Podocyte programmed cell death in diabetic kidney disease: Molecular mechanisms and therapeutic prospects

Yang, Haoyu; Sun, Jun; Sun, Aru; Wei, Yu; Xie, Weinan; Xie, Pengfei; Zhang, Lili; Zhao, Linhua; Huang, Yishan

doi:10.1016/j.biopha.2024.117140

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.117140

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Podocyte programmed cell death in diabetic kidney disease: Molecular mechanisms and therapeutic prospects

Haoyu Yang,

Jun Sun,

Aru Sun

et al.

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2024

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Cited by 2 publications

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Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention

Shan,

Cao,

2024

IJGM

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Diabetic kidney disease (DKD) is a form of kidney damage resulting from diabetes and represents a common, severe complication of the disease. Globally, DKD is a leading cause of chronic kidney disease (CKD). DKD occurs in both type 1 and type 2 diabetes patients, with early clinical manifestations including microalbuminuria and hypertension. As the condition progresses, symptoms such as massive proteinuria, hypoalbuminemia, and severe edema may appear. The key to treating DKD lies in controlling blood glucose and blood pressure, reducing proteinuria, and slowing the deterioration of kidney function. Acupuncture, a traditional Chinese medicine treatment, has shown some therapeutic effects on DKD through mechanisms such as regulating blood glucose, improving renal blood flow and microcirculation, antioxidation and anti-inflammation, and modulating gut microbiota.

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Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention

Shan,

Cao,

2024

IJGM

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Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets

Zhong,

Wang,

Zhang

2024

IJMS

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Cell deaths maintain the normal function of tissues and organs. In pathological conditions, the abnormal activation or disruption of cell death often leads to pathophysiological effects. Diabetic kidney disease (DKD), a significant microvascular complication of diabetes, is linked to high mortality and morbidity rates, imposing a substantial burden on global healthcare systems and economies. Loss and detachment of podocytes are key pathological changes in the progression of DKD. This review explores the potential mechanisms of apoptosis, necrosis, autophagy, pyroptosis, ferroptosis, cuproptosis, and podoptosis in podocytes, focusing on how different cell death modes contribute to the progression of DKD. It recognizes the limitations of current research and presents the latest basic and clinical research studies targeting podocyte death pathways in DKD. Lastly, it focuses on the future of targeting podocyte cell death to treat DKD, with the intention of inspiring further research and the development of therapeutic strategies.

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Podocyte programmed cell death in diabetic kidney disease: Molecular mechanisms and therapeutic prospects

Cited by 2 publications

References 108 publications

Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention

Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention

Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets

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