Pneumococcal disease burden from an Indian perspective: Need for its prevention in pulmonology practice

Koul, Parvaiz A; Chaudhari, Sudhir; Chokhani, Ramesh; Christopher, DJ; Dhar, Raja; Doshi, Kumar; Ghoshal, Aloke Gopal; Luhadiya, S K; Mahashur, Ashok; Mehta, Ravindra; Nene, Amita; Rahman, Md. Sadique; Swarnakar, Rajesh

doi:10.4103/lungindia.lungindia_497_18

Cited by 14 publications

(13 citation statements)

References 58 publications

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“…Anemia, renal and cardiac impairments due to deposition of monoclonal light chains were common in MM patients ( 34 ). These complications contribute to both high level of NT-proBNP ( 35 - 40 ) and infections ( 41 - 43 ), which underlines the plausibility of the correlation between NT-proBNP and risk of infection in MM patients.…”

Section: Discussionmentioning

confidence: 96%

Partial immunoparesis contributes to risk of early infections in patients with multiple myeloma

Huang¹,

Wei²,

Wei³

et al. 2021

Transl Cancer Res TCR

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Background Partial immunoparesis, which means at least two suppressed uninvolved immunoglobulins (Igs), had been reported to be associated with poor prognosis in patients with multiple myeloma (MM), but the impact on early infections remains unknown. The purpose of our study was to determine the prognostic implications of partial immunoparesis on early grade ≥3 infections in patients with MM. Methods Herein we retrospectively analyzed the clinical data of 123 MM patients between 2012 and 2020 at Nanfang Hospital. All patients received bortezomib-based regimens. The relationship between early grade ≥3 infections and partial immunoparesis was investigated using Cox regression analysis. Results Our data showed partial immunoapresis was found in 63% MM patients. Partial immunoparesis was significantly related to elevated beta-2-microglobulin (B2M), decreased estimated glomerular filtration rate (eGFR) and progressive international staging system (ISS) stage (P<0.05). Especially, univariate Cox regression analysis showed partial immunoparesis was significantly correlated with early grade ≥3 infections (P=0.003). Moreover, multivariate Cox regression analysis showed partial immunoparesis was an independent significant prognostic factor for early grade ≥3 infections [odds ratio (OR) =3.048; 95% confidence interval (CI): 1.429–6.504; P=0.004]. Furthermore, partial immunoapresis could improve the infection risk model built by Dumontet et al. Conclusions Our study showed that partial immunoparesis could predict early infections in patients with MM, which may be used to identify the high risk patients for infections and guide strategies for infection prevention.

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Section: Discussionmentioning

confidence: 96%

Partial immunoparesis contributes to risk of early infections in patients with multiple myeloma

Huang¹,

Wei²,

Wei³

et al. 2021

Transl Cancer Res TCR

View full text Add to dashboard Cite

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“…23 Furthermore, the risk of developing pneumonia among elderly patients is directly proportional to the severity of the underlying comorbid diseases, such as chronic obstructive pulmonary disease (COPD), asthma, diabetes, heart diseases, and immunocompromised conditions. 7 Comorbid conditions such as cardiovascular and chronic respiratory diseases, Parkinson’s disease, cerebrovascular disease, dementia, epilepsy, chronic liver or renal disease, and HIV are associated with 2- to 4-fold increase in the risk of community-acquired pneumonia. 24 The incidence of pneumonia is 3- to 9-fold in patients with cardiovascular disease alone.…”

Section: Understanding the Need For Vaccination In The Elderlymentioning

confidence: 99%

“…7,8 The guidelines of all key societies in India, such as the Association of Physicians in India, 9 Indian Society of Nephrology, 10 Indian Medical Association 11 and Geriatric Society of India, 12 and the Research Society for the Study of Diabetes in India (RSSDI), 13 discuss adult vaccination. 7 Specific recommendations exist for immunizing adults with comorbid conditions, such as lung disease and chronic kidney failure. Moreover, the recent guidelines emphasize on earlier administration of certain vaccines to avoid the risk of disease and complications.…”

Section: Introductionmentioning

confidence: 99%

“…2,6 Because immunosenescence is common among the elderly, it is essential to immunize the adult population at the earliest. 7,8 The guidelines of all key societies in India, such as the Association of Physicians in India, 9 Indian Society of Nephrology, 10 Indian Medical Association 11 and Geriatric Society of India, 12 and the Research Society for the Study of Diabetes in India (RSSDI), 13 discuss adult vaccination. 7 Specific recommendations exist for immunizing adults with comorbid conditions, such as lung disease and chronic kidney failure.…”

Section: Introductionmentioning

confidence: 99%

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Developing Adult Vaccination Ecosystem in India: Current Perspective and the Way Forward

Ghia

Rambhad

2021

Health Services Research and Managerial Epidemiology

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Introduction: A high burden of vaccine-preventable diseases, increasing elderly population, immunosenescence, and emerging drug resistance emphasize the need for robust adult immunization in India. While immunization guidelines from various societies exist, there is inadequate implementation of the same. Aim: We undertook this narrative review of the adult vaccination ecosystem in India to (i) gain insights into existing adult vaccination practices, (ii) identify barriers to adult vaccination and possible solutions, and (iii) improve collaboration between various stakeholders to help establish adult vaccination centers in the country. Results: Besides the high cost and lack of insurance coverage, the lack of adult vaccination centers contributes to the low coverage of adult immunization. Discussion: These challenges can be addressed through multiple approaches including community awareness and immunization programs, setting up mobile vaccination vans, patient/consumer education, and adequate training of healthcare providers. Successful implementation of these strategies requires active collaboration between the government, hospitals, different stakeholders, and policymakers.

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“…Serotype replacement among asymptomatic carriers has negatively affected the vaccination drive ( Ginsburg & Klugmann, 2017 ). In India, IPD is associated with a high mortality rate despite the availability of treatment ( Koul et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Pneumococcal Vaccine Recommendations for Old-Age Home Indian Residents: A Literature Review

Ghia

Rambhad

2022

Gerontology and Geriatric Medicine

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Advancing age is accompanied by decreased immunity, poor health, and physiological changes, which render the elderly population highly susceptible to infectious diseases. We aim to identify the guidelines for pneumococcal vaccines in old-age facilities in India. We performed an extensive review of Indian literature (indexed and non-indexed publications) from 2010 to 2020 using search strings “Pneumococcal vaccine AND Recommendations AND India,” “Pneumococcal vaccine AND Guidelines AND India,” followed by a hand search to identify the most updated versions of recommendations. We reviewed immunization guidelines recommended by nine medical associations and societies in India—Association of Physicians of India (API), Geriatric Society of India (GSI), Indian Society of Nephrology (ISN), Mass Gathering Advisory Board Consensus Recommendation, Indian Medical Association (IMA), Indian Chest Society and National College of Chest Physicians (ICS-NCCP), Research Society for Study of Diabetes in India (RSSDI), Indian Association of Occupational Health Guidelines for Working Adults (IAOH), and API guidelines for immunization during COVID19 pandemic. All bodies recommend pneumococcal vaccines, sequence and preference of which depend on factors such as age, underlying conditions, and immune status. Integration of society recommendations and their implementation into public and private vaccination programs are required to promote adult immunization.

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Pneumococcal disease burden from an Indian perspective: Need for its prevention in pulmonology practice

Cited by 14 publications

References 58 publications

Partial immunoparesis contributes to risk of early infections in patients with multiple myeloma

Partial immunoparesis contributes to risk of early infections in patients with multiple myeloma

Developing Adult Vaccination Ecosystem in India: Current Perspective and the Way Forward

Pneumococcal Vaccine Recommendations for Old-Age Home Indian Residents: A Literature Review

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