Poly(ADP-Ribose) in Nucleoids

Inducible processes in human cells by low doses of genotoxic physical and chemical factors

“…Poly(ADP-ribosyl)ation seems to be a general chromatin function serving to maintain, restore or alter the normal chromatin structure, possibly in the organization of the DNA/nuclear matrix complex [52,53,54]. The induction of the PAR-P enzyme from de novo synthesis occurs after mitogen or antibody stimulation and after DNA damage [55,56].…”