Pollen extracts reduce the hepatotoxicity of paracetamol in mice

Abstract

Cernitins are preparations obtained from plant pollen which contain numerous compounds of potential biological significance. This work deals with the influence of cernitins upon acute paracetamol toxicity in mice. The survival rate and indices of hepatic injury: aminotransferase and alkaline phosphatase activities, bilirubin level in serum, glutathione and cytochrome P-450 content in liver, liver weight, histopathologic picture of the liver and presence of glycogen and lipids in stained liver sections, under different experimental protocols, were determined. It was found that cernitins are able to increase the survival rate of mice and reduce liver injury in acute paracetamol poisoning. Cernitins are more effective when administered after, rather than before, a dose of paracetamol. The possible mechanism through which cernitins may act is discussed.

Bee Pollen: Chemical Composition and Therapeutic Application

“…However, when it was administered with toxic substances, it protected liver cells from their harmful effect, which indicates, in turn, its ability to prevent toxication. In the detoxifying process, an important role is played by polyphenols, mainly flavonoids and phenolic acids [ 28 – 31 ].…”

Antitumour potential of pollen extract on lewis lung carcinoma implanted intraperitoneally in syngeneic mice

“…, 1986), antiinflammatory properties (It0 et al, 1984;Loschen and Ebeling, 1992) and inhibitory potential on hormonedependent growth of tissues of benign prostatic hyperplasia in nude mice (Wagner et al, 1992) or cultivated prostate cells in uifro (Habib, 1992). Pollen extract also has been reported to reduce hepatotoxicity of paracetamol (Juzwiak et al, 1992) and to prevent poisoning caused by organic solvents (Ceglecka et al, 1992). Numerous substances have been isolated from pollen extract; amino acids, carbohydrates, deoxyribosides, enzymes, coenzymes, vitamins, minerals, trace elements, sterols (Kvanta, 1968;Nielsen and Holmstrom, 1957) and polyunsaturated fatty acids (Seppanen ef al., 1989).…”

Effect of bee pollen extract on lead-induced toxicity in rat testis

“…In addition, the AST and ALT levels correlated with the concentration of the pollen given. Moreover, Pollen extracts reduce the hepatotoxicity of paracetamol in Mice (Juźwiak et al, 1992).…”