN increases yearly and is related to fine air pollutants particulate matter 2.5 (PM2.5) exposure. These imply that PM2.5 may be associated with exposure to PMN-specific autoantigens, such as the M-type receptor for secretory phospholipase A2 (PLA2R1). Emerging evidence indicates that Th17/Treg turns to imbalance under PM2.5 exposure, but the molecular mechanism of this process in PMN has not been elucidated. As an important indicator of immune activity in multiple diseases, Th17/Treg immune balance is sensitive to antigens and cellular microenvironment changes. These immune pathways play an essential role in the disease progression of PMN. Also, microRNAs (miRNAs) are susceptible to external environmental stimulation and play link role between the environment and immunity. The contribution of PM2.5 to PMN may induce Th17/Treg imbalance through miRNAs and then produce epigenetic affection. We summarize the pathways by which PM2.5 interferes with Th17/Treg immune balance and attempt to explore the intermediary roles of miRNAs, with a particular focus on the changes in PMN. Meanwhile, the mechanism of PM2.5 promoting PLA2R1 exposure is discussed. This review aims to clarify the potential mechanism of PM2.5 on the pathogenesis and progression of PMN and provide new insights for the prevention and treatment of the disease.

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Section: Primary Membranous Nephropathymentioning

confidence: 99%

Section: Composition and Mechanism Of Particulate Matter 25mentioning

confidence: 99%

MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy

Zhou

Dai²,

Jiang³

et al. 2022

Front. Pharmacol.

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“…These findings were consistent with previous studies. It has been reported that PM2.5 exposure promotes the production of pro-inflammatory cytokines such as IL- 1β, IL-6, IL-8, and TNF-α in airway epithelial cells, causing airway inflammation by stimulating lymphocytes, neutrophils, and antigen-presenting cells (Honda et al 2021 ). Another study also reported that PM2.5 exposure up-regulated IL-17 expression, which aggravated neutrophil airway inflammation and mixed neutrophils/eosinophils inflammation in asthmatic mice (Yu et al 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Omega-3 polyunsaturated fatty acids ameliorate PM2.5 exposure induced lung injury in mice through remodeling the gut microbiota and modulating the lung metabolism

Chen

Shi

et al. 2023

Environ Sci Pollut Res

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Short-term or long-term exposure to fine particulate matter (PM2.5) is related to increased incidences of respiratory diseases. This study aimed to investigate the influences of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) supplementation on oxidative stress, inflammation, lung metabolic profile, and gut microbiota in PM2.5-induced lung injury mice. Mice were divided into four groups ( n = 15, per group): two unsupplemented groups, control group and PM2.5 group, and two supplemented groups with ω-3 PUFAs, ω-3 PUFAs group, and ω-3 PUFAs + PM2.5 group. Mice in the supplemented groups were placed on an ω-3 PUFAs-enriched diet (ω-3 PUFAs, 21 g/kg). During the 5th to 6th week of dietary supplementation, mice were exposed to PM2.5 by intra-tracheal instillation. ω-3 PUFAs ameliorate lung histopathological injury, reduce inflammatory responses and oxidative stress, affect lung metabolite profile, and modulate gut microbiota in PM2.5-induced lung injury mice. Thus, supplementary ω-3 PUFAs showed effectiveness in attenuation of PM2.5-induced lung injury, indicating that the interventions exhibited preventive and therapeutic potential. Supplementary information The online version contains supplementary material available at 10.1007/s11356-022-25111-0.

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“…Selection of gas treatment equipment should consider a number of factors such as physical/ chemical characteristics of polluted gas and characteristics and contents of gaseous pollutants and PM. Complex pollution of dusted gases requires the use of multistage treatment systems, including dry and wet cleaning devices, which increases capital and operating costs [17,18]. Apparatus for complex purification of off gases operates in the regime of developed turbulence and is a promising tool for solving this problem [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…Cyclones are recommended for gas pre-treatment, while the secondary treatment phase usually involves other air treatment devices [15][16][17] collecting particles smaller than 20 μm. Multi-stage air treatment systems, however, are more complex and expensive [18]. Analysis of PM separation principles shows that for intensification of the dust collection process in gas-PM systems, the use of centrifugal and vortex interactions in fluid flows are the most effective.…”

Section: Introductionmentioning

confidence: 99%

Experimental investigation of a one-level eight-channel cyclone-separator incorporating quarter-rings

Chlebnikovas

2021

Hem Ind

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The main aim of this investigation was an experimental analysis of the air cleaning efficiency in a mock-up next-generation air cleaning device - one-level 8-channel industrial cyclone-separator with quarter-rings - while changing parameters of the inner structure and the assessment of the effects of dispersion of particulate matter. Therefore, the research was carried out in two stages: the first stage covered the analysis of the efficiency of the multi-channel cyclone with particulate matter of <20 and <50 ?m. During the second stage, a cascade impactor was used to measure the particle collection efficiency in the multi-channel cyclone by fractions: PM1, PM2.5 and PM10. Results of the tests with using the cascade impactor were compared to show changes in the PM composition before and after the multi-channel cyclone-separator. According to the obtained experimental data, the one-level 8-channel cyclone-separator collects 70 to 80 % of PM up to 10 ?m in size, 45 to 60 % of PM up to 2.5 ?m in size and 21 to 25 % of PM up to 1 ?m in size.

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PM2.5 collected using cyclonic separation causes stronger biological responses than that collected using a conventional filtration method

Cited by 16 publications

References 36 publications

MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy

MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy

Omega-3 polyunsaturated fatty acids ameliorate PM2.5 exposure induced lung injury in mice through remodeling the gut microbiota and modulating the lung metabolism

Experimental investigation of a one-level eight-channel cyclone-separator incorporating quarter-rings

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