Polish Achievements in Bioactive Compound Production From In Vitro Plant Cultures

Pietrosiuk, Agnieszka; Budzianowska, Anna; Budzianowski, Jaromir; Ekiert, Halina; Jeziorek, Małgorzata; Kawiak, Anna; Kikowska, Małgorzata; Krauze-Baranowska, Mirosława; Królicka, Aleksandra; Kuźma, Łukasz; Łuczkiewicz, Maria; Malarz, Janusz; Matkowski, Adam; Stojakowska, Anna; Sykłowska-Baranek, Katarzyna; Szopa, Agnieszka; Szypuła, Wojciech J.; Thiem, Barbara; Zielińska, Sylwia

doi:10.5586/asbp.9110

Cited by 8 publications

(4 citation statements)

References 143 publications

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“…The heterocyclic system of quinolizidine is unique in terms of its chemical structure, and huperzine A (Figure 3) is a potent and reversible acetylcholinesterase inhibitor that is not often described in organic chemistry or phytochemistry 69–71 …”

Section: Resultsmentioning

confidence: 99%

“…68 The heterocyclic system of quinolizidine is unique in terms of its chemical structure, and huperzine A (Figure 3) is a potent and reversible acetylcholinesterase inhibitor that is not often described in organic chemistry or phytochemistry. [69][70][71] Huperzia serrata extract standardized for huperzine A, and also huperzine A itself, has become common ingredients found on the labels of various categories of DS, including nootropics, pre-workouts, and thermogenics. 41,72 Huperzia serrata (with or without standardization to huperzine A) was found on the label of 10 (20%) of the 50 selected DS reviewed.…”

Section: Acetylcholinesterase Inhibitors Including Huperzine Amentioning

confidence: 99%

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Unauthorized ingredients in “nootropic” dietary supplements: A review of the history, pharmacology, prevalence, international regulations, and potential as doping agents

Jędrejko,

Catlin,

Stewart

et al. 2023

Drug Testing and Analysis

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The first nootropic prohibited in sport was fonturacetam (4-phenylpiracetam, carphedon) in 1998. Presented here 25 years later is a broad-scale consideration of the history, pharmacology, prevalence, regulations, and doping potential of nootropics viewed through a lens of 50 selected dietary supplements (DS) marketed as "cognitive enhancement," "brain health," "brain boosters," or "nootropics," with a focus on unauthorized ingredients. Nootropic DS have risen to prominence over the last decade often as multicomponent formulations of bioactive ingredients presenting compelling pharmacological questions and potential public health concerns. Many popular nootropics are unauthorized food or DS ingredients according to the European Commission including huperzine A, yohimbine, and dimethylaminoethanol; unapproved pharmaceuticals like phenibut or emoxypine (mexidol); previously registered drugs like meclofenoxate or reserpine; EU authorized pharmaceuticals like piracetam or vinpocetine; infamous doping agents like methylhexaneamine or dimethylbutylamine; and other investigational substances and peptides. Several are authorized DS ingredients in the United States resulting in significant global variability as to what qualifies as a legal nootropic. Prohibited stimulants or ß2-agonists commonly used in "pre-workout," "weight loss," or "thermogenic" DS such as octodrine, hordenine, or higenamine are often stacked with nootropic substances. While stimulants and ß2-agonists are defined as doping agents by the World Anti-Doping Agency (WADA), many nootropics are not, although some may qualify as non-approved substances or related substances under catch-all language in the WADA Prohibited List. Synergistic combinations, excessive dosing, or recently researched pharmacology may justify listing certain nootropics as doping agents or warrant additional attention in future regulations.

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Section: Resultsmentioning

confidence: 99%

Section: Acetylcholinesterase Inhibitors Including Huperzine Amentioning

confidence: 99%

Unauthorized ingredients in “nootropic” dietary supplements: A review of the history, pharmacology, prevalence, international regulations, and potential as doping agents

Jędrejko,

Catlin,

Stewart

et al. 2023

Drug Testing and Analysis

View full text Add to dashboard Cite

show abstract

“…Furthermore, genetic transformation and elicitation using different growth regulators (e.g., methyl jasmonate, yeast extract, and chitosan) have been studied to increase the production of active metabolites and, in consequence, the biological potential of Droseraceae and Nepenthaceae, and it was found that carnivorous plants are susceptible to elicitation [69,74,184,193,195]. For instance, the beneficial effect on naphthoquinones content in the roots of Dr. burmanii and Dr. indica was observed for yeast extract [186,196].…”

Section: Possibility Of Cultivationmentioning

confidence: 99%

Biological Potential of Carnivorous Plants from Nepenthales

et al. 2023

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Since Charles Darwin and his book carnivorous plants have aroused interest and heated debate. In addition, there is growing interest in this group of plants as a source of secondary metabolites and in the application of their biological activity. The aim of this study was to trace the recent literature in search of the application of extracts obtained from families Droseraceae, Nepenthaceae, and Drosophyllaceae to show their biological potential. The data collected in the review clearly indicate that the studied Nepenthales species have great biological potential in terms of antibacterial, antifungal, antioxidant, anti-inflammatory, and anticancer use. We proposed that further investigations should include: (i) bioactivity-guided investigations of crude plant extract to connect a particular type of action with a specific compound or a group of metabolites; (ii) a search for new bioactive properties of carnivorous plants; (iii) establishment of molecular mechanisms associated with specific activity. Furthermore, further research should be extended to include less explored species, i.e., Drosophyllum lusitanicum and especially Aldrovanda vesiculosa.

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“…For this purpose, various types of in vitro cultures have been performed (e.g., shoot, callus, root, and suspension cultures), and various treatments have been used to stimulate the biosynthesis of secondary metabolites (Kikowska et al, 2022). is issue has been discussed in a separate publication (Pietrosiuk et al, 2022).…”

Section: Selected Achievements Of Biotechnological Researchmentioning

confidence: 99%

Application of in vitro culture and biotechnology for the protection of endangered national plant species in Poland

Pawłowska,

Ptak

2023

Acta Soc Bot Pol

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In Poland, research applying in vitro techniques to protect endangered national plant species began 30 years ago. Scientists from approximately 10 research centers comprising universities, research institutes, and botanical gardens, have conducted the most significant studies to date. In this paper, we review the knowledge and experience accumulated over the last few decades regarding the micropropagation of more than 40 wild Polish plant species. This research covered all groups of plants: ferns, monocotyledons, dicotyledons, and woody species. Most studies have focused on dicotyledon classes and species belonging to eight botanical families. Among them the first research was on the use of in vitro cultures for the protection of endangered plants of the Droseraceae family. Several micropropagation protocols have been established, in which organogenesis is a more frequently used morphogenetic pathway for plant propagation than somatic embryogenesis. The major aspects investigated included the selection of an appropriate initial explant and optimization of the medium composition. An embryogenic cell suspension culture was established, and a technology for obtaining artificial seeds was developed. Some studies have extended the acclimatization of plants to ex vitro conditions. Recent studies, apart from in vitro techniques, have also used molecular biology and genetic techniques, which may support the implementation of plant regeneration systems developed in Poland to protect endangered species.

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Polish Achievements in Bioactive Compound Production From In Vitro Plant Cultures

Cited by 8 publications

References 143 publications

Unauthorized ingredients in “nootropic” dietary supplements: A review of the history, pharmacology, prevalence, international regulations, and potential as doping agents

Unauthorized ingredients in “nootropic” dietary supplements: A review of the history, pharmacology, prevalence, international regulations, and potential as doping agents

Biological Potential of Carnivorous Plants from Nepenthales

Application of in vitro culture and biotechnology for the protection of endangered national plant species in Poland

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