Poly(2-hydroxyethyl methacrylate)/β-cyclodextrin-hyaluronan contact lens with tear protein adsorption resistance and sustained drug delivery for ophthalmic diseases

Li, Ruicong; Guan, Xipeng; Lin, Xilin; Guan, Pengyue; Zhang, Xiong; Rao, Zhouquan; Du, Lin; Zhao, Jiafeng; Rong, Jian; Zhao, Jianhao

doi:10.1016/j.actbio.2020.04.002

Cited by 68 publications

(26 citation statements)

References 66 publications

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“…Recent research on ocular formulations containing CDs include: sustained-delivery eye drops [ 90 , 91 ]; in situ gelling systems [ 92 , 93 ]; mucoadhesive hydrogels [ 94 , 95 ]; CD/drug-loaded contact lenses [ 96 , 97 ]; and micro and nanosystems [ 86 , 98 , 99 ]. Also, CD-based formulations have shown potential to treat eye posterior segment diseases, such as diabetic retinopathy and age-related macular degeneration, which are commonly treated by intravitreal drug injections [ 100 ].…”

Section: Resultsmentioning

confidence: 99%

Technological evolution of cyclodextrins in the pharmaceutical field

Rincón-López

Almanza-Arjona

Riascos

et al. 2021

Journal of Drug Delivery Science and Technology

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We herein disclose how global cyclodextrin-based pharmaceutical technologies have evolved since the early 80s through a 1998 patents dataset retrieved from Derwent Innovation Index. We used text-mining techniques based on the patents semantic content to extract the knowledge contained therein, to analyze technologies related to the principal attributes of CDs: solubility, stability, and taste-masking enhancement. The majority of CDs pharmaceutical technologies are directed toward parenteral aqueous solutions. The development of oral and ocular formulations is rapidly growing, while technologies for nasal and pulmonary routes are emerging and seem to be promising. Formulations for topical, transdermal, vaginal, and rectal routes do not account for a high number of patents, but they may be hiding a great potential, representing opportunity research areas. Certainly, the progress in materials sciences, supramolecular chemistry, and nanotechnology, will influence the trend of that, apparently neglected, research. The bottom line, CDs pharmaceutical technologies are still increasing, and this trend is expected to continue in the coming years. Patent monitoring allows the identification of relevant technologies and trends to prioritize research, development, and investment in both, academia and industry. We expect the scope of this approach to be applied in the pharmaceutical field beyond CDs technological applications.

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Section: Resultsmentioning

confidence: 99%

Technological evolution of cyclodextrins in the pharmaceutical field

Rincón-López

Almanza-Arjona

Riascos

et al. 2021

Journal of Drug Delivery Science and Technology

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“…However, limited drug-loading and burst release are prevalent problems, with complete drug release from the lens within a few hours. Recently, some innovative strategies, such as in situ creation of a vitamin E barrier [ 9 ], molecular imprinting technology [ 10 ], drug-laden nanoparticles, the introduction of ionic or ‘host-guest’ interactions [ 11 ] and the incorporation of drug-loaded polymer films [ 12 ] have been reported to achieve the continuous release of drugs [ 13 , 14 , 15 , 16 , 17 , 18 ]. Although great efforts have been achieved in drug-eluting contact lenses, however, the critical lens properties, such as optical transparency, ion and oxygen permeability, mechanical durability, serialization and storage stability, as well as patient and practitioner acceptance have yet to be addressed [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Wang

Zhang

et al. 2021

Nanomaterials

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Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability have been developed to circumvent tedious eye drop instillation. In this work, zwitterionic nanogels based on poly(sulfobetaine methacrylate) (PSBMA) were easily fabricated by one-step reflux-precipitation polymerization, with the advantages of being surfactant-free and morphology controlled. Then, the ophthalmic drug levofloxacin (LEV) was encapsulated into the nanogels. A set of contact lenses with varied nanogel-loading content was fabricated by the cast molding method, with the drug-loaded nanogels dispersed in pre-monomer solutions composed of 2-hydroxyethyl methacrylate (HEMA) and N-vinyl-2-pyrrolidone (NVP). The structure, surface morphology, water contact angle (WCA), equilibrium water content (EWC), transmittance, and mechanical properties of the contact lenses were subsequently investigated, and in vitro drug release and biocompatibility were further evaluated. As a result, the optimized contact lens with nanogel-loading content of 8 wt% could sustainably deliver LEV for ten days, with critical lens properties within the range of recommended values for commercial contact lenses. Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment.

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“…By forming CD/NSAID and CD/antibiotic ICs, soluble and stable formulations were obtained [ 47 ]. Fascinating research in the field indeed announces that this upward trend will continue [ 48 , 49 , 50 , 51 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

When Cyclodextrins Met Data Science: Unveiling Their Pharmaceutical Applications through Network Science and Text-Mining

et al. 2021

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We present a data-driven approach to unveil the pharmaceutical technologies of cyclodextrins (CDs) by analyzing a dataset of CD pharmaceutical patents. First, we implemented network science techniques to represent CD patents as a single structure and provide a framework for unsupervised detection of keywords in the patent dataset. Guided by those keywords, we further mined the dataset to examine the patenting trends according to CD-based dosage forms. CD patents formed complex networks, evidencing the supremacy of CDs for solubility enhancement and how this has triggered cutting-edge applications based on or beyond the solubility improvement. The networks exposed the significance of CDs to formulate aqueous solutions, tablets, and powders. Additionally, they highlighted the role of CDs in formulations of anti-inflammatory drugs, cancer therapies, and antiviral strategies. Text-mining showed that the trends in CDs for aqueous solutions, tablets, and powders are going upward. Gels seem to be promising, while patches and fibers are emerging. Cyclodextrins’ potential in suspensions and emulsions is yet to be recognized and can become an opportunity area. This is the first unsupervised/supervised data-mining approach aimed at depicting a landscape of CDs to identify trending and emerging technologies and uncover opportunity areas in CD pharmaceutical research.

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Poly(2-hydroxyethyl methacrylate)/β-cyclodextrin-hyaluronan contact lens with tear protein adsorption resistance and sustained drug delivery for ophthalmic diseases

Cited by 68 publications

References 66 publications

Technological evolution of cyclodextrins in the pharmaceutical field

Technological evolution of cyclodextrins in the pharmaceutical field

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

When Cyclodextrins Met Data Science: Unveiling Their Pharmaceutical Applications through Network Science and Text-Mining

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