Pmh39 Relationship Between Clinical Outcomes and Patients' Reported Outcomes in Schizophrenia: The Contribution of the Eq-5d

Scalone, L; Pirfo, Elvezio; Mencacci, Claudio; Ferrannini, Luigi; Berto, Patrizia; Sturkenboom, M; Bernareggi, Micaela; Giustra, MG; Mantovani, LG

doi:10.1016/s1098-3015(10)66940-9

Cited by 2 publications

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“…Correlation with the EQ-5D and measures of symptoms or symptom severity such as the PANSS, symptom checklist-90-revised (SCL-90R), clinical global impression severity of illness scale (CGI-S), and brief psychiatry rating scale (BPRS) were modest or occasionally strong in three studies [20,30,38] . Two studies, however, found associations with the PANSS measures as nonexistent or mostly weak [41,47] . Moderate to strong associations between EQ-5D index scores and depression or anxiety symptom measures were recorded in one study [41] .…”

Section: Resultsmentioning

confidence: 96%

“…Six studies were undertaken internationally across more than one country [8,19–23] ; six studies were undertaken in the USA [24–29] ; three in Germany [30–32] ; two in Ethiopia [33,34] ; two in France [35,36] ; two in Spain [37,38] ; two in the Netherlands [39,40] ; and two in the United Kingdom [41,42] . The remaining six studies took place in Australia [43] , Canada [44] , Denmark [45] , Hong Kong [46] , Italy [47] , and Poland [48] . Two studies did not report the country in which the study was undertaken [49,50] .…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies examined the convergent validity of the EQ-5D [20,30,31,35,38,41,47] and one study examined the construct validity of the EQ-5D by the known groups method [41] ( Table 1 ). Four studies investigated the responsiveness of the EQ-5D [20,40,41,49] .…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen studies examined the construct validity of the SF-36 using convergent validity [8,21,23,28,32,35–37,39,42,44,46–48] and 12 studies examined the construct validity of the SF-36 using known groups validity [19,22–25,28,29,32–34,45,46] . Nine studies investigated the responsiveness of the SF-36 [21,26,27,32,34,36,44,48,50] .…”

Section: Resultsmentioning

confidence: 99%

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How Valid and Responsive Are Generic Health Status Measures, such as EQ-5D and SF-36, in Schizophrenia? A Systematic Review

2011

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ObjectivesGeneric health status measures such as the short form health survey (SF-36) and EuroQol-5D (EQ-5D) are increasingly being used to inform health policy. They are claimed to be applicable across disease areas and have started to be used within mental health research. This review aims to assess the construct validity and responsiveness of four generic health status measures in schizophrenia, including the preference-based SF-6D and EQ-5D.MethodA systematic review of the literature was undertaken. Ten databases were searched from inception to August 2009 and reference lists scrutinized to identify relevant studies. Studies were appraised and data extracted. A narrative synthesis was performed of the evidence on construct validity including known groups validity (detecting a difference in health-related quality of life (HRQL) scores between two different groups such as samples from the general population and people with schizophrenia), convergent validity (strength of association between generic HRQL and other measures (e.g., symptom or functional), and responsiveness. Responsiveness was considered by: 1) differences in generic HRQL measure scores in responders/non-responders and 2) correlation between changes on generic HRQL measures and changes in specific measures obtained from patients and clinicians.ResultsThirty-three studies were identified that provided data on the validity and/or responsiveness of the instruments. Most of the evidence concerns the SF-36 and EQ-5D, and for these instruments there was evidence for known group validity. The evidence for convergent validity and responsiveness was mixed, with studies presenting contradictory results.ConclusionAlthough the evidence base is limited in a number of important respects, including problems with the measures used to develop constructs in the validation studies, it is sufficient to raise doubts about the use of generic measures of health like the EQ-5D and SF-36 in patients with schizophrenia.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

How Valid and Responsive Are Generic Health Status Measures, such as EQ-5D and SF-36, in Schizophrenia? A Systematic Review

2011

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“…66,67,[69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85]88,[92][93][94][95] Although there appears to be strong evidence that the SF-36 is able to distinguish between general population norms and scores of people with schizophrenia (known-group validity), the evidence for convergent validity and responsiveness is less certain ( Table 4). Similar findings exist for the EQ-5D, with mixed evidence for the properties of convergent validity and responsiveness.…”

Section: Schizophreniamentioning

confidence: 99%

A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures

Brazier

Connell

Papaioannou

et al. 2014

Health Technology Assessment

211

187

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This report should be referenced as follows:Brazier J, Connell J, Papaioannou D, Mukuria C, Mulhern B, Peasgood T, et al. A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures. Health Technol Assess 2014;18(34). This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/). Health Technology Assessment is indexed and abstracted inEditorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme or, commissioned/managed through the Methodology research programme (MRP), and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions. To strengthen the evidence base for health research, the MRP oversees and implements the evolving strategy for high quality methodological research. In addition to the MRC and NIHR funding partners, the MRP takes into account the needs of other stakeholders including the devolved administrations, industry R&D, and regulatory/advisory agencies and other public bodies. The MRP funds investigator-led and needsled research proposals from across the UK. In addition to the standard MRC and RCUK terms and conditions, projects commissioned/managed by the MRP are expected to provide a detailed report on the research findings and may publish the findings in the HTA journal, if supported by NIHR funds.The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy o...

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Pmh39 Relationship Between Clinical Outcomes and Patients' Reported Outcomes in Schizophrenia: The Contribution of the Eq-5d

Cited by 2 publications

References 0 publications

How Valid and Responsive Are Generic Health Status Measures, such as EQ-5D and SF-36, in Schizophrenia? A Systematic Review

How Valid and Responsive Are Generic Health Status Measures, such as EQ-5D and SF-36, in Schizophrenia? A Systematic Review

A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures

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