2016
DOI: 10.1080/20469047.2015.1106076
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Pneumococcal-specific IgG levels after 13-valent pneumococcal conjugate vaccination in Nigerian children with sickle cell disease

Abstract: Prevenar 13 provided protective immunity in all vaccinated children but those under 2 years of age who had non-protective levels pre-vaccination benefited the most.

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Cited by 3 publications
(6 citation statements)
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“…High rates of alloimmunization, connective tissue diseases and transplant rejections , as well as incidences of aberrant vaccine reactivity , have bought to surface adaptive immune abnormalities in SCA. Currently, however, little has been done to characterize T and B lymphocyte phenotype, function and contribution to chronic inflammatory diseases in SCA.…”
Section: Adaptive Immune Dysfunction In Scamentioning
confidence: 99%
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“…High rates of alloimmunization, connective tissue diseases and transplant rejections , as well as incidences of aberrant vaccine reactivity , have bought to surface adaptive immune abnormalities in SCA. Currently, however, little has been done to characterize T and B lymphocyte phenotype, function and contribution to chronic inflammatory diseases in SCA.…”
Section: Adaptive Immune Dysfunction In Scamentioning
confidence: 99%
“…However, protracted immune activation has been associated with T cell exhaustion and impaired immune responses , suggesting a balance between the degree and duration of immune activation in modulation of immunization risk. This delicate balance may explain the conundrum where both alloimmunization and impaired responsiveness to vaccines have been observed in individuals with SCA. Indeed, the risk of alloimmunization was found to be higher among SCA patients in the presence of inflammatory events such as acute chest syndrome, vaso‐occlusive crisis and acute febrile illness at the time of transfusion , where circulating levels of the pro‐inflammatory cytokines are high .…”
Section: Immune Activation In Scamentioning
confidence: 99%
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“…A number of innate immune impairments have been described in SCA, including loss of opsonophagocytic activity, which is postulated to confer increased risk of infection with encapsulated bacteria (Brousse et al, 2014). Furthermore, individuals with SCA have increased risk for allo-immunisation, auto-immune diseases, bone marrow transplant rejection (Iannone et al, 2003;Horan et al, 2005;Alkindi et al, 2012;Fasano et al, 2015) and altered vaccine reactivity (John et al, 1984;Ballester et al, 1985;Hord et al, 2002;Purohit et al, 2012;Disu et al, 2016) which has brought to surface adaptive immune aberrations in SCA. Limited studies done have indicated increased immune activation (Hibbert et al, 2005;Keikhaei et al, 2013;Nickel et al, 2015a;Nickel et al, 2015b;van Beers et al, 2015;Vingert et al, 2014Vingert et al, , 2015, dominant T helper 2 (Th2) CD4+ T cell response, regulatory T cell (Treg) dysfunction and loss of immunoglobulin M (IgM)-secreting CD27+IgM high IgD low IgM memory B cells in SCA (Sanhadji et al, 1988;Wang et al, 1988;Rautonen et al, 1992;Musa et al, 2010;Weller et al, 2004).…”
Section: Introductionmentioning
confidence: 99%