1The present research investigates the influence of culture on telemedicine adoption and patient information privacy, security, and policy. The results, based on the SEM analysis of the data collected in the United States, demonstrate that culture plays a significant role in telemedicine adoption. The results further show that culture also indirectly influences telemedicine adoption through information security, information privacy, and information policy. Our empirical results further indicate that information security, privacy, and policy impact telemedicine adoption.