Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study

Coster, Sam De; Koppen, Gudrun; Bracke, Marc; Schroijen, Carmen; Hond, Elly Den; Nelen, Vera; Mieroop, Els Van de; Bruckers, Liesbeth; Bilau, Maaike; Baeyens, Willy; Schoeters, Greet; Larebeke, Nik van

doi:10.1186/1476-069x-7-26

Cited by 47 publications

(39 citation statements)

References 78 publications

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“…A Stratified Clustered Multi-Stage Design was used to select 775 men and 808 women (n=1583) aged 50 to 65 as a random sample of the population of the areas under study as described by De Coster et al (2008). Sampling took place in three steps: first by study area, secondly by sub-municipality entities for access to participants, and thirdly by selection of the participants in accordance with the inclusion criteria.…”

Section: Adultsmentioning

confidence: 99%

Internal exposure to pollutants and body size in Flemish adolescents and adults: Associations and dose–response relationships

Dhooge

Hond

Koppen

et al. 2010

Environment International

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Section: Adultsmentioning

confidence: 99%

Internal exposure to pollutants and body size in Flemish adolescents and adults: Associations and dose–response relationships

Dhooge

Hond

Koppen

et al. 2010

Environment International

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“…The study areas, comprising 22% of the Flemish territory, 20% of the Flemish population and 20% of the Flemish municipalities are described in detail by De Coster et al (2008) and Schroijen et al (2008). Briefly, we sampled from industrial sites, harbours, rural areas, around waste incinerators and in a fruit area: ''Antwerp'' is an industrial city with 404000 inhabitants and very dense traffic; ''Ghent'' is a smaller industrial city with 213000 inhabitants; ''Antwerp harbour'' is an important industrial site with numerous petrochemical and chemical industries; ''Ghent harbour'' has mainly metallurgic industries; the ''rural area'' is spread out over 9 contiguous areas in the western half of Flanders and with a low population density (o250 inhabitants/ km 2 ), no motorways on its territory and no industries reported in the emission inventory of the Flemish Environmental Protection Agency; ''waste incinerators'' comprised of neighbourhoods close to waste incinerators, spread out over the whole of Flanders (6 km-or 12 km in north-east direction-from the incinerator and with an immision, calculated with the Immission Frequency Distribution Model (IFDM), 41,20 mg smoke per m 3 ); the ''fruit area'' is a rural region with intensive apple or pear cultivation: 410 hectares per km 2 ; ''Olen'' is an industrial zone with a large nonferrous smelter, chemical and automobile industries amidst rural areas; and ''Albert Canal'' is an industrial zone with chemical industries and production facilities for electricity amidst rural areas.…”

Section: Selection Of Study Areasmentioning

confidence: 99%

“…In the ''Albert Canal'' area, participants residing maximum 6 km 2 from one of the six selected industrial companies, located along the canal, were selected (IFDM model). More detailed characteristics and emission data for the areas have been described by De Coster et al (2008).…”

Section: Selection Of Study Areasmentioning

confidence: 99%

Hormone levels and sexual development in Flemish adolescents residing in areas differing in pollution pressure

Croes

Baeyens

Bruckers

et al. 2009

International Journal of Hygiene and Environmental Health

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In 2002, the Centre for Environment and Health in Flanders, Belgium started a human biomonitoring program. For 1679 adolescents, residing in nine study areas with differing pollution pressure, hormone levels and the degree of sexual maturation were measured. Possible confounding effects of lifestyle and personal characteristics were taken into account. Participants from the nine different study areas had significantly different levels of sex hormones (total and free testosterone, oestradiol, aromatase, luteinizing hormone) and the thyroid hormone free triiodothyronine, after correction for confounders. Significantly higher hormone concentrations were measured in samples from participants residing in the area around the waste incinerators, while significantly lower values were found in participants residing in the Albert Canal zone with chemical industry. Sexual maturation of boys as well as girls tended to be somewhat slower in the industrial city of Antwerp and in the Antwerp harbour compared to the other areas in Flanders. Even within the same study area, significant differences in hormone levels could be observed between sub-areas. Data on the internal exposure of the same adolescents to lead, cadmium, PCBs, p,p 0 -DDE, HCB, 1-hydroxypyrene and t,t 0 -muconic acid have already been published. The observed differences in hormone levels and in sexual maturation could however only in part be explained by the measured differences in internal exposure to pollutants, suggesting that also other pollutants and other factors that vary in function of the area of residence could play a role. Nevertheless, our results also suggest that local (environmental) factors, acting within a short distance, might influence the measured hormone levels and degree of sexual maturation.

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“…Some studies suggest a relationship between Cd and PSA. The results of a study by de Coster et al (6) showed a significant correlation between urinary Cd levels of ≥p90 (1.24 µg/L) and PSA levels in the population group aged 50-65 years living in nine areas with different levels of air pollution.On the contrary, the results of a study by Pizent et al (7) found no significant association between blood Cd and PSA in men with a history of work unexposed to Cd. This indicates that a relationship will be found between Cd and PSA at high Cd levels but not at low Cd levels.…”

Section: Original Article Introductionmentioning

confidence: 94%

Blood cadmium levels increase prostate specific antigen and insulin-like growth factor-1 among cadmium exposed workers

Roestijawati¹,

Maurits²,

Sugiyanto³

2017

UnivMed

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BACKGROUND Cadmium (Cd) is a heavy metal that is classified as a human carcinogen (group IA), one of the cancers that it can cause being prostate cancer. The development of prostate cancer on a molecular basis involves oncogenes such as insuline-like growth factor-1 (IGF-1). Prostate cancer can be detected in the laboratory through the examination of prostate specific antigen (PSA). The present study aimed to determine the relationship of Cd levels with levels of PSA and IGF-1 in exposed and unexposed workers.METHODS The study design was cross sectional. The subjects of the studycame from two groups of workers, ie. the group of Cd exposed workers who were welding shop workers and the group of unexposed workers who were office workers. The minimum samplesize was 85 people. The independent variable was blood Cd level. The dependent variables were PSA and IGF-1 levels. Blood Cd levels were measured by atomic absorption spectrometry (AAS), while PSA and IGF-1 were measured using ELISA. Data analysis was performed using the Mann-Whitney test and the Spearman correlation test.RESULTS Mean blood Cd level in the exposed workers was 6.5 mg/L and in the unexposed workers 2.15 mg/L. There was a relationship between blood Cd and PSA levels (p<0.05) and between blood Cd levels and IGF-1 (p <0.05).CONCLUSIONS There was a relationship of blood Cd with PSA and IGF-1 levels.among workers. PSA and IGF-1 could be a biochemical markers of disease control in cadmium exposed workers.

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Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study

Abstract: Background: This study intended to investigate whether residence in areas polluted by heavy industry, waste incineration, a high density of traffic and housing or intensive use of pesticides, could contribute to the high incidence of cancer observed in Flanders.

Cited by 47 publications

References 78 publications

Internal exposure to pollutants and body size in Flemish adolescents and adults: Associations and dose–response relationships

Internal exposure to pollutants and body size in Flemish adolescents and adults: Associations and dose–response relationships

Hormone levels and sexual development in Flemish adolescents residing in areas differing in pollution pressure

Blood cadmium levels increase prostate specific antigen and insulin-like growth factor-1 among cadmium exposed workers

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