Polar coordinate active-matrix digital microfluidics for high-resolution concentration gradient generation

Zhang, Bingbing; Fu, Jinxin; Du, Maohua; Jin, Kai; Huang, Qi; Li, Jiahao; Wang, Dongping; Hu, Siyi; Li, Jinhua; Ma, Hanbin

doi:10.1039/d3lc00979c

Lab Chip

2024

DOI: 10.1039/d3lc00979c

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Polar coordinate active-matrix digital microfluidics for high-resolution concentration gradient generation

Bingbing Zhang,

Jinxin Fu,

Maohua Du

et al.

Abstract: Automated concentration gradient generation is one of the most important applications of lab-on-a-chip devices. Digital microfluidics is a unique platform that can effectively achieve digitalized gradient concentration preparation. However, dynamic...

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Cited by 4 publications

References 31 publications

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Compressibility effects in microchannel flows between two-parallel plates at low reynolds and mach numbers: Numerical analysis

Elgack,

Al-Souqi,

Hamdan

et al. 2024

International Journal of Thermofluids

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Compressibility effects in microchannel flows between two-parallel plates at low reynolds and mach numbers: Numerical analysis

Elgack,

Al-Souqi,

Hamdan

et al. 2024

International Journal of Thermofluids

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Artificial intelligence-enabled multipurpose smart detection in active-matrix electrowetting-on-dielectric digital microfluidics

Jia,

Chang,

et al. 2024

Microsyst Nanoeng

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An active-matrix electrowetting-on-dielectric (AM-EWOD) system integrates hundreds of thousands of active electrodes for sample droplet manipulation, which can enable simultaneous, automatic, and parallel on-chip biochemical reactions. A smart detection system is essential for ensuring a fully automatic workflow and online programming for the subsequent experimental steps. In this work, we demonstrated an artificial intelligence (AI)-enabled multipurpose smart detection method in an AM-EWOD system for different tasks. We employed the U-Net model to quantitatively evaluate the uniformity of the applied droplet-splitting methods. We used the YOLOv8 model to monitor the droplet-splitting process online. A 97.76% splitting success rate was observed with 18 different AM-EWOD chips. A 99.982% model precision rate and a 99.980% model recall rate were manually verified. We employed an improved YOLOv8 model to detect single-cell samples in nanolitre droplets. Compared with manual verification, the model achieved 99.260% and 99.193% precision and recall rates, respectively. In addition, single-cell droplet sorting and routing experiments were demonstrated. With an AI-based smart detection system, AM-EWOD has shown great potential for use as a ubiquitous platform for implementing true lab-on-a-chip applications.

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Microscale Flow Control and Droplet Generation Using Arduino-Based Pneumatically-Controlled Microfluidic Device

Park,

Choe,

Kim

2024

Biosensors

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Microfluidics are crucial for managing small-volume analytical solutions for various applications, such as disease diagnostics, drug efficacy testing, chemical analysis, and water quality monitoring. The precise control of flow control devices can generate diverse flow patterns using pneumatic control with solenoid valves and a microcontroller. This system enables the active modulation of the pneumatic pressure through Arduino programming of the solenoid valves connected to the pressure source. Additionally, the incorporation of solenoid valve sets allows for multichannel control, enabling simultaneous creation and manipulation of various microflows at a low cost. The proposed microfluidic flow controller facilitates accurate flow regulation, especially through periodic flow modulation beneficial for droplet generation and continuous production of microdroplets of different sizes. Overall, we expect the proposed microfluidic flow controller to drive innovative advancements in technology and medicine owing to its engineering precision and versatility.

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Polar coordinate active-matrix digital microfluidics for high-resolution concentration gradient generation

Abstract: Automated concentration gradient generation is one of the most important applications of lab-on-a-chip devices. Digital microfluidics is a unique platform that can effectively achieve digitalized gradient concentration preparation. However, dynamic...

Cited by 4 publications

References 31 publications

Compressibility effects in microchannel flows between two-parallel plates at low reynolds and mach numbers: Numerical analysis

Compressibility effects in microchannel flows between two-parallel plates at low reynolds and mach numbers: Numerical analysis

Artificial intelligence-enabled multipurpose smart detection in active-matrix electrowetting-on-dielectric digital microfluidics

Microscale Flow Control and Droplet Generation Using Arduino-Based Pneumatically-Controlled Microfluidic Device

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