2017
DOI: 10.1172/jci.insight.92321
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Podoplanin is a negative regulator of Th17 inflammation

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Cited by 32 publications
(38 citation statements)
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“…For example, the transmembrane protein podoplanin (PDPN) is highly expressed on Th17 cells and acts as a negative regulator of Th17 pathogenicity. 243 Mice with a selective depletion of PDPN in T cells show enhanced EAE severity with increased T-cell infiltration into the CNS. 244 Interestingly, PDPN was also identified as an important regulator in cancer.…”
Section: Shared Features Of Exhausted Tumor-infiltrating T Cells and mentioning
confidence: 99%
“…For example, the transmembrane protein podoplanin (PDPN) is highly expressed on Th17 cells and acts as a negative regulator of Th17 pathogenicity. 243 Mice with a selective depletion of PDPN in T cells show enhanced EAE severity with increased T-cell infiltration into the CNS. 244 Interestingly, PDPN was also identified as an important regulator in cancer.…”
Section: Shared Features Of Exhausted Tumor-infiltrating T Cells and mentioning
confidence: 99%
“…Podoplanin and CLEC-2 have been reported to be antiinflammatory in an experimental autoimmune encephalomyelitis (EAE) model in mice. An increase in EAE severity is seen on deletion of podoplanin or platelet CLEC-2, and EAE is reduced upon overexpression of podoplanin on Th17 cells associated with an increased rate of resolution of inflammation, suggesting that podoplanin is a nonpathogenic marker of Th17 cells and that the podoplanin/CLEC-2 axis promotes resolution (129)(130)(131). In contrast, overexpression of podoplanin on Th17 T cells and fibroblasts correlates with increased inflammation and clinical severity in rheumatoid arthritis (132), showing that the beneficial role of podoplanin is disease dependent.…”
Section: Figure 3 Multiple Roles Of Clec-2 and Gpvi In Thrombo-inflamentioning
confidence: 99%
“…The Mac-1 is critical for the adhesion and migration into the extracellular matrix (36)(37)(38)(39). In this study Mac-1 positive cells were detected in healthy mouse kidneys with P. gingivalis LPS administration (Fig.…”
Section: Distribution Of Macrophages In Diabetic Mouse Kidneys With Pmentioning
confidence: 50%