Left-right political auto-identification has been used widely in socio-political research to interpret and organize political attitudes and opinions. In this paper we analyse whether the meaning of left-right orientation is the same in Eastern Europe and Western Europe. Using data from two big European survey programmes, European Social Survey and EuropeanValues Study, we show that while citizens' support for economic liberalism is positively related to their left-right political auto-identification, their support for cultural liberalism is negatively related. More importantly, we also present evidence for the regional diversity hypothesis, which shows that this pattern was more prominent among citizens of Western European countries than those of Eastern European countries. The results confirm the specificity of Eastern Europe when it comes to relationships between political autoidentification and other beliefs that are traditionally linked, implying that the concept of leftright political auto-identification cannot be transferred mechanically between Eastern Europe and Western Europe.