Podoplanin and E-cadherin Expression in Preoperative Incisional Biopsies of Oral Squamous Cell Carcinoma Is Related to Lymph Node Metastases

Foschini, Maria Pia; Leonardi, Elisa; Eusebi, Leonardo Henry; Farnedi, Anna; Poli, Tito; Tarsitano, Achille; Cocchi, R; Marchetti, Claudio; Gentile, Luciano; Sesenna, Enrico; Marucci, Gianluca; Montebugnoli, Lucio

doi:10.1177/1066896912471851

Cited by 26 publications

(30 citation statements)

References 18 publications

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“…Several studies show positive correlation between E-cadherin expression and nodal metastasis (Tanaka et al, 2003;Bosch et al, 2005;Foschini et al, 2008;Foschini et al, 2013) but others including our study, dispute this (Mahomed et al, 2007;Lopes et al, 2009;Mostaan et al, 2011;Ukpo et al, 2012;Rosado et al, 2013). An editorial by Cerezo (2011) DOI:http://dx.doi.org/10.7314/APJCP.2014.15.5.2145 Changed Expression of E-cadherin andGalectin-9 …”

Section: Discussioncontrasting

confidence: 51%

“…Consideration of use in combinations with other markers such as CD44 (Mostaan et al, 2011), podoplanin (Foschini et al, 2013), truncated dominant-negative isoform of p63 (DNp63) (Foshini et al, 2008), vimentin (Nijkamp et al, 2011), α-catenin (Tanaka et al, 2003) and β-catenin (Tanaka et al, 2003;Mahomed et al, 2007;Rosado et al, 2013) is perhaps a more feasible option.…”

Section: In Oral Sccs But No Potential As Prognostic Markersmentioning

confidence: 99%

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Changed Expression of E-cadherin and Galectin-9 in Oral Squamous Cell Carcinomas but Lack of Potential as Prognostic Markers

Kallarakkal²,

Abraham³

2014

Asian Pacific Journal of Cancer Prevention

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Background: The survival rate for oral squamous cell carcinoma (OSCC) has remained generally unchanged in the past three decades, underlining the need for more biomarkers to be developed to aid prognostication and effective management. The prognostic potential of E-cadherin expression in OSCCs has been variable in previous studies while galectin-9 expression has been correlated with improved prognosis in other cancers. The aim of the present study was to investigate the expression of galectin-9 and E-cadherin in OSCC and their potential as prognostic biomarkers. Materials and Methods: E-cadherin and Galectin-9 expression was examined by immunohistochemistry in 32 cases of OSCC of the buccal mucosa (13 with and 19 without lymph node metastasis), as well as 6 samples of reactive lesions and 5 of normal buccal mucosa. Results: The expression of E-cadherin in OSCC was significantly lower than the control tissues but galectin-9 expression was conversely higher. Median E-cadherin HSCOREs between OSCCs positive and negative for nodal metastasis were not significantly different. Mean HSCOREs for galectin-9 in OSCC without lymph node metastasis (127.7±81.8) was higher than OSCC with lymph node metastasis (97.9±62.9) but this difference was not statistically significant. Conclusions: E-cadherin expression is reduced whilst galectin-9 expression is increased in OSCC. However, the present results suggest that E-cadherin and galectin-9 expression may not be useful as prognostic markers for OSCC.

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Section: Discussioncontrasting

confidence: 51%

Section: In Oral Sccs But No Potential As Prognostic Markersmentioning

confidence: 99%

Changed Expression of E-cadherin and Galectin-9 in Oral Squamous Cell Carcinomas but Lack of Potential as Prognostic Markers

Kallarakkal²,

Abraham³

2014

Asian Pacific Journal of Cancer Prevention

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“…Alguns estudos verificaram que a ezrina encontrava-se co-localizada nas mesmas regiões celulares que a podoplanina (MARTIN-VILLAR et al, 2005) uma proteína que se expressa no front de invasão de carcinomas espinocelulares, incluindo aqueles localizados na boca (YUAN et al, 2006;YAMANASHI et al, 2009;CARVALHO et al, 2010;FUNAYAMA et al, 2011;HUBER et al, 2011;KREPPEL et al, 2011;LEE et al, 2011;BARTULI et al, 2012;INOUE et al, 2012;ITO et al, 2012;TONG et al, 2012;DOS SANTOS ALMEIDA et al, 2013;DUNKEL et al, 2013;FOSCHINI et al, 2013 (BREITENEDER-GELLEF et al, 1999;MARGARITESCU et al, 2010).…”

Section: Introductionunclassified

“…Recentemente, investigações em diferentes tipos de cânceres mostraram que a podoplanina se expressa também nas células neoplásicas malignas (YAMANASHI et al, 2009;CARVALHO et al, 2010;LEE et al, 2011;SUZUKI et al, 2011;ITO et al, 2012;TONG et al, 2012), inclusive no carcinoma espinocelular de boca (YUAN et al, 2006;VORMITTAG et al, 2009;KREPPEL et al, 2010;MARGARITESCU et al, 2010;HUBER et al, 2011;FUNAYAMA et al, 2011;KREPPEL et al, 2011;BARTULI et al, 2012;INOUE et al, 2012;DOS SANTOS ALMEIDA et al, 2013;DUNKEL et al, 2013;FOSCHINI et al, 2013).…”

Section: Introductionunclassified

“…Embora não se conheça o papel exato da podoplanina no câncer de boca, sua alta expressão pelas células malignas destes tumores vem sendo associada à presença de metástases linfonodais e a uma pior sobrevivência do paciente (YUAN et al, 2006;VORMITTAG et al, 2009;KREPPEL et al, 2010;HUBER et al, 2011;FUNAYAMA et al, 2011;KREPPEL et al 2011;BARTULI et al, 2012;FOSCHINI et al, 2013).…”

Section: Introductionunclassified

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Correlação da expressão de podoplanina, ezrina e Rho-A em carcinomas espinocelulares de lábio inferior

Assáo¹

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High expression of podoplanin in squamous cell carcinoma of the tongue occurs predominantly in patients ≤40 years but does not correlate with tumour spread

Sgaramella

Jonsson

Boldrup

et al. 2015

The Journal of Pathology CR

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More than 30% of patients with squamous cell carcinoma (SCC) of the mobile tongue have clinically undetectable lymph node metastasis. Tumour cells can spread as single cells or collectively. A protein known to play a role in both processes is podoplanin, which is expressed in endothelial cells not only in lymph vessels but also in some aggressive tumours with high invasive and metastatic potential. Here we studied samples from 129 patients with primary SCC of the tongue for expression of podoplanin using immunohistochemistry. mRNA levels were analysed in another 27 cases of tongue SCC with adjacent clinically tumour‐free tongue tissue and 14 tongue samples from healthy donors. Higher levels of podoplanin were seen in tumours compared to both normal tongue and clinically normal tongue in the tumour vicinity. No association was found between levels of podoplanin, presence of lymph node metastases or other clinical factors. Patients aged 40 or less were more likely to express high levels of podoplanin protein compared to older patients (p = 0.027). We conclude that levels of podoplanin in primary tongue SCCs are not associated with lymph node metastases. However, tongue SCCs arising in young patients (≤40 years of age) are more likely to express high levels of podoplanin than tongue SCCs that arise in the more elderly. The data suggest that podoplanin has a distinctive role in young patients, who are known to have a poor prognosis: these patients may, therefore, benefit from podoplanin inhibitory therapies.

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Podoplanin and E-cadherin Expression in Preoperative Incisional Biopsies of Oral Squamous Cell Carcinoma Is Related to Lymph Node Metastases

Cited by 26 publications

References 18 publications

Changed Expression of E-cadherin and Galectin-9 in Oral Squamous Cell Carcinomas but Lack of Potential as Prognostic Markers

Changed Expression of E-cadherin and Galectin-9 in Oral Squamous Cell Carcinomas but Lack of Potential as Prognostic Markers

Correlação da expressão de podoplanina, ezrina e Rho-A em carcinomas espinocelulares de lábio inferior

High expression of podoplanin in squamous cell carcinoma of the tongue occurs predominantly in patients ≤40 years but does not correlate with tumour spread

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