1988
DOI: 10.2214/ajr.151.1.85
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Pneumatosis intestinalis after bone marrow transplantation

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Cited by 84 publications
(61 citation statements)
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“…The use of steroids and its association with development of PI, however, has been well-described. 1,3,8,9 The most commonly accepted mechanism is that steroids cause atrophy of the lymphoid tissue (Peyer's patches) in the gastrointestinal tract, which results in mucosal degradation, allowing dissection of intraluminal air into the intestinal wall. Immunosuppression after cardiac transplantation varies by center with some using steroid-free regimens after a variable time posttransplantation.…”
Section: Discussionmentioning
confidence: 99%
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“…The use of steroids and its association with development of PI, however, has been well-described. 1,3,8,9 The most commonly accepted mechanism is that steroids cause atrophy of the lymphoid tissue (Peyer's patches) in the gastrointestinal tract, which results in mucosal degradation, allowing dissection of intraluminal air into the intestinal wall. Immunosuppression after cardiac transplantation varies by center with some using steroid-free regimens after a variable time posttransplantation.…”
Section: Discussionmentioning
confidence: 99%
“…Concomitant infections including rotavirus and C difficile were seen in 5 of our 8 cases of PI. Both rotavirus 1,3 and C difficile 1,3,7 have been associated with PI. The proposed mechanism for the development of PI with these infectious agents is based on inflammation causing a break in the integrity of the intestinal mucosa, thus allowing intraluminal air to dissect into the bowel wall.…”
Section: Discussionmentioning
confidence: 99%
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“…19 In this case series, steroids were used in combination with other immunosuppressive therapy primarily the calcineurin inhibitors cyclosporine and tacrolimus. Glucocorticoid therapy alone appears to increase significantly the risk of PI development.…”
Section: Discussionmentioning
confidence: 99%