Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies

Abstract

An improved wound dressing with a long-term drug diffusion-efficacy has been developed by UV-radiation technique. It involves incorporation of ciprofloxacin (CIP), at the concentration of 0.5-2.0% (w/v), into a water mixture of 2-hydroxymethacrylate (HEMA) monomer, benzoin isobutyl ether (BIE) initiator and different content of ethylene glycol dimethacrylate (EGDMA) cross-linker. Increasing the concentration of EGDMA would reduce the releasing ratio of CIP from pHEMA. T1/2 is increased from 2.64 to 45.67 h when the EGDMA is added from 1 to 8%. In the ranges of 0< or = F < or = 0.6, the n value of 1%CIP-pHEMA membranes is increased from 0.48 to 0.81. It indicates that the mechanism of drug release falls between the Fickian and Case II diffusion model. The antibacterial activity of the drug impregnated into the membrane was evaluated by in vitro drug kinetic agar plate method. Higher concentration of EGDMA, up to 8% of the cross-linker, extends the drug release. Comparison with the drug-soaked membranes, the newly synthesized 1% CIP-pHEMA membrane (cross-linked with 4% EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days.

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

“…[1][2][3][23][24][25] The degree of swelling is 203%, 231% and 416% after 1 h, 4 h, and 24 h submersion of the blend nanofibrous mats, respectively.…”

“…Consequently, wounds often require treatment with antibiotics. [2][3][4][5] Local delivery of drugs sustained for about 1 week is preferred to systemic administration, especially for chronic wounds, 5 because of the advantages of these delivery systems such as: a) improving the effectiveness of drug therapy, and selective targeting, b) decreasing the side effects on a tissue, and interference with wound healing, c) reduction of bacterial resistance, and d) reducing the frequency of dressing replacements to increase patient compliance. 4,5 Furthermore, a proper wound dressing needs to have wound healing properties, including the essential swelling capability for absorbing excess exudates and oxygen permeability for respiring.…”

“…39 Ciprofloxacin, a fluoroquinolone antibiotic, is one of the most widely used antibiotics in wound healing because of its low minimal inhibitory concentration for both Gram-positive Staphylococcus and Gram-negative Pseudomonas bacteria that cause wound infections. 2,3 In the present research, an economical and convenient method of blending was applied to achieve a simultaneous controlled release of CipHCl and high swelling capacity along with coverage conformability for wound healing administration. PVAc, as an inexpensive and hydrophobic polymer, was selected to be blended with PVA solution.…”

Synthesis of ciprofloxacin-conjugated poly (L-lactic acid) polymer for nanofiber fabrication and antibacterial evaluation

“…Modulation of protease activity may therefore be significant in accelerating wound healing. 17 The study was performed by incubation of nanomat in buffer solution of pH 1, 5.9, 7.0, and 7.4. The in vitro release profile of nanomat is shown in Figure 11.…”

“…A few reports are available where ciprofloxacin is incorporated in different polymer matrices and release studies have been carried out. 17,18 No studies so far have addressed the possibility for the topical application of ciprofloxacin conjugated with biocompatible and biodegradable PLA (antibacterial nonwoven electrospun mat), particularly as a wound dressing material (bandage).…”