Poly (amido amine) dendrimer/silver nanoparticles/multi-walled carbon nanotubes/poly (neutral red)-modified electrode for electrochemical determination of paracetamol

Chakkarapani, Lakshmi Devi; Narayanan, S. Sriman

doi:10.1007/s11581-018-2609-0

Cited by 25 publications

(7 citation statements)

References 57 publications

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“…In contrast, electrochemistry with voltammetric platforms can provide sensitive and selective determination of drugs in pharmaceutical preparations and biological fluids without the requirement of extraction step [3]. Voltammetric platforms based on poly(EDOT)-poly(styren)-N-doped graphene/carbon nitride [4], Zn/Ni-ZIF and the electropolymerization of caffeic acid [5], poly(amidoamine)-Ag-CNTs/poly (neutral red) [6], polyimide-MWCNT [7], AuNPs/MWCNTs with thiolated calix [8]arene [8], poly(amido amine)-poly(Nile blue) [9], carbon blackpoly(acrylic acid)-La 2 O 3 [10], poly (rhodamine B) [11], Pd-graphene oxide [12], DNA [13], poly luminol-carbon nanotubes [14] were applied for the detection of paracetamol. Shi et.…”

Section: Introductionmentioning

confidence: 99%

A facile and sensitive method of analysis for the determination of paracetamol on a boron doped diamond electrode modified with carbon based nanomaterials

Kutluay Baytak,

Gezen,

Aslanoglu

2024

Electroanalysis

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This study presents the development of a facile and sensitive method of analysis for the determination of paracetamol. For this purpose, a boron doped diamond electrode (BDDE) was modified with a composite of carbon nanotubes (CNT), carbon nanofibers (CNF) and carbon black nanoballs (CNB). The voltammetric properties of paracetamol were studied, compared and discussed on unmodified BDDE, CNB/BDDE, CNF/BDDE, CNT/BDDE, CNB@CNF/BDDE, CNF@CNT/BDDE and CNF@CNB@CNT/BDDE. An increase in peak response (Ip) and a dramatic decrease in peak separation (ΔEp) were observed at electrodes in an order from bare BDDE to CNB/BDDE, CNF/BDDE, CNT/BDDE, CNB@CNF/BDDE, CNF@CNT/BDDE and CNF@CNB@CNT/BDDE. This clearly showed that the composite material of CNF@CNB@CNT provided an excellent surface on BDDE leading to a fast electrode reaction of paracetamol. Interestlingly, the amount composite layer on the voltammetry of paracetamol also caused a remarkable decrease in ΔEp and resulted in high electrocatalytic activity. The detection of paracetamol based on the BDDE modified with a composite of CNF@CNB@CNT exhibited stability, excellent selectivity and good sensitivity, with a low detection limit of 0.47±0.002 nM (based on 3sb/m) and wide linear range of 1.5 nM–200 nM. These results demonstrate that CNF@CNB@CNT/BDDE can serve as an ideal voltammetric platform for constructing a paracetamol sensor. The proposed electrochemical platform (CNF@CNB@CNT/BDDE) was also successfully applied for the determination of paracetamol in pharmaceuticals and body fluids.

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Section: Introductionmentioning

confidence: 99%

A facile and sensitive method of analysis for the determination of paracetamol on a boron doped diamond electrode modified with carbon based nanomaterials

Kutluay Baytak,

Gezen,

Aslanoglu

2024

Electroanalysis

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“…Methylene blue and Neutral red in polymeric form have been described in the assembly of the electrochemical sensors for the determination of many small organic molecules interesting for medicine, pharmacy, and environmental monitoring, e.g., catechin [18], nevirapine [19], paracetamol [20], vanillomandelic and homovanillic acids [21], catechol and hydroquinone [22], and ascorbic acid [23]. Methylene blue has found a broad application as a redox probe and diffusionally-free indicator in DNAand aptasensors [24,25].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical DNA Sensor Based on the Copolymer of Proflavine and Azure B for Doxorubicin Determination

Porfireva

Evtugyn

2020

Nanomaterials

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A DNA sensor has been developed for the determination of doxorubicin by consecutive electropolymerization of an equimolar mixture of Azure B and proflavine and adsorption of native DNA from salmon sperm on a polymer film. Electrochemical investigation showed a difference in the behavior of individual drugs polymerized and their mixture. The use of the copolymer offered some advantages, i.e., a higher roughness of the surface, a wider range of the pH sensitivity of the response, a denser and more robust film, etc. The formation of the polymer film and its redox properties were studied using scanning electron microscopy and electrochemical impedance spectroscopy. For the doxorubicin determination, its solution was mixed with DNA and applied on the polymer surface. After that, charge transfer resistance was assessed in the presence of [Fe(CN)6]3−/4− as the redox probe. Its value regularly grew with the doxorubicin concentration in the range from 0.03 to 10 nM (limit of detection 0.01 nM). The DNA sensor was tested on the doxorubicin preparations and spiked samples mimicking blood serum. The recovery was found to be 98–106%. The DNA sensor developed can find application for the determination of drug residues in blood and for the pharmacokinetics studies.

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“…Compared with the traditional analytical methods, electrochemical sensors development for bioamine detection have gained increasing attention because of their selectivity, sensitivity, low cast, user friendly instruments handling, on spot sample analysis and short analysis time [15]. Recently various electro active materials are used for electrochemical sensors development such as conducting polymers, nano materials, nano particles, nanotubes, metal complexes, and graphene etc., [16][17][18]. Among all, conducting polymers, modified electrochemical sensor has become a hot topic and opens a new domain in the area of analytical science.…”

Section: Introductionmentioning

confidence: 99%

Carbon Screen-Printed Electrode Coated with Poly (Toluidine blue) as an Electrochemical Sensor for the Detection of Tyramine

Chakkarapani

Brandl

2020

7th International Electronic Conference on Sensors and Applications

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In the present work the surface modification of a carbon screen-printed electrode by electrochemical polymerization of toluidine blue (TB) for determination of tyramine is described. The electrochemical polymerization of the electrode with TB was done by cyclic voltammetry at a scan rate of 50 mV/s and a potential sweep between ‒0.7 V and 1.0 V in the presence of 0.5 mM TB in an electrolyte solution. At each cycle, the polymer film started to deposit on the carbon screen-printed electrode which was repeated 20 times. For parameter optimization the electrochemical behavior of the modified electrode was analyzed by amperometric methods such as cyclic voltammetry (CV) and differential pulse voltammetry (DPV). A phosphate buffer solution (PBS) was used as an electrolyte for all the amperometric experiments. The electrochemically modified poly-TB-coated carbon-screen-printed electrode showed an oxidation peak potential of tyramine at 0.67 V. The unmodified carbon-screen-printed electrode showed the tyramine oxidation peak potential at 0.9 V. Based on the voltammetric results, it was found that the poly-TB-modified carbon-screen-printed electrode showed higher sensitivity (1.78 µA nM−1 cm−2) than a bare carbon-screen-printed electrode toward tyramine detection. Tyramine in 0.1 M PBS (pH 7.4) was analyzed by cyclic voltammetry from the potential of ‒0.7 to 1.0 V at a scan rate of 50 mV/s. The poly-TB-modified carbon-screen-printed electrode exhibited a linear response between catalytic peak current and tyramine concentration from 0.02 µM to 270.5 µM with a lower detection limit of 0.007 µM (S/N = 3).

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Poly (amido amine) dendrimer/silver nanoparticles/multi-walled carbon nanotubes/poly (neutral red)-modified electrode for electrochemical determination of paracetamol

Cited by 25 publications

References 57 publications

A facile and sensitive method of analysis for the determination of paracetamol on a boron doped diamond electrode modified with carbon based nanomaterials

A facile and sensitive method of analysis for the determination of paracetamol on a boron doped diamond electrode modified with carbon based nanomaterials

Electrochemical DNA Sensor Based on the Copolymer of Proflavine and Azure B for Doxorubicin Determination

Carbon Screen-Printed Electrode Coated with Poly (Toluidine blue) as an Electrochemical Sensor for the Detection of Tyramine

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