Poly(acrylic acid) microspheres loaded with superparamagnetic iron oxide nanoparticles for transcatheter arterial embolization and MRI detectability: In vitro and in vivo evaluation

Li, Zi-Yuan; Qin, X Y; Guo, Li-Ying; Wang, Huan; Liu, Xiaoxin; Zheng, Zhuozhao; Guan, Heng; Song, Li; Zou, Yinghua; Fan, Tian-Yuan

doi:10.1016/j.ijpharm.2017.04.069

Cited by 15 publications

(10 citation statements)

References 63 publications

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“…An identical conclusion was reported by Li et al . 30 , in which poly (acrylic acid) microspheres were loaded with superparamagnetic iron oxide nanoparticles, and their results verified that the presence of iron oxide nanoparticles does not influence the particle distribution of poly (acrylic acid) microspheres.…”

Section: Resultsmentioning

confidence: 61%

Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent

Hsu

Tyan

Chien

et al. 2018

Sci Rep

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The purpose of this study was to develop a gellan gum-based multifunctional embolic agent. Calibrated spherical gellan gum and nanoparticle-containing gellan gum microspheres were prepared via water-in oil emulsification method. Self-assembled nanoparticles composed of short-chain hyaluronic acid and polyethylenimine as the doxorubicin carrier were prepared. The short-chain hyaluronic acid/polyethylenimine/ doxorubicin (sHH/PH/Dox) with the mean size was 140 ± 8 nm. To examine sHH/PH/Dox nanoparticle uptake into cells, the results confirmed that sHH/PH nanoparticles as drug carrier can facilitate the transport of doxorubicin into HepG2 liver cancer cells. Subsequently, sHH/PH/Dox merged into the gellan gum (GG) microspheres forming GG/sHH/PH/Dox microsphere. After a drug release experiment lasting 45 days, the amount of released doxorubicin from 285, 388, and 481 μm GG/sHH/PH/Dox microspheres were approximately 4.8, 1.8 and 1.1-fold above the IC50 value of the HepG2 cell. GG/sHH/PH/Dox microspheres were performed in rabbit ear embolization model and ischemic necrosis on ear was visible due to the vascular after 8 days. Regarding the application of this device in the future, we aim to provide better embolization agents for transcatheter arterial chemoembolization (TACE).

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Section: Resultsmentioning

confidence: 61%

Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent

Hsu

Tyan

Chien

et al. 2018

Sci Rep

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“…FNMs in subgroup of 100–300 μm were selected and autoclaved at 121°C for 30 mins. The sterilized FNMs were suspended in sodium carboxylmethyl cellulose solution (1%, w/v) at a volume radio of 1:7, and 0.2 mL of the suspension was injected subcutaneously into the back of each mouse 17,34…”

Section: Methodsmentioning

confidence: 99%

“…Under the guidance of DSA (Innova®4100, GE Healthcare Technologies, USA), a 2.8 Fr catheter (Progreat®, Terumo Co., Tokyo, Japan) was inserted into the left renal artery by a guidewire, and Iodixanol was infused through the catheter to show the renal vessels. Then, 0.3 mL of FNMs suspended in a mixed solution of Iodixanol (0.3 mL) and saline (0.2 mL) was delivered slowly to the renal trunk 17. Arteriograms were performed before and after embolization to confirm the blood flow of kidney.…”

Section: Methodsmentioning

confidence: 99%

“…To evaluate the detectability of FNMs by MRI, the rabbits were scanned before and after embolization by a clinical 3.0 T MRI device (GE Medical Systems, LLC, USA) with a knee array coil. The scans were performed with the following two sequences, respectively: T 2 -weighted fast spin echo sequence (FSE; OA × T 2 PROPELLER: TR = 3478 ms, TE = 57 ms, FOV = 20 × 20 cm, flip angle = 180°, slice thickness = 4.0 mm and matrix = 256 × 256) and T 2 *-weighted gradient recalled echo sequence (GRE; OA × 2D MERGR: TR = 551 ms, TE = 5.2 ms, FOV = 20 × 20 cm, flip angle = 20°, slice thickness = 4.0 mm, and matrix = 256 × 224) 17. We also introduced △SNR to qualify the efficacy of contrast enhancement.…”

Section: Methodsmentioning

confidence: 99%

“…By using MRI-visualized microspheres, their position and compactness in blood vessel can be monitored by MRI and the embolic endpoints can be accurately judged, which is considered very important in chemoembolization, especially in the treatment of highly vascularized tumors. In addition, the distribution of embolization agents can offer feedback for radiologists to adjust intervention technology in time and provide individualized embolization, which would improve the overall therapeutic effects and lower the risk of operations 15–17…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<p>MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation</p>

Qin¹,

Liu²,

Li³

et al. 2019

IJN

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ObjectiveThe objective of this study was to develop magnetic embolic microspheres that could be visualized by clinical magnetic resonance imaging (MRI) scanners aiming to improve the efficiency and safety of embolotherapy.Methods and discussionMagnetic ferrite nanoclusters (FNs) were synthesized with microwave-assisted solvothermal method, and their morphology, particle size, crystalline structure, magnetic properties as well as T2 relaxivity were characterized to confirm the feasibility of FNs as an MRI probe. Magnetic polymer microspheres (FNMs) were then produced by inverse suspension polymerization with FNs embedded inside. The physicochemical and mechanical properties (including morphology, particle size, infrared spectra, elasticity, etc.) of FNMs were investigated, and the magnetic properties and MRI detectable properties of FNMs were also assayed by vibrating sample magnetometer and MRI scanners. Favorable biocompatibility and long-term MRI detectability of FNMs were then studied in mice by subcutaneous injection. FNMs were further used to embolize rabbits’ kidneys to evaluate the embolic property and detectability by MRI.ConclusionFNMs could serve as a promising MRI-visualized embolic material for embolotherapy in the future.

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Advances in Biomaterials and Technologies for Vascular Embolization

et al. 2019

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Minimally invasive transcatheter embolization is a common nonsurgical procedure in interventional radiology used for the deliberate occlusion of blood vessels for the treatment of diseased or injured vasculature. A wide variety of embolic agents including metallic coils, calibrated microspheres, and liquids are available for clinical practice. Additionally, advances in biomaterials, such as shapememory foams, biodegradable polymers, and in situ gelling solutions have led to the development of novel pre-clinical embolic agents. The aim here is to provide a comprehensive overview of current and emerging technologies in endovascular embolization with respect to devices, materials, mechanisms, and design guidelines. Limitations and challenges in embolic materials are also discussed to promote advancement in the field.

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Poly(acrylic acid) microspheres loaded with superparamagnetic iron oxide nanoparticles for transcatheter arterial embolization and MRI detectability: In vitro and in vivo evaluation

Cited by 15 publications

References 63 publications

Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent

Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent

<p>MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation</p>

Advances in Biomaterials and Technologies for Vascular Embolization

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