Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting

Chen, Huabing; Chang, Xueling; Du, Danrong; Liu, Wei; Liu, Jie; Weng, Ting; Yang, Yajiang; Xu, Huibi; Yang, Xiangliang

doi:10.1016/j.jconrel.2005.09.052

Cited by 295 publications

(148 citation statements)

References 30 publications

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…The results had showed the penetration of P-SLN with low particle size into stratum corneum along the skin surface furrow and the consequent controlled release of podophyllotoxin might lead to the epidermal targeting. Furthermore, P-SLN provides a good epidermal targetting effect and may be a promising carrier for topical delivery of podophyllotoxin [109] .…”

Section: Recent Advances Of Bioenhancersmentioning

confidence: 99%

Bioavailability enhancers of herbal origin: An overview

Kesarwani

Gupta

2013

Asian Pacific Journal of Tropical Biomedicine

400

197

View full text Add to dashboard Cite

Section: Recent Advances Of Bioenhancersmentioning

confidence: 99%

Bioavailability enhancers of herbal origin: An overview

Kesarwani

Gupta

2013

Asian Pacific Journal of Tropical Biomedicine

400

197

View full text Add to dashboard Cite

“…Minoxidil loaded in chitosan nanoparticle [32] for example has been utilized to achieve sustain drug release about twice more than previous studies using microparticles [16]. In addition, nanoparticles have shown the potential for delivering drugs via the follicles [17,18].…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Chitosan Nanoparticles for Percutaneous Delivery of Caffeine: Preparation, Characterization and in Vitro Release Studies

et al. 2018

View full text Add to dashboard Cite

Objective: Chitosan (CS)-tripolyphosphate (TPP)-nanoparticles (NPs) have been extensively studied during the past few decades due to their wellrecognized applicability in various fields. The present study attempts to optimise the development of these nanoparticles to enhance the percutaneous delivery of caffeine.Methods: CS-TPP-NPs were prepared via ionic cross-linking of CS and TPP and were characterized. The influence of several formulation conditions (CS: TPP mass ratio and concentration of caffeine) and process parameters (stirring speed, stirring time and ultra-sonication time) on the colloidal characteristics of CS-TPP-NPs were investigated and the resulting nanoparticles were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) and x-ray diffraction (XRD) analyses. Physicochemical properties, including particle size, zeta potential and polydispersity index (PDI) were examined, and in vitro release studies were conducted to ascertain the release profile of caffeine from the nanoparticles. In addition, the colloidal stability of the prepared NPs was also assessed on storage.Results: Process parameters appeared to exert a significant effect on the physicochemical characteristics of the CS-TPP-NPs. The CS-TPP-NPs prepared under optimum conditions (CS concentration of 0.2 mg/ml, CS: TPP volume ratio of 25:12 ml, stirred at 700 rpm for 60 min, with 0.97 mg/ml caffeine concentration and treatment with low ultra-sonication for 30 min) had shown a mean particle size of ~143.43±1.69 nm, zeta potential of+43.13±1.10 mV, PDI of ~0.30±0.01. A drug loading capacity and encapsulation efficiency of 48.89% and 60.69%, respectively, were obtained. Cumulative release study for drug-loaded CS-NPs was significantly (p<0.001, paired t-test) higher (58.7% caffeine released) compared to control formulation (41.5% caffeine released) after 72 h. Stability studies conducted for 28 d showed that caffeine-loaded CS-NPs degraded much quicker when stored at 25 ⁰C than 4 ⁰C. It was also noted that caffeine-loaded CS-NPs in the freeze-dried form were unstable as the surface charge of nanoparticles dropped from positive zeta potential to-3.55 mV within 2 d at 4 ⁰C and at 25 ⁰C, surface charge dropped to-3.16 mV within 14 d of the experiment. Conclusion:Chitosan (CS)-tripolyphosphate (TPP)-nanoparticles (NPs) appear to be a promising strategy to achieve sustained percutaneous delivery of caffeine.

show abstract

“…Over the past few years many different drugs had been successfully incorporated in lipid nano-or microparticles [20,[26][27][28]. Relatively higher drug encapsulation efficiency was one of the major advantages of lipid nanoparticles.…”

Section: Drug Entrapment Efficiency and Loading Capacitymentioning

confidence: 99%

Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: Development and in vitro characterization

Mendoza

Rayo

Mollinedo

et al. 2008

European Journal of Pharmaceutics and Biopharmaceutics

View full text Add to dashboard Cite

The ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine, edelfosine ) is the prototype molecule of a promising class of antitumour drugs named alkyl-lysophospholipid analogues (ALPs) or antitumor ether lipids. This drug presents a very important drawback as can be the dose depending haemolysis when administered intravenously. Lipid nanoparticles have been lately proposed for different drug encapsulation as an alternative to other controlled release delivery systems, such as liposomes or polymeric nanoparticles. The aim of this study was to develop a lipid nanoparticulate system that would decrease systemic toxicity as well as improve the therapeutic potential of the drug. Lipids employed were Compritol ® 888 ATO and stearic acid. The nanoparticles were characterized by photon correlation spectroscopy for size and size distribution, and atomic force microscopy (AFM) was used for the determination of morphological properties. By both differential scanning calorimetry (DSC) and X-ray diffractometry, crystalline behaviour of lipids and drug was assessed.The drug encapsulation efficiency and the drug release kinetics under in vitro conditions were measured by HPLC-MS. It was concluded that Compritol ® presents advantages as a matrix material for the manufacture of the nanoparticles and for the controlled release of edelfosine.

show abstract

Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting

Cited by 295 publications

References 30 publications

Bioavailability enhancers of herbal origin: An overview

Bioavailability enhancers of herbal origin: An overview

Self-Assembled Chitosan Nanoparticles for Percutaneous Delivery of Caffeine: Preparation, Characterization and in Vitro Release Studies

Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: Development and in vitro characterization

Contact Info

Product

Resources

About