PO-0809 Social Communication Questionnaire Factor Structure For Primary School Children With Developmental Disorders Screened As Part Of An Autism Prevalence Study

Abstract

face, frontal bossing, and low-set protruding ears. His neurologic examination revealed normal muscular tonus and normal deep tendon reflexes with clumsy gait. Metabolic screening tests, including tandem mass, urine organic acids, plasma, and urine amino acid profiles were also normal. The patient underwent MRI of the brain as a firstline investigation, and T2 images demonstrated an extensive involvement of the hemispheric, subcortical white matter with a cerebrospinal fluid intensity signal change suggestive of multilocular giant VRS. MR spectroscopy showed no significant signal peak. The karyotype analysis of the patient was 46 XY, and FISH for Angelman syndrome also revealed a normal result. In the 2-year follow-up, the patient showed no neuromotor deterioration and radiological progression.In conclusion, VRS must be differentiated from other cystic lesions of the brain. Phenotypic characteristics of our patient were not compatible with the previously defined syndromes. Background and aims To determine the neurodevelopmental morbidity of preterm infants with periventricular intraventricular haemorrhage, at the age of 4. Methods The patients at the age of 4 were evaluated through neurologic examination and motor assessment by a paediatric neurologist and Denver II Developmental Screening Test by a psychologist. The results were compared with Denver II Developmental Screening Test results which had been made at 3-6 and 6-12 months. Results The total study population consisted of 66 prematurely born children of less than 37 gestational age. When the cases with PVH-IVH were graded with the cranial neuroimaging findings, 62,1% were documented as grade I haemorrhage, 18% as grade II, 6% as grade III and 13.9% as grade IV. Patients with grade III-IV Periventricular Intraventricular Haemorrhage had significantly lower Denver II Developmental Screening Test results at the age of 4, compared with grade I-II PeriventricularIntraventricular Haemorrhage group. Similarly, ≤32 weeks patients had significantly lower Denver II Developmental Screening Test at the age of 4 when compared with >32 weeks patients. Conclusions Children who were born ≤32 gestational weeks and/or patients with grade III-IV periventricular-intraventricular Haemorrhage have an increased risk of neurologic impairment. All premature infants should be evaluated by Denver II Developmental Screening Test in early childhood period of life. Research conducted on children with CHD displays that these children's neurological development is different than the normal population and focuses on the reasons of this difference. Currently, the factor that attains the highest emphasis is the Apo E genotype of the patients. We aimed at revealing the influence of Apo E gene on the neurological development process of children with CHD. Our goal is, predicting the nurological development of children with CHD according to Apo E gene expression, and anchoring the children requiring support, at an earlier stage. We investigated 188 children patients with CHD, in GUTF paediatr...